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Early intervention, untreated psychosis and the course of early schizophrenia

Published online by Cambridge University Press:  06 August 2018

Donald Linszen ,
Marie Lenior ,
Lieuwe de Haan ,
Peter Dingemans  and
Berthold Gersons
Donald Linszen*
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Marie Lenior
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Lieuwe de Haan
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Peter Dingemans
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
Berthold Gersons
Affiliation:
Academical Medical Centre, University of Amsterdam, The Netherlands
*
Correspondence: D. Linszen, MD, Psychiatric Centre AMC, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands
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Abstract

Background Studies have proved that early intervention can delay psychotic relapses, and prevent psychosocial deterioration in people with schizophrenia and related disorders.

Method Our study with young people with recent onset schizophrenia has shown that an intensive intervention programme had a beneficial effect on the occurrence of psychotic relapse and the course of psychotic syndromes. This effect lasted until the end of the 15-month intervention. No significant effect of the two different intervention conditions became apparent.

Results The results of a follow-up study showed that this beneficial effect did not last. Fifteen per cent of the people had a psychotic relapse during the intervention, whereas 64% relapsed during follow-up.

Conclusions These results show that referral to other mental health agencies after intervention is not sufficient and that more support is required to continue disease management, medication compliance and stress management.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 172 , Issue S33: Verging on reality , June 1998 , pp. 84 - 89
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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