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The Impact of Assisted Hatching on Monozygotic Twinning is Related to Female Age and Insemination Method: A New Perspective

Published online by Cambridge University Press:  29 September 2022

Chengjun Liu
Affiliation:
Beijing Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Beijing Dairy Cattle Center, Beijing, China College of Animal Sciences, Jilin University, Changchun, China
Ketong Su
Affiliation:
Reproductive Medical Center, Zhanjiang Jiuhe Hospital, Zhanjiang, China
Gensheng Liu
Affiliation:
Reproductive Medical Center, Tianjin IVF Hospital, Tianjin, China
Wei Shang
Affiliation:
Reproductive Medical Center, The Sixth Medical Center of PLA General Hospital, Beijing, China
Xuefang Wang
Affiliation:
Reproductive Medical Center, Zhanjiang Jiuhe Hospital, Zhanjiang, China
Chunjin Li
Affiliation:
Beijing Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Beijing Dairy Cattle Center, Beijing, China
Lu Chen*
Affiliation:
Beijing Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Key Laboratory of Dairy Cattle Genetic, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Beijing Dairy Cattle Center, Beijing, China
Xu Zhou*
Affiliation:
College of Animal Sciences, Jilin University, Changchun, China
*
Authors for correspondence: Lu Chen, Email: luchen@jlu.edu.cn; Xu Zhou, Email: xzhou65@vip.sina.com
Authors for correspondence: Lu Chen, Email: luchen@jlu.edu.cn; Xu Zhou, Email: xzhou65@vip.sina.com
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Abstract

Whether assisted hatching (AH) is associated with a higher incidence of monozygotic twinning (MZT) in women undergoing assisted reproductive technology remains controversial; the aim of the study was to demonstrate the relationship between AH and MZT. A total of 8900 clinical pregnancies were selected among embryo transfer cycles from January 2011 to October 2019. Women receiving day (D) 3 embryos were divided into groups A–C: group A (n = 1651) and group B (n = 1045) included women aged ≤37 or ≥38 years, respectively, with zona pellucida (ZP) thinning; group C (n = 3865) included women aged ≤37 years without AH. Women aged ≤37 years who underwent blastocyst transfer and/or blastocyst ZP breaching were included in group D (n = 2339). The incidence of MZT was compared among groups A, B and C, and between groups C and D. The incidence of MZT in group B (2.2%) was significantly higher than in group A (1.0%), especially following intracytoplasmic sperm injection (ICSI), while the incidence of MZT in group A (1.0%) was significantly lower than in group C (2.2%). The MZT rate with in vitro fertilization was higher in group D (2.8%) than in group C (2.2%), but the MZT rate following ICSI was not significantly different between the two groups. ZP thinning of D3 embryos may increase the risk of MZT in older women (≥38 years), but decrease it in younger women (≤37 years). ZP breaching may be useful to reduce the incidence of MZT in ICSI-generated blastocysts.

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Article
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of International Society for Twin Studies

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Footnotes

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Chengjun Liu and Ketong Su contributed equally to the article.

References

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