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Sodium Valproate in Schizophrenia: Some Biochemical Correlates

Published online by Cambridge University Press:  29 January 2018

A. Lautin ,
B. Angrist ,
M. Stanley ,
S. Gershon ,
K. Heckl  and
M. Karobath
A. Lautin
Affiliation:
Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY. 10016
B. Angrist
Affiliation:
Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY. 10016
M. Stanley
Affiliation:
Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY. 10016
S. Gershon
Affiliation:
Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY. 10016
K. Heckl
Affiliation:
Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY. 10016
M. Karobath
Affiliation:
Department of Biochemical Psychiatry, Psychiatrische Universitätsklinik, Lazarettgasse 14, Wien, Austria A1090
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Summary

Sodium valproate given in doses of 750–3000 mg daily to eight schizophrenic patients produced a qualitatively similar increase in symptoms in five. CSF showed no significant change in γ-aminobutyric acid or methoxy hydroxyphenyl glycol, but homovanillic acid increased non-significantly in five patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 3 , September 1980 , pp. 240 - 244
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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