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Residual abilities in age-related macular degeneration to process spatial frequencies during natural scene categorization

Published online by Cambridge University Press:  22 December 2011

BENOIT MUSEL ,
RUXANDRA HERA ,
SYLVIE CHOKRON ,
DAVID ALLEYSSON ,
CHRISTOPHE CHIQUET ,
JEAN-PAUL ROMANET ,
NATHALIE GUYADER  and
CAROLE PEYRIN
BENOIT MUSEL*
Affiliation:
Laboratoire de Psychologie et NeuroCognition, Centre National de la Recherche Scientifique UMR 5105, Université Pierre Mendès France, Grenoble, France
RUXANDRA HERA
Affiliation:
Service d’ophtalmologie, CHU Albert Michalon, Grenoble, France
SYLVIE CHOKRON
Affiliation:
Laboratoire de Psychologie et NeuroCognition, Centre National de la Recherche Scientifique UMR 5105, Université Pierre Mendès France, Grenoble, France Unité Fonctionnelle Vision et Cognition, Fondation Ophtalmologique Rothschild, Paris, France
DAVID ALLEYSSON
Affiliation:
Laboratoire de Psychologie et NeuroCognition, Centre National de la Recherche Scientifique UMR 5105, Université Pierre Mendès France, Grenoble, France
CHRISTOPHE CHIQUET
Affiliation:
Service d’ophtalmologie, CHU Albert Michalon, Grenoble, France
JEAN-PAUL ROMANET
Affiliation:
Service d’ophtalmologie, CHU Albert Michalon, Grenoble, France
NATHALIE GUYADER
Affiliation:
Grenoble-Image-Parole-Signal-Automatique (GIPSA-lab), CNRS UMR 5216, Grenoble, France
CAROLE PEYRIN
Affiliation:
Laboratoire de Psychologie et NeuroCognition, Centre National de la Recherche Scientifique UMR 5105, Université Pierre Mendès France, Grenoble, France
*
*Address correspondence and reprint requests to: Benoit Musel, Laboratoire de Psychologie et NeuroCognition, CNRS UMR 5105, Université Pierre Mendès France, BP 47 38040 Grenoble Cedex, France. E-mail: benoit.musel@upmf-grenoble.fr
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Abstract

Age-related macular degeneration (AMD) is characterized by a central vision loss. We explored the relationship between the retinal lesions in AMD patients and the processing of spatial frequencies in natural scene categorization. Since the lesion on the retina is central, we expected preservation of low spatial frequency (LSF) processing and the impairment of high spatial frequency (HSF) processing. We conducted two experiments that differed in the set of scene stimuli used and their exposure duration. Twelve AMD patients and 12 healthy age-matched participants in Experiment 1 and 10 different AMD patients and 10 healthy age-matched participants in Experiment 2 performed categorization tasks of natural scenes (Indoors vs. Outdoors) filtered in LSF and HSF. Experiment 1 revealed that AMD patients made more no-responses to categorize HSF than LSF scenes, irrespective of the scene category. In addition, AMD patients had longer reaction times to categorize HSF than LSF scenes only for indoors. Healthy participants’ performance was not differentially affected by spatial frequency content of the scenes. In Experiment 2, AMD patients demonstrated the same pattern of errors as in Experiment 1. Furthermore, AMD patients had longer reaction times to categorize HSF than LSF scenes, irrespective of the scene category. Again, spatial frequency processing was equivalent for healthy participants. The present findings point to a specific deficit in the processing of HSF information contained in photographs of natural scenes in AMD patients. The processing of LSF information is relatively preserved. Moreover, the fact that the deficit is more important when categorizing HSF indoors, may lead to new perspectives for rehabilitation procedures in AMD.

Keywords

Low visionIndoor/OutdoorLow spatial frequencyHigh spatial frequencyVisual categorization
Type
Research Articles
Information
Visual Neuroscience , Volume 28 , Issue 6 , November 2011 , pp. 529 - 541
Copyright
Copyright © Cambridge University Press 2011

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