Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T22:53:03.006Z Has data issue: false hasContentIssue false

Cognitive Functions in Manic-Depressives: Effects of Lithium and Physostigmine

Published online by Cambridge University Press:  29 January 2018

Rosemary Telford
Affiliation:
Southern General Hospital, Glasgow G51 4TF
Ernest P. Worrall
Affiliation:
University of Glasgow, Department of Psychological Medicine, Southern General Hospital, Glasgow G51 4TF

Summary

Cognitive functions were investigated in seven manic-depressive patients while on lithium, after two weeks off lithium, and after a subcutaneous injection of physostigmine while on lithium. Test performance was unaffected by lithium, but after physostigmine the I.Q. score of a shortened version of the WAIS was significantly increased.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aminoff, M. J. & Marshall, J. (1974) Treatment of Huntington's chorea with lithium carbonate. Lancet, i, 107–9.Google Scholar
Bech, P., Thomsen, J. & Rafaelsen, O. J. (1976) Long-term lithium treatment: effect on simulated driving and other psychological tests. European Journal of Clinical Pharmacology, 10, 331–5.CrossRefGoogle ScholarPubMed
Demers, R. G. & Heninger, G. R. (1971) Visual-motor performance during lithium treatment—a preliminary report. Journal of Clinical Pharmacology, 11, 274–9.Google ScholarPubMed
Drachman, D. A. & Leavitt, J. (1974) Human memory and the cholinergic system: a relationship to ageing? Archives of Neurology, 30, 113–21.Google Scholar
Gronwall, D. M. A. & Sampson, H. (1974) The Psychological Effects of Concussion. Auckland University/Oxford University Press, Auckland.Google Scholar
Friedman, M. J., Culver, C. M. & Ferrell, R. B. (1977) On the safety of long-term treatment with lithium. American Journal of Psychiatry, 134, 1123–6.Google ScholarPubMed
Judd, L. J., Hubbard, B., Janowsky, D. S., Huey, L. Y. & Takahashi, K. I. (1977) The effect of lithium carbonate on the cognitive functions of normal subjects. Archives of General Psychiatry, 34, 355–7.Google Scholar
Kusumo, K. S. & Vaughan, M. (1977) Effects of lithium salts on memory. British Journal of Psychiatry, 131, 453–7.Google Scholar
Linnoila, M., Saario, I. & Maki, M. (1974) Effect of treatment with diazepam or lithium and alcohol on psychomotor skills related to driving. European Journal of Clinical Pharmacology, 7, 337–42.Google Scholar
Marini, J. L. & Sheard, M. H. (1977) Antiaggressive effect of lithium ion in man. Acta Psychiatrica Scandinavica, 55, 269–86.Google Scholar
Muller-Oerlinghausen, B., Bauer, H., Girke, W., Kanowski, S. & Concalves, N. (1977) Impairment of vigilance and performance under lithium treatment. Studies in patients and normal volunteers. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 10, 6778.Google Scholar
Naylor, G. J., Smith, A., Boardman, L. J., Dick, D. A. T., Dick, E. G. & Dick, P. (1977) Lithium and erythrocyte membrane cation carrier studies in normal and manic-depressive subjects. Psychological Medicine, 7, 229–33.Google Scholar
Peters, B. H. & Levin, H. S. (1977) Memory enhancement after physostigmine treatment in the amnesic syndrome. Archives of Neurology, 34, 215–9.Google Scholar
Samples, J. R., Janowsky, D. S., Pechnick, R. & Judd, L. J. (1977) Lethal effects of physostigmine plus lithium in rats. Psychopharmacology, 52, 307–9.Google Scholar
Savage, R. D., Britton, P. G., Bolton, N. & Hall, E. H. (1973) Intellectual Functioning in the Aged. London: Methuen and Co. Ltd.Google Scholar
Slánská, J., Safratová, V., Vojtechovsky, M. & Skála, J. (1971) The effect of physostigmine on the perception and consolidation phase of memory and learning in alcoholics. Activitas Nervosa Superior (Praha), 13, 201–2.Google Scholar
Slánská, J., Vojtechovsky, M. & Votava, Z. (1972) The influence of physostigmine on individual phases of learning in man. Activitas Nervosa Superior (Praha), 14, 110–11.Google ScholarPubMed
Vizi, E. S., Illes, P., Ronai, A. & Knoll, J. (1972) The effect of lithium on acetylcholine release and synthesis. Neuropharmacology, 11, 521–30.Google Scholar
Worrall, E. P., Moody, J. P. & Naylor, G. J. (1975) Lithium in non-manic-depressives: antiaggressive effect and red blood cell lithium values. British Journal of Psychiatry, 126, 464–8.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.