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Differences and Correlation Analysis of Birth Weight and Overweight/Obesity in Shanghai Twin Cohort

Published online by Cambridge University Press:  01 March 2021

Ping Liao
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Wen-Jing Wang
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Hui-Ting Yu
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Jia-Jie Zang
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Nai-Si Qian
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Xin He
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China
Wen-Jing Gao
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Can-Qing Yu
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Li-Ming Li
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Fan Wu
Affiliation:
Department of Functional Medicine, Department of Non-Communicable Diseases and Injuries, Shanghai Municipal Center for Disease Control and Prevention/Shanghai Institutes of Preventive Medicine, Shanghai, China Shanghai Medical College of Fudan University, Shanghai, China
Corresponding
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Abstract

The objective of this study was to analyze differences in birth weight and overweight/obesity in a Shanghai twin cohort. We also wanted to study their association and explore possible risk factors for the discordance of overweight/obesity within twins. This was an internal case–control study designed for twins. The 2012 Shanghai Twin Registration System baseline survey data of a total of 3417 twin pairs were statistically analyzed using SPSS22 software. Results show that the body mass index (BMI) of the Shanghai twin population increased with age. Twins with a high birth weight had a higher BMI and a higher rate of overweight and obesity; 0- to 6-year-old twins, male twins and dizygotic (DZ) twins had higher rates of overweight/obesity than other groups. The greater the discordant birth weight rate of twins, the more obvious the difference in BMI (p < .05). There was a significant difference in overweight/obesity between twins with a relative difference of birth weight ≥15% in DZ twins (p < .05). DZ twins, male twins and 0- to 6-year-old twins were more likely to be discordant in overweight/obese than others. The discordant birth weight within twins was not a risk factor for discordant overweight/obesity. However, attention should be paid to childhood obesity, and appropriate interventions should be made at the appropriate time. Genetics may play an important role in the occurrence and development of overweight/obesity. In conclusion, discordant growth and development in the uterus early in life may not lead to discordant weight development in the future.

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© The Author(s), 2021. Published by Cambridge University Press

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