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Genetics of Neurosis

The Effects of Sampling Variation Upon the Twin Concordance Ratio

Published online by Cambridge University Press:  29 January 2018

Svenn Torgersen*
Affiliation:
NAVF's Center for Research in Clinical Psychology, University of Oslo, PO Box 1039, Blindern, Oslo 3, Norway

Summary

In a study of 229 neurotic same-sex adult twins admitted to all psychiatric in- and out-patient clinics and mental hospitals in Norway, a statistically significant, moderately higher concordance was found for MZ than for DZ twins. When the sample was subdivided, this higher concordance for MZ pairs was true only for male twins and for twins admitted to mental hospitals. The results are compared to those from earlier studies; different findings on the importance of genetic factors in the development of neuroses may be due to differences in sample selection.

Type
Papers
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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References

Alanen, Y. O. (1966) The family in the pathogenesis of schizophrenic and neurotic disorders. Acta Psychiatrica Scandinavia, Supplement 189.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd Edition). Washington, D.C.: APA.Google Scholar
Braconi, L. (1961) Le psiconevrosi e le psicosi nei gemelli. Acta Geneticae Medicae et Gemellologiae, 10, 100–36.CrossRefGoogle Scholar
Brown, F. W. (1942) Heredity in the psychoneuroses. Proceedings of the Royal Society of Medicine, 35, 785–90.Google ScholarPubMed
Cohen, M. E. (1951) The high familial prevalence of neurocirculatory asthenia (anxiety neurosis, effort syndrome). American Journal of Human Genetics, 3, 126–58.Google ScholarPubMed
Coppen, A., Cowie, V. & Slater, E. (1965) Familial aspects of “neuroticism” and “extraversion”. British Journal of Psychiatry, 111, 7083.CrossRefGoogle ScholarPubMed
Dohrenwend, B. P. & Dohrenwend, B. S. (1976) Sex differences and psychiatric disorders. American Journal of Sociology, 81, 1447–54.CrossRefGoogle ScholarPubMed
Fleiss, J. L. (1971) Measuring nominal scale agreement among many raters. Psychological Bulletin, 76, 378–82.CrossRefGoogle Scholar
Hauge, M., Harvald, B., Fischer, M., Gotlieb-Jensen, K., Juel-Nielsen, N., Raebild, I., Shapiro, R. & Videbach, T. (1968) The Danish twin register. Acta Geneticae Medicae et Gemellologiae, 17, 315–31.CrossRefGoogle ScholarPubMed
Ihda, S. (1960) A study of neurosis by twin method (in Japanese). Psychiatria Neurologia Japenica, 63, 861–92.Google Scholar
Ihda, S. (1965) Psychiatrische Zwillingsforschung in Japan. Archiv für Psychiatrie und Zeitschrift für die gesamte Neurologie, 207, 206–20.Google ScholarPubMed
Kringlen, E. (1967) Heredity and Environment in the Functional Psychoses. London: Heinemann.Google Scholar
McInnes, R. G. (1937) Observations on heredity in neurosis. Proceedings of the Royal Society of Medicine, 30, 895904.CrossRefGoogle ScholarPubMed
Noyes, R., Clancy, J., Crowe, R., Hoenk, P. R. & Slymen, D. J. (1978) The familial prevalence of anxiety neurosis. Archives of General Psychiatry, 35, 1057–9.CrossRefGoogle ScholarPubMed
Parker, N. (1964) Twins: A psychiatric study of a neurotic group. Medical Journal of Australia, 2, 735–42.CrossRefGoogle ScholarPubMed
Pollin, W., Allen, M. G., Hoffer, A., Stabenau, J. R. & Hrubec, Z. (1969) Psychopathology in 15,909 pairs of veteran twins: Evidence for a genetic factor in the pathogenesis of schizophrenia and its relative absence in psychoneurosis. American Journal of Psychiatry, 126, 597610.CrossRefGoogle Scholar
Rutter, M. (1972) Relationships between child and adult psychiatric disorders. Acta Psychiatrica Scandinavia, 48, 321.CrossRefGoogle ScholarPubMed
Schepank, H (1973) Erb- und Umweltfaktoren bei Neurosen. Ergebnisse der Zwillingsforschung und anderer Methoden. Nervenarzt, 44, 449–59.Google Scholar
Shields, J. (1973) Heredity and psychological abnormality. in Handbook of Abnormal Psychology (ed. H. J. Eysenck). London: Pitman Medical.Google Scholar
Shields, J. & Slater, E. (1966) La similarité du diagnostic chez les jumeaux et le probléme de la spécificité biologique dans les névroses et les troubles de la personalité. L'evolution Psychiatrique, 31, 441–51.Google Scholar
Shields, J. & Slater, E. (1971) Diagnostic similarity in twins with neuroses and personality disorders. In Man, Mind and Heredity. Selected Papers of Eliot Slater on Psychiatry and Genetics (eds. J. Shields and I. I. Gottesman). Baltimore and London: The John Hopkins Press.Google Scholar
Slater, E. (1953) Psychotic and Neurotic Illnesses in Twins. Medical Research Council Special Report Series No. 278. London: Her Majesty's Stationery Office.Google Scholar
Slater, E. & Shields, J. (1969) Genetical aspects of anxiety. in Studies of Anxiety (ed. M. H. Lader). British Journal of Psychiatry Special Publication, No. 3. Ashford, Kent: Headley Brothers.Google Scholar
Torgersen, S. (1979a) The determination of twin zygosity by means of a mailed questionnaire. Acta Geneticae Medicae et Gemellologiae, 28, 225–36.Google ScholarPubMed
Torgersen, S. (1979b) The nature and origin of common phobic fears. British Journal of Psychiatry, 134, 343–51.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Forman, J. B. W. & Nee, J. (1979) DSM-III field trials: I. Initial interrater diagnostic reliability. American Journal of Psychiatry, 136, 815–17.Google ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Wing, J. K., Mann, S. A., Leff, J. P. & Nixon, J. M. (1978) The concept of a “case” in psychiatric population surveys. Psychological Medicine, 8, 203–17.CrossRefGoogle ScholarPubMed
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