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Bipolar cells in the zebrafish retina

Published online by Cambridge University Press:  16 November 2010

V.P. CONNAUGHTON
V.P. CONNAUGHTON*
Affiliation:
Department of Biology, American University, Washington, District of Columbia
*
*Address correspondence and reprint requests to: V.P. Connaughton, Department of Biology, American University, 4400 Massachusetts Avenue, NW, Washington, DC 20016. E-mail: vconn@american.edu
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Abstract

Zebrafish are an existing model for genetic and developmental studies due to their rapid external development and transparent embryos, which allow easy manipulation and observation of early developmental stages. The application of the zebrafish model to vision research has allowed for examination of retinal development and the characteristics of different retinal cell types, including bipolar cells. In particular, bipolar cell development, including differentiation, maturation, and gene expression, has been documented, as has physiological properties, such as voltage- and ligand-gated currents, and neurotransmitter receptor and ion channel expression. Mutant strains and transgenic lines have been used to document how bipolar cell connections and/or development may be altered, and toxicological studies examining how environmental factors may impact bipolar cell activity have been performed. The purpose of this paper was to review the existing literature on zebrafish bipolar cells, to provide a comprehensive overview of current information pertaining to this retinal cell type.

Keywords

Second-order neuronsElectrophysiologyDevelopmentDanio rerio
Type
Review Article
Information
Visual Neuroscience , Volume 28 , Issue 1 , January 2011 , pp. 77 - 93
Copyright
Copyright © Cambridge University Press 2010

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