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Mianserin Hydrochloride: A Novel Antidepressant

Published online by Cambridge University Press:  29 January 2018

Alec Coppen ,
Ramesh Gupta ,
Stuart Montgomery ,
Karabi Ghose ,
John Bailey ,
Bruce Burns  and
J. J. de Ridder
Alec Coppen
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Ramesh Gupta
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Stuart Montgomery
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Karabi Ghose
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
John Bailey
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Bruce Burns
Affiliation:
Hollymoor Hospital, Birmingham
J. J. de Ridder
Affiliation:
Drug Metabolism R & D Laboratories, Organon, Oss, Holland
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Summary

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.

Type
Papers
Information
The British Journal of Psychiatry , Volume 129 , Issue 4 , October 1976 , pp. 342 - 345
Copyright
Copyright © Royal College of Psychiatrists, 1976 

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