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Angiotensinogen G(–6)A Polymorphism Is Associated With the Elevation of Blood Pressure in the Hypertensive Disorders of Pregnancy

Published online by Cambridge University Press:  21 February 2012

Soon-Sup Shim
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Jong Kwan Jun*
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. jhs0927@snu.ac.kr
Joong Shin Park
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Yoon-Mi Hur
Affiliation:
Medical Research Center, Seoul National University Hospital, Seoul, Korea.
Young Min Choi
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Bo Hyun Yoon
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Hee Chul Syn
Affiliation:
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
*
*Address for correspondence: Jong Kwan Jun, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 110-744, South Korea.

Abstract

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The objective of the present study was to determine whether angiotensinogen G(–6)A polymorphism is associated with the elevation of blood pressure (BP) in the hypertensive disorders of pregnancy in Korean population. The subjects included 201 cases with the hypertensive disorders of pregnancy and 160 healthy controls. The medical records of subjects were reviewed. Cases were classified into the four subtypes (transient hypertension, preeclampsia, chronic hypertension, and preeclampsia superimposed on chronic hypertension) by the diagnostic criteria suggested by the National High Blood Pressure Education Program Working Group. Cases were also divided into the high and low BP group by the elevation of BP (diastolic BP greater than or equal to 110 mmHg). Maternal angiotensinogen G(–6)A polymorphism was determined by restriction fragment length polymorphism. Frequencies of AA genotype were significantly higher in the high than in the low BP group in the preeclampsia, superimposed preeclampsia, and the combined group (N = 201), suggesting that the angiotensinogen G(–6)A allele was significantly associated with the elevation of BP in the hypertensive disorders of pregnancy among South Korean women. The present findings imply that the elevation of BP can serve as an endophenotype for a spectrum of hypertensive conditions in pregnancy.

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