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Elevated Cerebrospinal Fluid Noradrenaline in Tardive Dyskinesia

Published online by Cambridge University Press:  29 January 2018

Dilip V. Jeste ,
Dinshaw R. Doongaji  and
Markku Linnoila
Dilip V. Jeste
Affiliation:
Unit on Movement Disorders, Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, USA
Dinshaw R. Doongaji
Affiliation:
Department of Psychiatry, K.E.M. Hospital and G.S. Medical College, Bombay, India
Markku Linnoila
Affiliation:
DICBR, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland 20205, USA
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Summary

Cerebrospinal fluid was collected from 28 psychiatric (mostly schizophrenic) inpatients from Bombay, India. These included eight patients with tardive dyskinesia, five with spontaneous dyskinesia and 15 without dyskinesia. The samples were flown to the National Institute of Mental Health, Washington, D.C., where they were analyzed “blind” for concentrations of noradrenaline and several monoamine metabolites. Patients with tardive dyskinesia had significantly higher noradrenaline concentrations in the CSF as compared with the other two groups. Spontaneous dyskinesia group had significantly lower concentrations of homovanillic acid in the CSF. Our results support the hypothesis of noradrenergic hyperactivity, rather than postsynaptic dopamine receptor supersensitivity, in tardive dyskinesia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 144 , Issue 2 , February 1984 , pp. 177 - 180
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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