Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-18T10:30:57.323Z Has data issue: false hasContentIssue false
  • English
  • Français

Urinary Monoamine Oxidase Inhibitor and Benzodiazepine Withdrawal

Published online by Cambridge University Press:  29 January 2018

H. Petursson ,
S. K. Bhattacharya ,
Vivette Glover ,
M. Sandler  and
M. H. Lader
H. Petursson
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
S. K. Bhattacharya
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG
Vivette Glover
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG
M. Sandler
Affiliation:
Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, Goldhawk Road, London W6 0XG
M. H. Lader
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
Get access Rights & Permissions [Opens in a new window]

Summary

A characteristic withdrawal reaction following the cessation of long-term benzodiazepine treatment in seven patients was accompanied by a significant increase in output of urinary monoamine oxidase inhibitor. This finding provides further support for the concept that the urinary inhibitor excretion pattern may be related to stress or anxiety.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 140 , Issue 1 , January 1982 , pp. 7 - 10
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Braestrup, C., Nielsen, M. & Olsen, C. E. (1980) Urinary and brain β-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. Proceedings of the National Academy of Sciences, USA, 77, 2288–92.CrossRefGoogle ScholarPubMed
Buckholz, N. S. & Boggan, W. O. (1977) Monoamine oxidase inhibition in brain and liver produced by β-carbolines: structure-activity relationships and substrate specificity. Biochemical Pharmacology, 26, 1991–6.Google Scholar
Glover, V., Bhattacharya, S. K., Sandler, M. & File, S. E. (1981) Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor. Nature, London, 292, 347–9.CrossRefGoogle ScholarPubMed
Glover, V., Reveley, M. A. & Sandler, M. (1980) A monoamine oxidase inhibitor in human urine. Biochemical Pharmacology, 29, 467–70.CrossRefGoogle ScholarPubMed
Glover, V., Sandler, M., Grant, E., Rose, F. C., Orton, D., Wilkinson, M. & Stevens, D. (1977) Transitory decrease in platelet monoamine oxidase activity during migraine attacks, Lancet, i, 391–3.Google Scholar
Petursson, H. & Lader, M. H. (1981) Withdrawal from long-term benzodiazepine treatment. British Medical Journal, 283, 643–5.CrossRefGoogle ScholarPubMed
Petursson, H., Reveley, M. A., Glover, V. & Sandler, M. Urinary monoamine oxidase inhibitor in psychiatric illness. Psychiatry Research, in press.Google Scholar
Rastogi, R. B., Lapierre, Y. D. & Singhal, R. L. (1978) Synaptosomal uptake of norepinephrine and 5-hydroxytryptamine and synthesis of catecholamines during benzodiazepine treatment. Canadian Journal of Physiology and Pharmacology, 56, 777–84.CrossRefGoogle ScholarPubMed
Rommelspacher, H., Nanz, C., Borbe, H. O., Fehske, K. J., Muller, W. E. & Wollert, U. (1980) 1-Methyl-β-carboline (harmane), a potent endogenous inhibitor of benzodiazepine receptor binding. Naunyn-Schmiedeberg's Archives of Pharmacology, 314, 97—100.CrossRefGoogle ScholarPubMed
Sandler, M., Glover, V., Elsworth, J. D., Lewinsohn, R. & Reveley, M. A. (1979) Monoamine oxidase and its inhibition: some clinical implications. In Monoamine Oxidase: Structure, Function and Altered Functions (ed. Singer, T. P., von Korff, R. W. and Murphy, D. L.). New York: Academic Press, pp 447–56.Google Scholar
Skolnick, P., Goodwin, F. K. & Paul, S. M. (1979) A rapid and sensitive radio-receptor assay for benzodiazepine in plasma. Archives of General Psychiatry, 36, 78—80.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.