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Nerve growth factor preserves behavioral visual acuity in monocularly deprived kittens

Published online by Cambridge University Press:  02 June 2009

A. Fiorentini ,
N. Berardi  and
L. Maffei
A. Fiorentini
Affiliation:
Istituto di Neurofisiologia C.N.R., Pisa, Italy
N. Berardi
Affiliation:
Istituto di Neurofisiologia C.N.R., Pisa, Italy Dipartimento di Fisiologia Generale e Ambientale, Universitá di Napoli, Italy
L. Maffei
Affiliation:
Istituto di Neurofisiologia C.N.R., Pisa, Italy Scuola Normale Superiore, Pisa, Italy
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Abstract

Recent electrophysiological and anatomical experiments in rats and cats have shown that treatment with the neurotrophic factor — nerve growth factor (NGF) — prevents the effects of monocular deprivation (MD) at the level of visual cortex and lateral geniculate nucleus. We tested whether NGF treatment was effective in preventing MD effects on visual behavior of monocularly deprived kittens. Behavioral visual acuity was measured in kittens that had been monocularly deprived and treated intraventricularly with NGF for 2 weeks during the critical postnatal period. The detrimental effects of MD on behavioral visual acuity were found to be largely prevented by NGF treatment.

Keywords

Nerve growth factorVisual deprivationBehavioral visual acuityCat
Type
Research Articles
Information
Visual Neuroscience , Volume 12 , Issue 1 , January 1995 , pp. 51 - 55
Copyright
Copyright © Cambridge University Press 1995

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References

Berardi, N., Domenici, L., Parisi, V., Pizzorusso, T., Cellerino, A. & Maffei, L. (1993). Monocular deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented by nerve growth factor (NGF). I. Visual cortex. Proceedings of the Royal Society B (London) 251, 17–23.Google ScholarPubMed
Berkley, M.A. (1976). Cat visual psychophysics: Neural correlates and comparison with man. Progress in Psychobiology and Physiological Psychology 6, 63–119.Google Scholar
Boothe, R.G., Dobson, M.V. & Teller, D.Y. (1985). Postnatal development of vision in human and non-human primates. Annual Review of Neuroscience 8, 495–545.CrossRefGoogle Scholar
Bozzi, Y., Pizzorusso, T., Cremisi, F., Comelli, M.C., Berardi, N. & Maffei, L. (1993). Monocular deprivation decreases the expression of BDNF mRNA in the rat visual cortex. Society for Neuroscience Abstracts 19, 8.7.Google Scholar
Carmignoto, G., Canella, R., Candeo, P. & Comelli, M.C. (1993). Effects of nerve growth factor on neuronal plasticity of the kitten visual cortex. Journal of Physiology (London) 464, 343–360.CrossRefGoogle ScholarPubMed
Castren, E., Zafra, F., Thoenen, H. & Lindholm, D. (1992). Light regulates the expression of BDNF mRNA in the rat visual cortex. Proceedings of the National Academy of Sciences of the U.S.A. 89, 9444–9448.CrossRefGoogle ScholarPubMed
Cornsweet, T.N. (1962). The staircase method in psychophysics. American Journal of Psychology 75, 485–491.CrossRefGoogle Scholar
Dews, P.B. & Wiesel, T.N. (1970). Consequences of monocular deprivation on visual behaviour in kittens. Journal of Physiology 206, 437–455.CrossRefGoogle ScholarPubMed
Domenici, L., Berardi, N., Carmignoto, G., Vantini, G. & Maffei, L. (1991). Nerve growth factor prevents the amblyopic effects of monocular deprivation. Proceedings of the National Academy of Sciences of the U.S.A. 88, 8811–8815.CrossRefGoogle ScholarPubMed
Domenici, L., Cellerino, A. & Maffei, L. (1993). Monocular deprivation effects in the rat visual cortex and lateral geniculate nucleus are prevented by nerve growth factor (NGF): LGN. Proceedings of the Royal Society B (London) 251, 25–31.Google Scholar
Friden, P.M., Walus, L.R., Watson, P., Kozarich, J.W., Backman, C., Bergman, H., Hoffer, B., Bloom, F. & Granholm, A.C. (1993). Blood-brain barrier penetration and in-vivo activity of an NGF conjugate. Science 259, 373–377.CrossRefGoogle ScholarPubMed
Giffin, F. & Mitchell, D.E. (1978). The rate of recovery of vision after early monocular deprivation in kittens. Journal of Physiology (London) 274, 511–537.CrossRefGoogle ScholarPubMed
Maffei, L., Berardi, N., Domenici, L., Parisi, V. & Pizzorusso, T. (1992). Nerve growth factor (NGF) prevents the shift in ocular-dominance distribution of visual cortical neurons in monocularly deprived rats. Journal of Neuroscience 12, 4651–4662.CrossRefGoogle ScholarPubMed
Mitchell, D.E., Cynader, M. & Movshon, J.A. (1977). Recovery of the effects of monocular deprivation in kittens. Journal of Comparative Neurology 176, 53–64.CrossRefGoogle ScholarPubMed
Mitchell, D.E., Giffin, F., Wilkinson, F., Anderson, P. & Smith, M.L. (1976). Visual resolution in young kittens. Vision Research 16, 363–366.CrossRefGoogle ScholarPubMed
Mitchell, D.E., Giffin, F. & Timney, B. (1977). A behavioural technique for the rapid assessment of the visual capabilities of kittens. Perception 6, 181–193.CrossRefGoogle ScholarPubMed
Pasternak, T. & Merigan, W.H. (1981). The luminance dependence of spatial vision in the cat. Vision Research 21, 1333–1339.CrossRefGoogle ScholarPubMed
Purves, D. & Lichtman, J.W. (1985). Principles of Neural Development. Sunderland, Massachusetts: Sinauer Associates.Google Scholar
Purves, D., Snider, W.D. & Voyvodic, J.T. (1984). Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system. Nature (London) 336, 123–128.CrossRefGoogle Scholar
Rothblat, L.A., Schwartz, L.M. & Kasdan, P.M. (1978). Monocular deprivation in the rat: Evidence for an age-related defect in visual behaviour. Brain Research 158, 456–460.CrossRefGoogle Scholar
Shatz, C.J. (1990). Impulse activity and the patterning of connections during CNS development. Neuron 5, 745–756.CrossRefGoogle ScholarPubMed
Shatz, C.J. & Stryker, M.P. (1978). Ocular dominance in layer IV of the cat visual cortex and the effects of visual deprivation. Journal of Physiology (London) 281, 267–283.CrossRefGoogle Scholar
Sireteanu, R. (1985). The development of visual acuity in very young kittens: A study with forced-choice preferential looking. Vision Research 25, 781–788.CrossRefGoogle ScholarPubMed
von Noorden, G.K. (1985). Amblyopia: A multidisciplinary approach. Investigative Ophthalmology and Visual Science 26, 1705–1716.Google ScholarPubMed