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Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease

Published online by Cambridge University Press:  13 February 2002

THOMAS FRODL
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
HARALD HAMPEL
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
GEORG JUCKEL
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
KATHARINA BÜRGER
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
FRANK PADBERG
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
ROLF R. ENGEL
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
HANS-JÜRGEN MÖLLER
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
ULRICH HEGERL
Affiliation:
Department of Psychiatry, Section of Clinical Neurophysiology, Dementia Research Section and Memory Clinic, Ludwig-Maximilians University Munich, Germany
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Abstract

Accurate and early diagnosis of Alzheimer's Disease (AD) with reliable and noninvasive methods is of great importance for clinical practice as effective and specific antidementive therapies become available. The aim of the study was to evaluate the clinical relevance of event-related P300 in the early diagnosis of AD. Thirty patients with AD, 26 patients with mild cognitive impairment (MCI) from our Memory Clinic and 26 age-matched healthy controls (HC) were studied with event-related P300 potentials. Amplitudes of temporo-basal dipoles (TB-P300) were significantly diminished in AD compared to HC and MCI. Furthermore, latencies of temporo-superior dipoles (TS-P300) were significantly prolonged in AD compared with HC. Sensitivity was 90.0% for the differentiation of patients with AD from HC (specificity 79.1%) using reduced TB-P300 amplitudes and prolonged TS-P300 latencies. Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD.

Type
Research Article
Copyright
2002 Society for Psychophysiological Research

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