Hostname: page-component-7479d7b7d-wxhwt Total loading time: 0 Render date: 2024-07-08T07:49:22.096Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationship of sperm motility with clinical outcome of percutaneous epididymal sperm aspiration–intracytoplasmic sperm injection in infertile males with congenital domestic absence of vas deferens: a retrospective study

Published online by Cambridge University Press:  27 July 2021

Zhong Jixiang Open the ORCID record for Zhong Jixiang [Opens in a new window] ,
Zhang Lianmei ,
Zuo Yanghua  and
Xue Huiying
Zhong Jixiang*
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
Zhang Lianmei
Affiliation:
Department of Pathology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, China
Zuo Yanghua
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
Xue Huiying
Affiliation:
Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China
*
Author for correspondence: Zhong Jixiang, Department of Infertility, Jiangsu Huaian Maternity and Children Hospital, Huaian, China. E-mail: zhongjixiang2006@163.com
Get access Rights & Permissions [Opens in a new window]

Summary

Congenital domestic absence of vas deferens (CBAVD) is a common factor in male infertility, and percutaneous epididymal sperm aspiration (PESA) combined with intracytoplasmic sperm injection (ICSI) is a primary clinical treatment, but the effect of the sperm obtained on pregnancy outcome remains to be explored. This study aimed to investigate the relationship between sperm motility with clinical outcome of PESA–ICSI in infertile males with CBAVD. A cohort of 110 couples was enrolled. In total, 76 infertile males were included in the high motility group, while the remaining 34 males were placed in the low motility group. Clinical pregnancy, embryo implantation rate and live birth rate were included as the primary outcome. After all follow-ups, we found that the high motility group achieved higher normal fertilization rates, cleavage rates, transplantable embryo rates and high-quality embryo rates than those in low motility group (normal fertilization rate, 78.2 ± 11.7% vs. 70.5 ± 10.2%, P = 0.003; cleavage rate, 97.1 ± 2.9% vs. 92.3 ± 3.0%, P = 0.000; transplantable embryo rate, 66.8 ± 14.9% vs. 58.6 ± 12.6%, P = 0.009 and high-quality embryo rate, 49.9 ± 10.5% vs. 40.5 ± 11.2%, P = 0.000). Additionally, compared with the low motility group, the clinical pregnancy rates, embryo implantation rates, and live birth rates in the high motility group were significantly increased (pregnancy rate, 61.8% vs. 26.5%, P = 0.009; embryo implantation rate, 36.5% vs. 18.0%, P = 0.044; live birth rate, 55.3% vs. 17.6%, P = 0.000). We concluded that the motility of sperm obtained by PESA affected the clinical outcome of ICSI in infertile males with CBAVD.

Keywords

Congenital bilateral absence of vas deferensIntracytoplasmic sperm injectionLive birth ratePercutaneous epididymal sperm aspirationSperm motility
Type
Research Article
Information
Zygote , Volume 30 , Issue 2 , April 2022 , pp. 234 - 238
Copyright
© The Author(s), 2021. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abdul-Jalil, AK, Child, TJ, Phillips, S, Dean, N, Carrier, S and Tan, SL (2001). Ongoing twin pregnancy after ICSI of PESA-retrieved spermatozoa into in-vitro matured oocytes: Case report. Hum Reprod 16, 1424–6.Google ScholarPubMed
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology (2011). The Istanbul consensus workshop on embryo assessment: Proceedings of an expert meeting. Hum Reprod 26, 1270–83.CrossRefGoogle Scholar
Buch, JP (1994). Live birth resulting from in-office vas deferens sperm retrieval combined with natural-cycle insemination. Hum Reprod 9, 875–7.Google ScholarPubMed
Chi, HJ, Kim, SG, Kim, YY, Park, JY, Yoo, CS, Park, IH, Sun, HG, Kim, JW, Lee, KH and Park, HD (2017). ICSI significantly improved the pregnancy rate of patients with a high sperm DNA fragmentation index. Clin Exp Reprod Med 44, 132–40.Google ScholarPubMed
Dar, S, Grover, SA, Moskovtsev, SI, Swanson, S, Baratz, A and Librach, CL (2013). In vitro fertilization-intracytoplasmic sperm injection outcome in patients with a markedly high DNA fragmentation index (>50%). Fertil Steril 100, 75–80.Google Scholar
Desai, N and Goldfarb, J (2007). ICSI with cryopreserved epididymal and testicular sperm can yield high clinical pregnancy and implantation rates strategies to improve success. Fertil Steril 88, S342–3.Google Scholar
Donnelly, ET, McClure, N and Lewis, SE (2000). Glutathione and hypotaurine in vitro: Effects on human sperm motility, DNA integrity and production of reactive oxygen species. Mutagenesis 15, 61–8.Google ScholarPubMed
Emiliani, S, Van den Bergh, M, Vannin, AS, Biramane, J, Verdoodt, M and Englert, Y (2000). Increased sperm motility after in-vitro culture of testicular biopsies from obstructive azoospermic patients results in better post-thaw recovery rate. Hum Reprod 15, 2371–4.CrossRefGoogle ScholarPubMed
García-Roselló, E, Coy, P, García Vázquez, FA, Ruiz, S and Matás, C (2006). Analysis of different factors influencing the intracytoplasmic sperm injection (ICSI) yield in pigs. Theriogenology 66, 1857–65.Google ScholarPubMed
Gavriliouk, D and Aitken, RJ (2015). Damage to sperm DNA mediated by reactive oxygen species: Its impact on human reproduction and the health trajectory of offspring. Adv Exp Med Biol 868, 23–47.CrossRefGoogle ScholarPubMed
Giwercman, A, Richthoff, J, Hjøllund, H, Bonde, JP, Jepson, K, Frohm, B and Spano, M (2003). Correlation between sperm motility and sperm chromatin structure assay parameters. Fertil Steril 80, 1404–12.CrossRefGoogle ScholarPubMed
Gorgy, A, Podsiadly, BT, Bates, S and Craft, IL (1998). Testicular sperm aspiration (TESA): the appropriate technique. Hum Reprod 13, 1111–3.Google ScholarPubMed
Korosi, T, Barta, C, Rokob, K and Torok, T (2017). Physiological intra-cytoplasmic sperm injection (PICSI) outcomes after oral pretreatment and semen incubation with myo-inositol in oligoasthenoteratozoospermic men: results from a prospective, randomized controlled trial. Eur Rev Med Pharmacol Sci 21 Suppl, 66–72.Google ScholarPubMed
Leaver, RB (2016). Male infertility: an overview of causes and treatment options. Br J Nurs 25, S35–40.Google ScholarPubMed
Ng, CM, Blackman, MR, Wang, C and Swerdloff, RS (2004). The role of carnitine in the male reproductive system. Ann NY Acad Sci 1033, 177–88.Google ScholarPubMed
Olds-Clarke, P (1996). How does poor motility alter sperm fertilizing ability? J Androl 17, 183–6.Google ScholarPubMed
O’Neill, CL, Chow, S, Rosenwaks, Z and Palermo, GD (2018). Development of ICSI. Reproduction 156, F51–8.Google ScholarPubMed
Oum, KB, Sohn, JO, Kim, HJ, Lee, HK and Cha, KY (1997). Successful fertilization and pregnancy with non-motile sperm in ICSI program. Fertil Steril 1997, 105.Google Scholar
Pasqualotto, FF, Rossi-Ferragut, LM, Rocha, CC, Iaconelli, A and Borges, E (2002). Outcome of in vitro fertilization and intracytoplasmic injection of epididymal and testicular sperm obtained from patients with obstructive and nonobstructive azoospermia. J Urol 167, 1753–6.CrossRefGoogle ScholarPubMed
Plachot, M, Belaisch-Allart, J, Mayenga, JM, Chouraqui, A, Tesquier, L and Serkine, AM (2002). Outcome of conventional IVF and ICSI on sibling oocytes in mild male factor infertility. Hum Reprod 17, 362–9.Google ScholarPubMed
Sadeghi, MR, Lakpour, N, Heidari-Vala, H, Hodjat, M, Amirjannati, N, Hossaini Jadda, H, Binaafar, S and Akhondi, MM (2011). Relationship between sperm chromatin status and ICSI outcome in men with obstructive azoospermia and unexplained infertile normozoospermia. Roman J Morphol Embryol 52, 645–51.Google ScholarPubMed
Seo, JT and Ko, WJ (2001). Predictive factors of successful testicular sperm recovery in non-obstructive azoospermia patients. Int J Androl 24, 306–10.Google ScholarPubMed
Singh, RP, Shafeeque, CM, Sharma, SK, Pandey, NK, Singh, R, Mohan, J, Kolluri, G, Saxena, M, Sharma, B, Sastry, KV, Kataria, JM and Azeez, PA (2015). Bisphenol A reduces fertilizing ability and motility by compromising mitochondrial function of sperm. Environ Toxicol Chem 34, 1617–22.Google Scholar
Son, IP, Hong, JY, Lee, YS, Park, YS, Jun, JH, Lee, HJ, Kang, IS and Jun, JY (1996). Efficacy of microsurgical epididymal sperm aspiration (MESA) and intracytoplasmic sperm injection (ICSI) in obstructive azoospermia. J Assist Reprod Genet 13, 69–72.CrossRefGoogle Scholar
Tang, LF, Jiang, H, Shang, XJ, Zhao, LM, Bai, Q, Hong, K, Liu, DF, Liu, JM, Yuan, RP, Chen, Q and Ma, LL (2008). Seminal plasma levocarnitine significantly correlated with semen quality. Zhonghua Nan Ke Xue 14, 704–8.Google ScholarPubMed
Treulen, F, Uribe, P, Boguen, R and Villegas, JV (2015). Mitochondrial permeability transition increases reactive oxygen species production and induces DNA fragmentation in human spermatozoa. Hum Reprod 30, 767–76.CrossRefGoogle ScholarPubMed
Tsirigotis, M, Pelekanos, M, Beski, S, Gregorakis, S, Foster, C and Craft, IL (1996). Cumulative experience of percutaneous epididymal sperm aspiration (PESA) with intracytoplasmic sperm injection. J Assist Reprod Genet 13, 315–9.Google ScholarPubMed
Tunc, O and Tremellen, K (2009). Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet 26(9–10), 537–44.Google ScholarPubMed
Wang, E, Huang, Y, Du, Q and Sun, Y (2017). Silver nanoparticle induced toxicity to human sperm by increasing ROS (reactive oxygen species) production and DNA damage. Environ Toxicol Pharmacol 52, 193–9.CrossRefGoogle ScholarPubMed
Wood, S, Sephton, V, Searle, T, Thomas, K, Schnauffer, K, Troup, S, Kingsland, C and Lewis-Jones, I (2003). Effect on clinical outcome of the interval between collection of epididymal and testicular spermatozoa and intracytoplasmic sperm injection in obstructive azoospermia. J Androl 24, 67–72.Google ScholarPubMed
Wu, ZM, Lu, X, Wang, YW, Sun, J, Tao, JW, Yin, FH and Cheng, HJ (2012). Short-term medication of l-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia. Zhonghua Nan Ke Xue 18, 253–6.Google ScholarPubMed
Zhang, Z, Zhu, L, Jiang, H, Chen, H, Chen, Y and Dai, Y (2015). Sperm DNA fragmentation index and pregnancy outcome after IVF or ICSI: a meta-analysis. J Assist Reprod Genet 32, 17–26.CrossRefGoogle ScholarPubMed
Zhang, J, Xue, H, Qiu, F, Zhong, J and Su, J (2019). Testicular spermatozoon is superior to ejaculated spermatozoon for intracytoplasmic sperm injection to achieve pregnancy in infertile males with high sperm DNA damage. Andrologia 51, e13175.CrossRefGoogle ScholarPubMed