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A Comparison of Preterm Birth Rate and Growth from Birth to 18 Years Old between in Vitro Fertilization and Spontaneous Conception of Twins

Published online by Cambridge University Press:  20 September 2021

Yali Zhang
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Xuanming Hong
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Wenjing Gao*
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Jun Lv
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Canqing Yu
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Shengfeng Wang
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Tao Huang
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Dianjianyi Sun
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Chunxiao Liao
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Zengchang Pang
Affiliation:
Qingdao Center for Disease Control and Prevention, Qingdao, China
Min Yu
Affiliation:
Zhejiang Center for Disease Control and Prevention, Hangzhou, China
Hua Wang
Affiliation:
Jiangsu Center for Disease Control and Prevention, Nanjing, China
Xianping Wu
Affiliation:
Sichuan Center for Disease Control and Prevention, Chengdu, China
Zhong Dong
Affiliation:
Beijing Center for Disease Control and Prevention, Beijing, China
Fan Wu
Affiliation:
Shanghai Center for Disease Control and Prevention, Shanghai, China
Guohong Jiang
Affiliation:
Tianjin Center for Disease Control and Prevention, Tianjin, China
Xiaojie Wang
Affiliation:
Qinghai Center for Disease Control and Prevention, Xining, China
Yu Liu
Affiliation:
Heilongjiang Agricultural Center for Disease Control and Prevention, Harbin, China
Jian Deng
Affiliation:
Handan Center for Disease Control and Prevention, Handan, China
Lin Lu
Affiliation:
Yunnan Center for Disease Control and Prevention, Kunming, China
Weihua Cao
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
Liming Li*
Affiliation:
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
*
Authors for correspondence: Wenjing Gao, Email: pkuepigwj@126.com; Liming Li, Email: lmlee@vip.163.com
Authors for correspondence: Wenjing Gao, Email: pkuepigwj@126.com; Liming Li, Email: lmlee@vip.163.com
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Abstract

The aim of the present study was to compare the rate of preterm birth (PTB) and growth from birth to 18 years between twins conceived by in vitro fertilization (IVF) and twins conceived by spontaneous conception (SC) in mainland China. The retrospective cohort study included 1164 twins resulting from IVF and 25,654 twins conceived spontaneously, of which 494 from IVF and 6338 from SC were opposite-sex twins. PTB and low birth weight (LBW), and growth, including length/height and weight, were compared between the two groups at five stages: infancy (0 year), toddler period (1–2 years), preschool (3–5 years), primary or elementary school (6–11 years), and adolescence (10–18 years). Few statistically significant differences were found for LBW and growth between the two groups after adjusting for PTB and other confounders. Twins born by IVF faced an increased risk of PTB compared with those born by SC (adjusted odds ratio [aOR] 8.21, 95% confidence interval [CI] [3.19, 21.13], p < .001 in all twins and aOR 10.12, 95% CI [2.32, 44.04], p = .002 in opposite-sex twins). Twins born by IVF experienced a similar growth at five stages (0–18 years old) when compared with those born by SC. PTB risk, however, is significantly higher for twins conceived by IVF than those conceived by SC.

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Articles
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© The Author(s), 2021. Published by Cambridge University Press

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References

Adamson, G. D., de Mouzon, J., Chambers, G. M., Zegers-Hochschild, F., Mansour, R., Ishihara, O., Banker, M., & Dyer, S. (2018). International committee for monitoring assisted reproductive technology: world report on assisted reproductive technology, 2011. Fertility and Sterility, 110, 10671080.CrossRefGoogle ScholarPubMed
Bai, F., Wang, D. Y., Fan, Y. J., Qiu, J., Wang, L., Dai, Y., & Song, L. (2020). Assisted reproductive technology service availability, efficacy and safety in mainland China: 2016. Human Reproduction, 35, 446452.CrossRefGoogle ScholarPubMed
Barda, G., Gluck, O., Mizrachi, Y., & Bar, J. (2017). A comparison of maternal and perinatal outcome between in vitro fertilization and spontaneous dichorionic-diamniotic twin pregnancies. Journal of Maternal-Fetal & Neonatal Medicine, 30, 29742977.CrossRefGoogle ScholarPubMed
Barker, D. J. P. (1998). In utero programming of chronic disease. Clinical Science, 95, 115128.CrossRefGoogle ScholarPubMed
Bay, B., Lyngsø, J., Hohwü, L., & Kesmodel, U. S. (2019). Childhood growth of singletons conceived following in vitro fertilisation or intracytoplasmic sperm injection: A systematic review and meta-analysis. BJOG, 126, 158166.CrossRefGoogle ScholarPubMed
Calhaz-Jorge, C., de Geyter, C., Kupka, M. S., de Mouzon, J., Erb, K., Mocanu, E., Motrenko, T., Scaravelli, G., Wyns, C., & Goossens, V. (2016). Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. Human Reproduction, 31, 16381652.Google ScholarPubMed
Carter, E. B., Bishop, K. C., Goetzinger, K. R., Tuuli, M. G., & Cahill, A. G. (2015). The impact of chorionicity on maternal pregnancy outcomes. American Journal of Obstetrics and Gynecology, 213, 390.e1–7.Google ScholarPubMed
Eriksson, J. G., Forsen, T., Tuomilehto, J., Winter, P. D., Osmond, C., & Barker, D. J. (1999). Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ, 318, 427431.CrossRefGoogle ScholarPubMed
Farhi, A., Reichman, B, Boyko, V., Hourvitz, A., Ron-El, R., & Lerner-Geva, L. (2013). Maternal and neonatal health outcomes following assisted reproduction. Reproductive Biomedicine Online, 26, 454461.CrossRefGoogle ScholarPubMed
Fujii, M., Matsuoka, R., Bergel, E., van der Poel, S., & Okai, T. (2010). Perinatal risk in singleton pregnancies after in vitro fertilization. Fertility and Sterility, 94, 21132117.CrossRefGoogle ScholarPubMed
Gao, W., Cao, W., Lv, J., Yu, C., Wu, T., Wang, S., Meng, L., Wang, D., Wang, Z., Pang, Z., Yu, M., Wang, H., Wu, X., Dong, Z., Wu, F., Jiang, G., Wang, X., Liu, Y., Deng, J., Lu, L., & Li, L. (2019). The Chinese National Twin Registry: A ‘gold mine’ for scientific research. Journal of Internal Medicine, 286, 299308.CrossRefGoogle ScholarPubMed
Hack, K. E. A., Vereycken, M. E. M. S., Torrance, H. L., Koopman-Esseboom, C., & Derks, J. B. (2018). Perinatal outcome of monochorionic and dichorionic twins after spontaneous and assisted conception: A retrospective cohort study. Acta Obstetricia et Gynecologica Scandinavica, 97, 717726.CrossRefGoogle ScholarPubMed
Hansen, M., Kurinczuk, J. J., de Klerk, N., Burton, P., & Bower, C. (2012). Assisted Reproductive Technology and Major Birth Defects in Western Australia. Obstetrics and Gynecology, 120, 852863.CrossRefGoogle ScholarPubMed
Koivurova, S., Hartikainen, A. L., Sovio, U., Gissler, M., Hemminki, E., & Järvelin, M. R. (2003). Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Human Reproduction, 18, 23282336.CrossRefGoogle ScholarPubMed
Kuivasaari-Pirinen, P., Raatikainen, K., Hippeläinen, M., & Heinonen, S. (2012). Adverse outcomes of IVF/ICSI pregnancies vary depending on aetiology of infertility. ISRN Obstetrics and Gynecology, 2012, 451915.CrossRefGoogle ScholarPubMed
Lee, S. H., Lee, M. Y., Chiang, T. L., Lee, M. S., & Lee, M. C. (2010). Child growth from birth to 18 months old born after assisted reproductive technology ¾ Results of a national birth cohort study. International Journal of Nursing Studies, 47, 11591166.CrossRefGoogle Scholar
Lei, L. L., Lan, Y. L., Wang, S. Y., Feng, W., & Zhai, Z. J. (2019). Perinatal complications and live-birth outcomes following assisted reproductive technology: a retrospective cohort study. Chinese Medical Journal, 132, 24082416.CrossRefGoogle ScholarPubMed
Ombelet, W., Cooke, I., Dyer, S., Serour, G., & Devroey, P. (2008). Infertility and the provision of infertility medical services in developing countries. Human Reproduction Update, 14, 605621.CrossRefGoogle ScholarPubMed
Penava, D., & Natale, R. (2004). An association of chorionicity with preterm twin birth. Journal of Obstetrics and Gynaecology Canada, 26, 571574.CrossRefGoogle ScholarPubMed
Pinborg, A., Loft, A., Rasmussen, S., Schmidt, L., Langhoff-Roos, J., Greisen, G., & Andersen, A. N. (2004). Neonatal outcome in a Danish national cohort of 3438 IVF/ICSI and 10,362 non-IVF/ICSI twins born between 1995 and 2000. Human Reproduction, 19, 435441.CrossRefGoogle Scholar
Qin, J. B., Sheng, X. Q., Wang, H., Chen, G. C., Yang, J., Yu, H., & Yang, T. B. (2017). Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization/intracytoplasmic sperm injection among multiple births: A systematic review and meta-analysis based on cohort studies. Archives of Gynecology and Obstetrics, 295, 577597.CrossRefGoogle ScholarPubMed
Qin, J. B., Wang, H., Sheng, X., Xie, Q., & Gao, S. (2016). Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: A systematic review and meta-analysis. Fertility and Sterility, 105, 11801192.CrossRefGoogle ScholarPubMed
Sherry, B., Jefferds, M. E., & Grummer-Strawn, L. M. (2007). Accuracy of adolescent self-report of height and weight in assessing overweight status: A literature review. Archives of Pediatrics & Adolescent Medicine, 161, 11541161.CrossRefGoogle ScholarPubMed
Simões, T., Queirós, A., Marujo, A. T., Valdoleiros, S., Silva, P., & Blickstein, I. (2015). Outcome of monochorionic twins conceived by assisted reproduction. Fertility and Sterility, 104, 629632.CrossRefGoogle ScholarPubMed
Steptoe, P. C., & Edwards, R. G. (1978). Birth after the reimplantation of a human embryo. Lancet, 2, 366.CrossRefGoogle ScholarPubMed
Sunderam, S., Kissin, D. M., Zhang, Y., Folger, S. G., Boulet, S. L., Warner, L., Callaghan, W. M., & Barfield, W. D. (2019). Assisted reproductive technology surveillance ¾ United States, 2016. Morbidity and Mortality Weekly Report (MMWR) Surveillance Summaries, 68, 123.Google Scholar
van Beijsterveldt, C. E., Bartels, M., & Boomsma, D. I. (2011). Comparison of naturally conceived and IVF-DZ twins in the Netherlands Twin Registry: A developmental study. Journal of Pregnancy, 2011, 517614.CrossRefGoogle ScholarPubMed
van de Mheen, L., Everwijn, S. M., Knapen, M. F., Oepkes, D., Engels, M., Manten, G. T., Zondervan, H., Wirjosoekarto, S. A., van Vugt, J. M., Erwich, J. J., Nij Bijvank, S. W., Ravelli, A., Heemelaar, S., van Pampus, M. G., de Groot, C. J., Mol, B. W., & Pajkrt, E. (2014). The effectiveness of multifetal pregnancy reduction in trichorionic triplet gestation. American Journal of Obstetrics and Gynecology, 211, 536.e1-6.CrossRefGoogle ScholarPubMed
Yang, X., Li, Y., Li, C., & Zhang, W. (2014). Current overview of pregnancy complications and live-birth outcome of assisted reproductive technology in mainland China. Fertility and Sterility, 101, 385391.CrossRefGoogle ScholarPubMed
Zegers-Hochschild, F., Schwarze, J. E., Crosby, J. A., Musri, C., & Urbina, M. T. (2019). Assisted reproductive techniques in Latin America: The Latin American Registry 2016. Reproductive Biomedicine Online, 39, 452460.CrossRefGoogle ScholarPubMed
Zhu, L., Zhang, Y., Liu, Y., Zhang, R., Wu, Y., Huang, Y., Liu, F., Li, M., Sun, S., Xing, L., Zhu, Y., Chen, Y., Xu, L., Zhou, L., Huang, H., & Zhang, D. (2016). Maternal and live-birth outcomes of pregnancies following assisted reproductive technology: A retrospective cohort study. Scientific Reports, 6, 35141.CrossRefGoogle ScholarPubMed
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