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Excitatory amino acid receptors modulate habituation of the response to visual stimulation in the cat superior colliculus

Published online by Cambridge University Press:  02 June 2009

K.E. Binns  and
T.E. Salt
K.E. Binns
Affiliation:
Department of Visual Science, Institute of Ophthalmology, Bath Street, London, EC1V 9EL, UK
T.E. Salt
Affiliation:
Department of Visual Science, Institute of Ophthalmology, Bath Street, London, EC1V 9EL, UK
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Abstract

In visual neurones of the superficial layers of the superior colliculus (SSC), repetitive stimulation causes a progressive decline in the size of the response to the stimulus, usually known as response habituation or response adaptation. A mechanism has been proposed in which habituation results from coactivation of excitatory and inhibitory neurones, and the responses of the inhibitory neurones block the response to subsequent stimulus presentations. Excitatory amino acid (EAA) neurotransmitters mediate visual responses via NMDA and non-NMDA receptors in cat SSC. We have investigated the role of these receptors in the generation of response habituation. Following the iontophoretic application of the EAA antagonists CNQX, APS or CPP, repetitive visual stimulation paradigms which normally produce response habituation no longer do so. Indeed the response to each presentation of the stimulus is similar. Intravenous administration of the dissociative anesthetic ketamine (2–10 mg/kg) had similar actions to iontophoretically applied NMDA antagonists. The data imply that intracollicular mechanisms activated by NMDA and non-NMDA receptors contribute to the generation of the inhibitory responses in SCC which lead to response habituation. Furthermore, the effects seen with ketamine anesthesia suggest that the use of ketamine in studies of sensory systems may result in the lack of habituation.

Keywords

NMDAAMPAKetamineIontophoresisExtracellular recordingCatSuperior colliculusRepetitive stimulationVision
Type
Research Articles
Information
Visual Neuroscience , Volume 12 , Issue 3 , May 1995 , pp. 563 - 571
Copyright
Copyright © Cambridge University Press 1995

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