New weed management tools and growth regulators make production of ultra narrow row (UNR) cotton possible. Weed control, cotton yield, fiber quality, and net returns were compared in UNR bromoxynil-resistant, glyphosate-resistant, and nontransgenic cotton. Weeds included broadleaf signalgrass, carpetweed, common cocklebur, common lambsquarters, common ragweed, goosegrass, jimsonweed, large crabgrass, Palmer amaranth, pitted morningglory, prickly sida, sicklepod, smooth pigweed, and tall morningglory. Pendimethalin preplant incorporated (PPI) in conventional-tillage or preemergence (PRE) in no-till systems plus fluometuron PRE did not adequately control many of these weeds. Pyrithiobac plus MSMA early postemergence (POST) often was more effective than pyrithiobac alone. Pendimethalin plus fluometuron at planting followed by pyrithiobac plus MSMA early POST controlled sicklepod 82%, goosegrass 89%, Palmer amaranth 92%, and the other species at least 95% late season. Pyrithiobac at mid-POST did not improve control. Bromoxynil plus MSMA early POST was more effective than bromoxynil alone only on sicklepod. Pendimethalin plus fluometuron at planting followed by bromoxynil plus MSMA early POST controlled sicklepod 62%, Palmer amaranth 81%, goosegrass 83%, and all other species at least 95%. Glyphosate early POST did not adequately control many species due to sustained weed emergence. Glyphosate early POST followed by glyphosate late POST (after last effective bloom date) controlled all species except pitted morningglory and tall morningglory at least 93%. Pendimethalin plus fluometuron followed by glyphosate early POST was the most effective glyphosate system overall, and it controlled sicklepod 88%, pitted morningglory 90%, and other species at least 93%. Glyphosate late POST did not increase control in systems with pendimethalin plus fluometuron at planting followed by glyphosate early POST. Yields and net returns were similar with all herbicide/cultivar systems at two of five locations. At other locations, yields and net returns were similar with systems of pendimethalin plus fluometuron at planting followed by pyrithiobac plus MSMA early POST, pendimethalin plus fluometuron followed by bromoxynil plus MSMA early POST, and glyphosate early POST. Greatest yields and net returns were obtained with pendimethalin plus fluometuron at planting followed by glyphosate early POST. Herbicide systems did not affect fiber quality.