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Central D2 Receptors and Negative Symptoms of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

J. L. Martinot ,
M. L. Paillère-Martinot ,
C. Loc'h ,
Y. Lecrubier ,
M. H. Dao-Castellana ,
F. Aubin ,
J. F. Allilaire ,
B. Mazoyer ,
B. Mazière  and
A. Syrota
J. L. Martinot*
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
M. L. Paillère-Martinot
Affiliation:
Service de psychopathologie de l'enfant et de l'adolescent
C. Loc'h
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
Y. Lecrubier
Affiliation:
INSERM U302, hôpital de la Salpêtrière, Paris
M. H. Dao-Castellana
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
F. Aubin
Affiliation:
INSERM U302, hôpital de la Salpêtrière, Paris
J. F. Allilaire
Affiliation:
Service de psychiatrie, INSERM U302
B. Mazoyer
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
B. Mazière
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
A. Syrota
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
*
∗INSERM U334, Service Hospitalier Frédéric Joliot, 4 place du général Leclerc, 91406 Orsay, France
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Abstract

Most in vivo studies of striatal D2 receptor (SD2R) density with positron emission tomography in schizophrenia have attempted to relate this variable to the diagnosis of the illness. In the present study, a relationship between SD2R and clinical dimensions of this psychosis was searched for in a highly selected group of young negative schizophrenics (8 drug-naïve and 2 drug-free). The SD2R density index measured in vivo using 76Br-bromolisuride and PET correlated negatively (r = 0.80, P < 0.01) with a psychomotor dimension of schizophrenia involving blunted affect and alogia. The mean SD2R index of the patients did not differ from that of age-matched control subjects. Therefore, this behavioural dimension accounts for the variance of the SD2R, suggesting that the striatal dopamine system modulates symptoms such as flattened affect and alogia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 1 , January 1994 , pp. 27 - 34
Copyright
Copyright © The Royal College of Psychiatrists 

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