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A Neuroendocrine Study of Stereotactic Sub-Caudate Tractotomy

Published online by Cambridge University Press:  29 January 2018

T. H. Corn ,
A. Honig ,
C. Thompson ,
P. K. Bridges ,
J. R. Bartlett  and
S. A. Checkley
T. H. Corn
Affiliation:
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
A. Honig
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, Shooters Hill Road, London SE18 4IW
C. Thompson
Affiliation:
Institute of Psychiatry, London SE5 8AF
P. K. Bridges
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London SE18 4IW
J. R. Bartlett
Affiliation:
Geoffrey Knight Psychosurgical Unit, Brook General Hospital, London SE18 4IW
S. A. Checkley
Affiliation:
The Maudsley Hospital, Denmark Hill, London SE5 8AZ
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Summary

The growth hormone and hypotensive responses to clonidine have been measured in six drug free severely depressed patients before, and at two weeks after, the surgical procedure of stereotactic sub-caudate tractotomy. The responses were unaltered two weeks after operation, by which time a small clinical improvement was evident. These findings are discussed in relation to central a adrenoceptor functions in depression, and the effect upon this of antidepressant treatment.

Type
Papers
Information
The British Journal of Psychiatry , Volume 144 , Issue 4 , April 1984 , pp. 417 - 420
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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References

Bartlett, J., Bridges, P. & Kelly, D. (1981) Contemporary indications for psychosurgery. British Journal of Psychiatry, 138, 507–11.Google Scholar
Beck, A., Ward, C., Mendolson, M., Mark, J. & Erbaugh, J. (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 561–71.Google Scholar
Carroll, B. J., Feinberg, M., Greden, J. F., Tarika, J., Albala, A. A., Haskett, R. F., James, N. McI., Kronfol, Z., Lohr, N., Steiner, M., De Vigne, J. P. & Young, E. (1981) A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22.Google Scholar
Charney, D. S., Heninger, G. R., Sternberg, D. E., Harstad, K. M., Giddings, S. & Landis, D. H. (1982) Adrenergic receptor sensitivity in depression. Effects of clonidine in depressed patients and healthy subjects. Archives of General Psychiatry, 39, 290–4.CrossRefGoogle ScholarPubMed
Checkley, S. A. (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychological Medicine, 10, 35–53.CrossRefGoogle Scholar
Checkley, S. A., Slade, A. P. & Shur, E. (1981a) Growth hormone and other responses to clonidine in patients with endogenous depression. British Journal of Psychiatry, 138, 51–5.CrossRefGoogle ScholarPubMed
Checkley, S. A., Slade, A. P., Shur, E. & Dawling, S. (1981b) A pilot study of the mechanism of action of desipramine. British Journal of Psychiatry, 138, 248–51.Google Scholar
Eriksson, E., Eden, S. & Modigh, K. (1982) Up-and down-regulation of central postsynaptic α2 receptors reflected in the growth hormone response to clonidine in reserpine pre-treated rats. Psychopharmacology, 77, 327–31.Google Scholar
Glass, I. B., Checkley, S. A., Shur, E. & Dawling, S. (1982) The effect of desipramine upon central adrenergic function in depressed patients. British Journal of Psychiatry, 141, 372–6.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–96.Google Scholar
Kelly, D. & Mitchell-Heggs, N. (1973) Stereotactic limbic leucotomy — a follow-up study of thirty patients. Postgraduate Medical Journal, 49, 865–82.Google Scholar
Knight, G. C. (1964) The orbital cortex as an objective in the surgical treatment of mental illness: the results of 450 cases of open operation and the development of the stereotactic approach. British Journal of Surgery, 51, 114–24.Google Scholar
Krulich, L., Mayfield, M. A., Steele, M. K., McMillen, B. A., McCann, S. M. & Koenig, J. I. (1982) Differential effects of pharmacological manipulations of central α1 and α2 adrenergic receptors on the secretion of thyrotropin and growth hormone in male rats. Endocrinology, 110, 796–804.Google Scholar
Lovinger, R., Holland, J., Kaplan, S., Grumbach, M. M., Boryczka, A. T., Shackleford, R., Salmon, J., Reid, I. A. & Ganong, W. F. (1976) Pharmacological evidence for stimulation of growth hormone secretion by a central noradrenergic system in dogs. Neuroscience, 1, 443–50.Google Scholar
McWilliam, J., Meldrum, B. S. & Checkley, S. A. (1981) Enhanced growth hormone response to clonidine after repeated electroconvulsive shock in a primate species. Psychoneuroendocrinology, 6, 77–9.Google Scholar
McWilliam, J., Meldrum, B. S. & Checkley, S. A. (1982) Changes in noradrenergic neuroendocrine responses following repeated seizures and the mechanism of action of ECT. Psychopharmacology, 77, 53–7.Google Scholar
Matussek, N., Ackenheil, M., Hippius, H., Muller, F., Schroder, H. Th., Schultes, H. & Wasilewski, , (1980) Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Research, 2, 25–36.Google Scholar
Newcombe, R. (1975) The lesion in stereotactic subcaudate tractotomy. British Journal of Psychiatry, 126, 478–81.Google Scholar
Rudolph, C. D., Kaplan, S. L. & Ganong, W. F. (1980) Sites at which clonidine acts to affect blood pressure and the secretion of renin, growth hormone and ACTH. Neuroendocrinology, 31, 121–8.Google Scholar
Siever, L. J., Uhde, T. W., Silberman, E. K., Jimerson, D. G., Aloi, J. A., Post, R. M. & Murphy, D. L. (1982) Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatry Research, 6, 171–83.Google Scholar
Slade, A. P. & Checkley, S. A. (1980) A neuroendocrine study of the mechanism of action of ECT. British Journal of Psychiatry, 137, 217–21.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, Third edition, Biometrics Research, New York State Psychiatric Institute, New York 10032.Google Scholar
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