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Simulation analysis of receptive-field size of retinal horizontal cells by ionic current model

Published online by Cambridge University Press:  05 April 2005

TOSHIHIRO AOYAMA ,
YOSHIMI KAMIYAMA  and
SHIRO USUI
TOSHIHIRO AOYAMA
Affiliation:
Department of Electronic and Information Engineering, Suzuka National College of Technology, Shiroko, Suzuka-City, Japan
YOSHIMI KAMIYAMA
Affiliation:
Faculty of Information Science and Technology, Aichi Prefectural University, Nagakute, Japan
SHIRO USUI
Affiliation:
Brain Science Institute, RIKEN, Wako, Saitama, Japan
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Abstract

The size of the receptive field of retinal horizontal cells changes with the state of dark/light adaptation. We have used a mathematical model to determine how changes in the membrane conductance affect the receptive-field properties of horizontal cells. We first modeled the nonlinear membrane properties of horizontal cells based on ionic current mechanisms. The dissociated horizontal cell model reproduced the voltage–current (V–I) relationships for various extracellular glutamate concentrations measured in electrophysiological studies. Second, a network horizontal cell model was also described, and it reproduced the V–I relationship observed in vivo. The network model showed a bell-shaped relationship between the receptive-field size and constant glutamate concentration. The simulated results suggest that the calcium current is a candidate for the bell-shaped length constant relationship.

Keywords

Retinal horizontal cellReceptive fieldIonic currentMathematical model
Type
Research Article
Information
Visual Neuroscience , Volume 22 , Issue 1 , January 2005 , pp. 65 - 78
Copyright
© 2005 Cambridge University Press

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