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An observational study on Ca supplementation and dietary intake during pregnancy on low birth weight and small for gestational age

Published online by Cambridge University Press:  04 November 2020

Wei Dai
Affiliation:
Department of Pharmacy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, China
Xiaohui Deng
Affiliation:
Department of Healthcare Associated Infection Control, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, China
Lanlan Li
Affiliation:
Department of Pharmacy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, China
Jie Qiu
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Baohong Mao
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Yawen Shao
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Sijuan Xu
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Tao Yang
Affiliation:
Department of Pharmacy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu Province, China
Xiaochun He
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Hongmei Cui
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Xiaojuan Lin
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Ling Lv
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Zhongfeng Tang
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Qing Liu
Affiliation:
Department of Obstetrics and Gynecology, Gansu Provincial Maternity and Child Care Hospital, No.143, Qilihe North Street, Qilihe District, Lanzhou 730050, Gansu Province, China
Corresponding
E-mail address:

Abstract

Objective:

To evaluate the effects of dietary Ca intake and Ca supplementation during pregnancy on low birth weight (LBW) and small for gestational age (SGA) infants.

Design:

A birth cohort study was conducted in 2010–2012 at the Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.

Setting:

A birth cohort study.

Participants:

Totally, 9595 pregnant women who came to the hospital for delivery at 20 weeks of gestation or more, and who were 18 years of age or older.

Results:

Compared with non-users, Ca supplement users had a reduced risk of LBW infants (OR = 0·77, 95 % CI: 0·63, 0·95) and a reduced risk of nulliparous women giving birth to LBW infants (OR = 0·75, 95 % CI: 0·58, 0·98) (P < 0·05). More specifically, both the use of Ca supplement before conception and during pregnancy (OR = 0·44, 95 % CI: 0·19, 0·99) and during pregnancy only (OR = 0·80, 95 % CI: 0·65, 0·99) had the main effect of reducing risk of nulliparous women giving birth to LBW infants (P < 0·05). There was no association between Ca supplementation and SGA (OR = 0·87, 95 % CI: 0·75, 1·01) (P > 0·05). However, higher dietary Ca intake during pregnancy decreases the risk of both LBW (quartile 2: OR = 0·72, 95 % CI: 0·55, 0·94; quartile 3: OR = 0·68, 95 % CI: 0·50, 0·62) and SGA infants (quartile 2: OR = 0·77, 95 % CI: 0·63, 0·95; quartile 3: OR = 0·71, 95 % CI: 0·57, 0·88, quartile 4: OR = 0·71, 95 % CI: 0·57, 0·88) (P < 0·05).

Conclusions:

Ca supplementation and adequate dietary intake of Ca during pregnancy are associated with a decreased risk of LBW infants born to nulliparous women.

Type
Research paper
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

Wei Dai, Xiaohui Deng & Lanlan Li are co-first authors.

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