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Clozapine Rechallenge after an Episode of ‘Neuroleptic Malignant Syndrome’

Published online by Cambridge University Press:  02 January 2018

Michael Weller  and
Johannes Kornhuber
Michael Weller
Affiliation:
Clinical Neuroscience Branch, Building 10, Room 3N256, Bethesda, MD 20892, USA
Johannes Kornhuber*
Affiliation:
University of Würzburg, Füchsleinstraße 15, 8700 Würzburg, Germany
*
∗Correspondence
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Abstract

Nine out of 4044 patients admitted to our institution between 1987 and 1990 suffered an episode of NMS. Neuroleptic rechallenge using clozapine for persisting psychiatric illness was tolerated by eight patients. Clozapine was discontinued in one older, high-risk patient because recurrence of NMS was anticipated. Clozapine should be considered a drug of choice for psychotic patients with a history of NMS.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 161 , Issue 6 , December 1992 , pp. 855 - 856
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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