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Addressing the challenges of cellular delivery and bioavailability of peptide nucleic acids (PNA)

Published online by Cambridge University Press:  06 April 2006

Peter E. Nielsen
Affiliation:
Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Blegdamsvej 3c, 2200 Copenhagen N, Denmark

Abstract

1. Introduction 345

2. Peptide nucleic acid (PNA) 346

3. ‘Cell penetrating peptides’ (CPPs) 346

4. Endosomal escape 347

5. Cellular delivery of PNA 347

6.In vivobioavailability of PNA 349

7. References 350

Recent results on the cellular delivery of antisense peptide nucleic acids (PNA) via peptide conjugation is briefly discussed, in particular in the context of endosomal entrapment and escape.

Type
Essay
Copyright
© 2006 Cambridge University Press

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