Hostname: page-component-7c8c6479df-5xszh Total loading time: 0 Render date: 2024-03-29T09:49:15.432Z Has data issue: false hasContentIssue false

Understanding the psychological therapy treatment outcomes for young adults who are not in education, employment, or training (NEET), moderators of outcomes, and what might be done to improve them

Published online by Cambridge University Press:  25 November 2021

Joshua E. J. Buckman*
Affiliation:
Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational & Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK iCope – Camden & Islington NHS Foundation Trust, St Pancras Hospital, London NW1 0PE, UK
Joshua Stott
Affiliation:
ADAPT lab, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, UK
Nicole Main
Affiliation:
Let's Talk IAPT – Barnet, Enfield & Haringey Psychological Therapies Service, Barnet, Enfield & Haringey Mental Health Trust, London, UK
Daniela M. Antonie
Affiliation:
Newham Talking Therapies – East London NHS Foundation Trust, Vicarage Lane Health Centre, Stratford, London E15 4ES, UK
Satwant Singh
Affiliation:
Waltham Forest Talking Therapies – North East London Foundation Trust, Thorne House, London E11 4HU, UK
Syed A. Naqvi
Affiliation:
Barking & Dagenham and Havering IAPT Services – North East London Foundation Trust, Church Elm Lane Health Centre, Dagenham, Essex RM10 9RR, UK
Elisa Aguirre
Affiliation:
Redbridge Talking Therapies Service, North East London NHS Foundation Trust, London, UK
Jon Wheatley
Affiliation:
Talk Changes: City & Hackney IAPT Service, Homerton University Hospital NHS Foundation Trust, London, UK
Mirko Cirkovic
Affiliation:
Talk Changes: City & Hackney IAPT Service, Homerton University Hospital NHS Foundation Trust, London, UK
Judy Leibowitz
Affiliation:
iCope – Camden & Islington NHS Foundation Trust, St Pancras Hospital, London NW1 0PE, UK
John Cape
Affiliation:
Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational & Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK
Stephen Pilling
Affiliation:
Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational & Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK
Rob Saunders
Affiliation:
Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational & Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK
*
Author for correspondence: Joshua E J Buckman, E-mail: joshua.buckman@ucl.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Background

To determine: whether young adults (aged 18–24) not in education, employment or training (NEET) have different psychological treatment outcomes to other young adults; any socio-demographic or treatment-related moderators of differential outcomes; and whether service-level changes are associated with better outcomes for those who are NEET.

Methods

A cohort was formed of 20 293 young adults treated with psychological therapies in eight Improving Access to Psychological Therapies services. Pre-treatment characteristics, outcomes, and moderators of differential outcomes were compared for those who were and were not NEET. Associations between outcomes and the following were assessed for those that were NEET: missing fewer sessions, attending more sessions, having a recorded diagnosis, and waiting fewer days between referral and starting treatment.

Results

Those who were NEET had worse outcomes: odds ratio (OR) [95% confidence interval (CI)] for reliable recovery = 0.68 (0.63–0.74), for deterioration = 1.41 (1.25–1.60), and for attrition = 1.31 (1.19–1.43). Ethnic minority participants that were NEET had better outcomes than those that were White and NEET. Living in deprived areas was associated with worse outcomes. The intensity of treatment (high or low) did not moderate outcomes, but having more sessions was associated with improved outcomes for those that were NEET: odds (per one-session increase) of reliable recovery = 1.10 (1.08–1.12), deterioration = 0.94 (0.91–0.98), and attrition = 0.68 (0.66–0.71).

Conclusions

Earlier treatment, supporting those that are NEET to attend sessions, and in particular, offering them more sessions before ending treatment might be effective in improving clinical outcomes. Additional support when working with White young adults that are NEET and those in more deprived areas may also be important.

Type
Original Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Introduction

Depression and anxiety disorders are among the most burdensome diseases worldwide in terms of years of life lost to disability (James et al., Reference James, Abate, Abate, Abay, Abbafati, Abbasi and Abdelalim2018; Thornicroft et al., Reference Thornicroft, Chatterji, Evans-Lacko, Gruber, Sampson, Aguilar-Gaxiola and Kessler2017). They are highly prevalent, and result in significant impairment (McManus, Bebbington, Jenkins, & Brugha, Reference McManus, Bebbington, Jenkins and Brugha2014; James et al., Reference James, Abate, Abate, Abay, Abbafati, Abbasi and Abdelalim2018). The majority of people who have depression or anxiety experience their first episode in adolescence or early adulthood (Kessler et al., Reference Kessler, Berglund, Demler, Jin, Merikangas and Walters2005). Those with the first onset of depression or anxiety at such a stage of life are at greater risk of experiencing multiple episodes or of having long durations of illness (Buckman et al., Reference Buckman, Underwood, Clarke, Saunders, Hollon, Fearon and Pilling2018a; Curry et al., Reference Curry, Silva, Rohde, Ginsburg, Kratochvil, Simons and March2011; Rohde, Lewinsohn, Klein, Seeley, & Gau, Reference Rohde, Lewinsohn, Klein, Seeley and Gau2013), which can have a profound and long-lasting impact on their lives (Monroe, Anderson, & Harkness, Reference Monroe, Anderson and Harkness2019; Zisook et al., Reference Zisook, Lesser, Stewart, Wisniewski, Balasubramani, Fava and Rush2007). As a result, understanding the prognosis and ways in which outcomes might be improved when young adults seek treatment for depression or anxiety may be crucial to lessening the burden of these diseases at the individual and wider societal levels.

Older adults (aged 65 years old and above) appear to have better outcomes in primary care mental health services than those of working ages, particularly among those with anxiety disorders (Saunders et al., Reference Saunders, Buckman, Stott, Leibowitz, Aguirre, John and Pilling2021). Less is known about younger patients, however, it has been suggested that they might have equivalent outcomes to working-age adults following treatments in primary care (Buckman, Saunders, Stott, et al., Reference Buckman, Saunders, Stott, Arundell, O'Driscoll, Davies and Pilling2021; Community and Mental Health team, 2019). Being employed is strongly associated with a better prognosis regardless of the type of treatment given, and after accounting for a number of important clinical indicators of prognosis (Buckman, Saunders, Cohen, et al., Reference Buckman, Saunders, Cohen, Barnett, Clarke, Ambler and Pilling2021). Young people (aged 18–24 years old) are more likely to be in insecure employment than adults of other ages (Chesters et al., Reference Chesters, Smith, Cuervo, Laughland-Booÿ, Wyn, Skrbiš and Woodman2019; Fiori, Rinesi, Spizzichino, & Di Giorgio, Reference Fiori, Rinesi, Spizzichino and Di Giorgio2016). This was observed to be the case following the global recession from 2008 onwards, and has been related to ‘austerity’ policies enacted during the recession (Chesters et al., Reference Chesters, Smith, Cuervo, Laughland-Booÿ, Wyn, Skrbiš and Woodman2019; Fiori et al., Reference Fiori, Rinesi, Spizzichino and Di Giorgio2016), but the coronavirus disease-2019 (COVID-19) pandemic is likely to have greatly exacerbated difficulties gaining and maintaining employment, particularly for young adults (Power, Hughes, Cotter, & Cannon, Reference Power, Hughes, Cotter and Cannon2020; Probst, Lee, & Bazzoli, Reference Probst, Lee and Bazzoli2020). What is more, adolescents and young adults have also had their education severely disrupted during the pandemic (Onyema, Reference Onyema2020). They are therefore more likely to have lost their jobs, to have struggled to find work, and to face financial hardship relative to adults with more years of experience in employment (Chesters et al., Reference Chesters, Smith, Cuervo, Laughland-Booÿ, Wyn, Skrbiš and Woodman2019).

Young adults not in work or education are often referred to as NEETs (not in employment, education, or training) (Mawn et al., Reference Mawn, Oliver, Akhter, Bambra, Torgerson, Bridle and Stain2017; Office for National Statistics, 2017). A number of studies have found that those who are NEET are more vulnerable to mental health problems and to long-term social and physical health problems (Bäckman & Nilsson, Reference Bäckman and Nilsson2016; Gutiérrez-García, Benjet, Borges, Méndez Ríos, & Medina-Mora, Reference Gutiérrez-García, Benjet, Borges, Méndez Ríos and Medina-Mora2017; McDaid, Park, & Wahlbeck, Reference McDaid, Park and Wahlbeck2019; O'Dea et al., Reference O'Dea, Lee, McGorry, Hickie, Scott, Hermens and Glozier2016). The majority of studies on those who are NEET to-date have been cross-sectional in nature and have sampled from the general population, not those seeking or receiving treatments for their mental health. We do not know therefore, whether those who are NEET have worse outcomes in routine clinical settings than peers of the same age who are in employment, education or training, nor whether this is better explained by any difference in the severity of symptoms or other pre-treatment characteristics that differ between those who are and those that are not NEET. If those who are NEET do have worse outcomes, and these outcomes are not explained by other prognostic factors, it might indicate that they are likely to have poor long-term prognoses as well as worse short-term treatment outcomes (Buckman, et al., Reference Buckman, Underwood, Clarke, Saunders, Hollon, Fearon and Pilling2018a; Buckman, Saunders, Fearon, Leibowitz, & Pilling, 2019).

We also lack knowledge of whether there are important moderators that might lead to differential outcomes for young adults that are and are not NEET. Such knowledge may be of clinical value as it might identify targets for additional or adapted interventions to improve outcomes for those that are NEET. A large study using aggregated data from all primary care and community mental health (Improving Access to Psychological Therapies: IAPT) services in England found that there were five factors that on average, were associated with better treatment outcomes in such services (Clark et al., Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018). In that study, associations were found between: (1) conducting more sessions with each patient; (2) ensuring a higher proportion of patients had a recorded diagnosis; (3) shorter waiting times between referral and starting treatment; and (4) a lower proportion of appointments missed or cancelled, and better treatment outcomes (Clark et al., Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018). A further factor was also associated with better outcomes on average, but only applies at the service level rather than the level of the individual patient, that is, services treating a higher proportion of patients referred to them had better outcomes. When adjusting for these five factors the negative effects of social deprivation were mitigated (Clark, Reference Clark2018; Clark et al., Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018). We do not know whether such associations may apply to individuals rather than only at the aggregate level, and whether such associations would be found with those that are NEET. Therefore, there is uncertainty whether the same advice given by those authors might be relevant to services seeing those that are NEET in order to mitigate any increased risk of poor outcomes (Clark, Reference Clark2018; Clark et al., Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018).

This study, therefore, aimed to:

  1. (1) To determine whether there are differences in the treatment outcomes, engagement and attrition from psychological therapies for those who are NEET and similar-aged (18–24) peers who are employed, in education, or training, after accounting for pre-treatment differences between the groups including baseline levels of symptom severity, diagnosis, psychotropic medication use, sociodemographics (age, gender, ethnicity, long-term physical health condition status, and area-level deprivation), waiting times before having an assessment appointment and waiting time before starting treatment, and treatment factors such as the type and intensity of treatment, and the number of attended treatment sessions.

  2. (2) To determine whether there are sociodemographic or treatment-related moderators (based on gender, ethnicity, indices of multiple deprivations, and the intensity of psychological treatment) of outcomes experienced by those who are and those who are not NEET.

  3. (3) To determine whether the four factors highlighted by Clark et al. (Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018) that operate at the individual patient level are associated with better outcomes for those who are NEET.

Material and methods

This study was conducted in accordance with a pre-registered protocol and analysis plan https://osf.io/w2ndr/.

Dataset and services

Data were provided by all IAPT services that are members of the North Central and East London IAPT Service Improvement and Research Network (NCEL IAPT SIRN) (Saunders, Cape, et al., Reference Saunders, Cape, Leibowitz, Aguirre, Jena, Cirkovic and Buckman2020). These UK National Health Service (NHS) primary care and community-based mental health services deliver psychological therapies for adults with common mental health problems. They offer a range of low-intensity (LI) treatments such as guided self-help, and formal high-intensity (HI) psychological interventions such as cognitive behaviour therapy or counselling, all delivered utilising a stepped-care model in line with national guidelines and evidence-based practice [see (Clark, Reference Clark2018) for more details]. In IAPT services problem descriptors are used to identify the main presenting problem which will be the focus of treatment. These are based on diagnostic criteria in ICD-10 (World Health Organisation, 1992). The problem descriptor is not necessarily the most severe or the only diagnosis a patient may present with, but is the agreed focus of treatment. The choice of treatment is made jointly between the patient and IAPT clinician, although only those treatments recommended in clinical guidelines for the specific diagnosis are offered (Clark, Reference Clark2018). All therapists are trained to deliver treatments in line with evidence-based protocols, completing a training course commensurate with the type of treatment they will be delivering in order to work in IAPT (e.g. a diploma in LI CBT). Trainees on such courses also offer treatment in IAPT under the close supervision of trained therapists.

Participants

A retrospective cohort was formed from all patients aged under 25 years old, whose episodes of care within any of the eight participating IAPT services ended between 1st August 2008 and 1st August 2020 and who received at least two treatment sessions. There is no consensus on the age boundaries for young adulthood, here we used the minimum age of adulthood in the UK and the point at which someone may access adult mental health services (18 years old) and the maximum cut-off for young adulthood adopted by the World Health Organisation and used in many countries around the world (24 years old) (Walker-Harding, Christie, Joffe, Lau, & Neinstein, Reference Walker-Harding, Christie, Joffe, Lau and Neinstein2017). Those who were NEET were defined as participants who self-reported that they were not in any type of paid employment, full-time or part-time studies, or vocational training. Those who self-reported being in part-time or full-time employment, education or training (i.e. those who were not NEET) formed the comparison group. Patients were excluded from these analyses if they did not fit into either of these groups (e.g. if they were in voluntary employment only), if they did not report their employment status, or if they had a diagnosis for which there is no recommended evidence-based treatments in IAPT services (Clark, Reference Clark2018) such as schizophrenia, bipolar disorder, or alcohol dependency. In addition, those who did not have at least two treatment sessions in their episode of care with the IAPT services, as well as those who were not scoring above the clinical thresholds on either the measures of depression or anxiety at their initial assessment (see Table 1 and the Outcomes section below), were excluded from these analyses in line with national reporting of IAPT services (Community and Mental Health team, 2019).

Table 1. Available data and measures

Measures

The services routinely collect outcome measures of depression and anxiety symptoms at each clinical contact, as well as a measure of work and social functioning with approximately 99% coverage in pre-post treatment data on these measures (Clark, Reference Clark2018). Table 1 presents these self-report measures and additional data items that were included in the analyses.

Data analysis plan

Outcomes

Primary

The primary outcome was ‘Reliable Recovery’ defined (based on national reporting of outcomes in IAPT services) as achieving reliable change on either the PHQ-9 or GAD-7 [or another Anxiety Disorder Specific Measure (ADSM) which replaces the GAD-7 when the diagnosis is of an anxiety disorder other than generalised anxiety disorder (GAD)], or both, and moving from ‘caseness’ before treatment on either the PHQ-9 or the GAD-7 (or ADSM) to below caseness on both measures following treatment (Community and Mental Health team, 2019). The thresholds for caseness on the PHQ-9 and GAD-7 are scores of ⩾10 and ⩾8 respectively, and reliable change is defined as a reduction of ⩾6 points on the PHQ-9 or ⩾4 points on the GAD-7. See online Supplementary Table S1 for caseness and reliable change thresholds for the ADSMs.

Secondary

The following secondary outcomes were:

  • Reliable Improvement: achieving reliable change on either the PHQ-9 or GAD-7 (or other ADSM), or both (with thresholds defined in the ‘Reliable Recovery’ section above).

  • Deterioration: a reliable increase in symptoms on any symptom-based outcome measure (by the same magnitude as those used to determine reliable improvement above).

  • Engagement: defined as the proportion of treatment sessions offered to each patient that the patient attended. Sessions cancelled by the service/clinician were not counted in this outcome.

  • Attrition: defined as whether or not the reason for a patient's episode of care ending was reported to have been due to the patient dropping out of treatment prior to the planned ending, after receiving two or more treatment sessions. Patients who declined treatment or were referred on to other services were excluded from these analyses.

Confounders

Potential confounding factors were those variables outlined in Table 1, including: (1) clinical factors comprised of symptom measure scores (for depression, generalised anxiety, work and social functioning, and phobic anxiety), diagnosis (or ‘problem descriptor’), and medication status; (2) pre-treatment demographics (age, gender, ethnicity, long term condition status, and area-level deprivation based on IMD deciles or tertiles); (3) treatment-related factors including waiting times from referral to assessment, and from assessment to starting treatment, the number of LI and HI sessions attended, and the main type and intensity of treatments; (4) cohort factors including the year and month of the first attended treatment appointment; and (5) service-related factors based on the NHS Trust and services that data were collected in.

Potential moderators

These included self-identified gender, ethnicity, deprivation [tertiles of the Index of Multiple Deprivation (IMD) rank at the lower-layer super output area (LSOA) level], the main intensity of treatment (LI or HI) (see Table 1 for how defined). The four factors that can be assessed at the level of the individual patient from the Clark et al. (Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018) study were also assessed: the number of attended therapy sessions; the number of sessions cancelled or missed by the patient; whether or not a diagnosis was recorded; the number of days between referral and starting treatment, and an extension to that, whether or not patients waited less than 21 days to have their first appointment.

Data handling and data management

Missing data

Missing data on continuous variables that were not systematically missing (also known as missing by design) were imputed using multiple imputations with chained equations with the ‘ICE’ package (Royston & White, Reference Royston and White2011) in Stata (StataCorp, 2019). Imputation models included all continuous variables listed in Table 1 and were run to give 50 imputed datasets as per our pre-registered protocol, whereby only variables with less than 50% missingness would be imputed. Missing data on categorical socio-demographic variables were given a ‘missing’ code to allow these participant cases to be used in analyses (i.e. not removed due to list-wise deletion), whilst acknowledging the missing information status on the variable. The effect of the imputation was checked in sensitivity analyses run with complete data only.

Plan of analysis

To compare baseline characteristics of those who were and those who were not NEET t tests were used to explore differences in means of continuous variables between groups, and chi-square tests for categorical variables.

To investigate associations between psychological therapy outcomes and NEET status, a series of regression models were constructed with each outcome listed above (logistic models were fitted for binary outcomes and linear models for continuous outcomes). We started by modelling crude effects in univariable models then added the confounders listed above in order from 1 (clinical factors) to 5 (service-related factors), sequentially, in separate models to calculate adjusted effects. Multilevel regression models were also fitted with random effects for service-level clustering. If the associations of NEET status with the outcomes differed considerably between the multilevel and single-level models, adjusted for all confounders, multilevel modelling would have been used for the adjusted models too. This is a slight deviation from the pre-registered protocol in which we stated this would be conducted in unadjusted models. As there were no differences of note between these modelling approaches, the simpler, single-level models were retained and used for the analyses presented here.

Moderators were explored by fitting interaction terms in the fully adjusted models. In addition, the four factors highlighted by Clark et al. (Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018) were assessed in a subgroup analysis of those who were NEET only, to determine the associations between those factors and each of the outcomes listed above among those who were NEET.

Ethical approvals

NHS ethical approval was not required for this study (confirmed by the Health Research Authority July 2020, reference number 81/81). The data were provided by the IAPT services for evaluation as part of a wider service improvement project conducted in accordance with the procedures of the host institution and the NHS Trusts which operate the IAPT services (project reference: 00519-IAPT).

Results

Descriptive statistics

In this analytic sample of 20 293 adults aged under 25 years old, 4608 (22.7%) self-reported to be NEET by virtue of them not being in employment, education, or training at the point of their baseline assessment session with the services. See online Supplementary Fig. S1 for participant flow with details of exclusions. Those that were NEET were more likely to identify as men than those that were not NEET (34% compared to 26.4%), more likely to identify as of Mixed, Asian, or Other ethnicities, and less likely to identify as Black, White, or Chinese. Young adults NEET were somewhat more likely to identify as heterosexual than those that were not NEET, and were more likely to live in socially deprived neighbourhoods (see Table 2). There were no differences in the mean age between the groups. Those who were NEET were more likely to report being prescribed psychotropic medication, were more likely to have a diagnosis of depression or PTSD, and were less likely to have a diagnosis of a GAD, compared to those that were not NEET. On average, those who were NEET had higher scores across all symptom measures pre-treatment and on the work and social adjustment scale, were more likely to report having a comorbid long-term physical health condition, and waited longer between both referral and assessment and assessment and treatment, than their not NEET peers. This is commensurate with the fact that those who were NEET were more likely to have HI therapy as their main treatment intensity, and to have had fewer LI treatment sessions.

Table 2. Comparison of baseline descriptive statistics between those who were NEET and those who were not NEET

The association between NEET status and treatment outcomes

In unadjusted models, there was evidence that both reliable recovery and reliable improvement in symptoms were less likely among those who were NEET relative to those who were not NEET (Table 3). The gap in proportions of those who were and were not NEET that reliably recovered at the end of treatment grew in the months of the COVID-19 pandemic in 2020. The difference between the groups was approximately 9–10% in 2018 and 2019 but was approximately 18% in 2020. The magnitude of the effects was reduced when adjusting for baseline clinical factors, but in the fully adjusted models those who were NEET appeared to have approximately two-thirds the odds of reliable recovery and reliable improvement relative to their not NEET peers (Table 3). Those who were NEET were also more likely to experience a reliable deterioration (worsening) of symptoms pre-post treatment. In the fully adjusted models, those who were NEET had approximately 1.3 times the odds of attrition. In line with this, in the fully adjusted models, on average those who were NEET attended between three and four per cent fewer sessions of those that were booked with their therapist, compared to those that were not NEET (Table 3).

Table 3. Associations between each outcome and NEET status, crude and adjusted for increasing numbers of potential confounding factors

a Adjusted for pre-treatment PHQ-9 scores, GAD-7 scores, W&SAS items 2-5 scores, IAPT phobias scale item scores, psychotropic medication, and diagnosis.

b Additionally adjusted for gender, age, ethnicity, IMD decile, and long-term conditions.

c Additionally adjusted for the number of LI sessions, the number of HI sessions, days between referral and assessment, days between assessment and starting treatment.

d Additionally adjusted for year and month of first appointment.

e Additionally adjusted for service data came from.

Moderators of treatment outcomes

There was no evidence of moderation of outcomes by gender (e.g. for reliable recovery p = 0.800), but there was by ethnicity such that those that were NEET who identified as being of an ethnic minority group were more likely to reliably recover (p = 0.028), more likely to reliably improve (p = 0.007), and attended a higher proportion of booked appointments (p < 0.001) (Table 4). In addition, relative to those in the most deprived areas by indices of multiple deprivations, those in the least deprived one-third of areas in this dataset, who were NEET, were more likely to report reliable recovery (p = 0.012), reliable improvement (p = 0.006), and attended a higher proportion of the booked sessions (p = 0.026). There was no evidence of moderation by reporting or not reporting a comorbid long-term physical health condition (e.g. for reliable recovery p = 0.658). There was also no evidence of moderation by main intensity (LI or HI) of treatment (e.g. for reliable recovery p = 0.314). There was little evidence of moderation by the four factors identified by Clark et al. (Reference Clark, Canvin, Green, Layard, Pilling and Janecka2018) investigated here (Table 5), for example with the primary outcome: number of sessions (p = 0.332), number of missed appointments (p = 0.154), missing diagnosis (p = 0.415), and having a first treatment appointment within 6 weeks (p = 0.216). However, in the stratified analyses for every additional attended session on average, those who were NEET were more likely to reliably recover [odds ratio (OR) [95% confidence interval (CI)] = 1.10 (1.08–1.12)], reliably improve, less likely to deteriorate [OR (95% CI) = 0.94 (0.91–0.98)], and attrition was less likely, see Table 5. To further demonstrate the effect, for every three additional sessions the odds of reliable recovery for those who were NEET were considerably greater [OR (95% CI) = 1.31 (1.24–1.38)] such that attending at least nine sessions was associated with more than double the odds of reliable recovery [OR (95% CI) = 2.33(1.93–2.82)], and two-thirds the odds of deterioration [OR (95% CI) = 0.66 (0.48–0.92)], relative to attending fewer than nine sessions. Those who were NEET and missed more appointments were less likely to reliably recover OR (95% CI) = 0.95 (0.92–0.99). Those who were NEET and had a missing diagnosis code (or ‘problem descriptor’) were no more or less likely to report any of the clinical outcomes. However, attrition appeared to be less likely among those who were NEET and had a missing diagnosis code compared to those with a recorded diagnosis: OR (95% CI) = 0.68 (0.50–0.92), and those with a missing diagnostic code attended a higher proportion of booked appointments. Those who were NEET that had the first appointment within 21 days had greater odds of reliable recovery: OR (95% CI) = 1.27 (1.03–1.57).

Table 4. Associations between each outcome and NEET status moderated by baseline characteristic, in fully adjusted modelsa

a All models adjusted for PHQ-9 scores, GAD-7 scores, W&SAS items 2-5 scores, IAPT phobias scale item scores, psychotropic medication, diagnosis, gender, age, ethnicity, IMD decile, long-term conditions, number of LI sessions, number of HI sessions, days between referral and assessment, days between assessment and starting treatment, year and month of the first appointment, and service data came from. Items from this list were excluded if the same as or highly collinear with the moderating variable (e.g. gender, ethnicity, IMD Decile, and long-term conditions).

Table 5. Associations between each outcome with each potential moderator in a stratified analysis of those who were NEET only

a All models adjusted for PHQ-9 scores, GAD-7 scores, W&SAS items 2-5 scores, IAPT phobias scale item scores, psychotropic medication, diagnosis, gender, age, ethnicity, IMD decile, long-term conditions, number of LI sessions, number of HI sessions, days between referral and assessment, days between assessment and starting treatment, year and month of the first appointment, and service data came from. Items from this list were excluded if the same as or highly collinear with the moderating variable (e.g. number of attended appointments, number of HI sessions, number of LI sessions, diagnosis, and days between referral and starting treatment).

Sensitivity analyses

There were very few substantive differences when analyses were conducted using mixed-effects models for service level clustering (online Supplementary Table S2) and when conducted on observed data compared to the primary analyses with imputed data (online Supplementary Tables S3–S6). The only differences of note were that in the observed data, there appeared to be some evidence of an interaction between treatment intensity and NEET status such that those who were NEET and predominantly had HI treatment were less likely to reliably improve pre-post-treatment OR (95% CI) = 0.70 (0.56–0.87), and more likely to reliably deteriorate (1.49 (1.02–2.17)). There was also less strong evidence of an interaction between ethnicity and treatment outcomes in the observed data: OR (95% CI) for reliable recovery among BAME participants who were NEET = 1.16 (0.97–1.38).

Discussion

Young adults who were NEET seeking psychological treatment for common mental disorders in primary care had worse treatment outcomes than young adults who were not NEET. Specifically, those who were NEET had approximately two-thirds the odds of reliable recovery, about 1.4 times the odds of reliable deterioration and about a third higher odds of attrition even after adjustment for key clinical and demographic variables. Those who were NEET and of an ethnic minority had better clinical outcomes than White young adults who were NEET, and they attended a higher proportion of sessions. Those who were NEET and lived in the least deprived areas had similar outcomes to those who were not NEET. These outcomes were considerably better than those experienced by participants that were NEET and lived in the most deprived or moderately deprived areas. There was a lack of evidence that the type of treatment (HI or LI psychological therapy) moderated outcomes for those who were NEET. Importantly, the more sessions those who were NEET had, the better their chance of good treatment outcomes became. Those who were NEET had considerably greater odds of reliable recovery and reliable improvement, and lesser odds of deterioration and attrition if they attended more sessions. For example, the odds of reliable recovery were about 1.3 times higher for each additional three sessions attended, such that attending nine or more sessions was associated with more than double the odds of reliable recovery relative to attending fewer sessions. Those who were NEET and missed (cancelled or did not attend) more appointments had worse treatment outcomes, higher odds of attrition and worse engagement than those who missed fewer sessions. Waiting fewer days between referral (or registering with the services) and having a first appointment was associated with considerably better outcomes. Although, contrary to expectations, those who were NEET and had no recorded diagnosis did not appear to have worse outcomes than those with a diagnosis, and there was some evidence that they were likely to attend more sessions, and that attrition was less likely. The reasons for these effects could not be determined with the available data.

Limitations

In this clinical cohort study, there were very high rates of data completion both at baseline and post-treatment, reducing some sources of bias. By drawing on routinely collected clinical data in a group of high-volume services a large cohort of young adults was studied, providing more accurate estimates of effects than has been possible with many (smaller) studies of those that are NEET to date. However, there were a number of limitations. The cohort here had at least two treatment sessions which might have introduced selection biases as those who are NEET with better prognoses might have been more likely to attend the services than those with poorer prognoses. It was beyond the scope of the present study to investigate the reasons for not attending the services among young adults, but future research into this topic could be particularly valuable. In addition, studies might investigate any differential outcomes between those who are NEET and have or have not had prior mental health care, for example in child and adolescent mental health services, and how such care may have impacted expectations of care in adult services.

Although adjustments were made for a number of confounding factors, including those found to be associated with outcomes in similar cohorts in the past (Delgadillo, Moreea, & Lutz, Reference Delgadillo, Moreea and Lutz2016; Finegan, Firth, & Delgadillo, Reference Finegan, Firth and Delgadillo2020; Firth, Delgadillo, Kellett, & Lucock, Reference Firth, Delgadillo, Kellett and Lucock2020; Saunders et al., Reference Saunders, Buckman, Cape, Fearon, Leibowitz and Pilling2019; Saunders, Buckman, & Pilling, Reference Saunders, Buckman and Pilling2020; Saunders, Cape, et al., Reference Saunders, Cape, Leibowitz, Aguirre, Jena, Cirkovic and Buckman2020), we cannot rule out residual confounding, or confounding by variables not available here, such as information on personality difficulties or treatment expectancy (Delgadillo et al., Reference Delgadillo, Moreea and Lutz2016; Goddard, Wingrove, & Moran, Reference Goddard, Wingrove and Moran2015; Mars et al., Reference Mars, Gibson, Dunn, Gordon, Heron, Kessler and Moran2021). In addition, it has been argued that those who are NEET are less likely to live in stable housing than their not NEET peers (Robert et al., Reference Robert, Romanello, Lesieur, Kergoat, Dutertre, Ibanez and Chauvin2019), this may have contributed to their ability to attend and engage with services, data were not available on the length of housing occupancy here. Further, there might be a degree of reverse causality for example the ‘Healthy Worker Effect’ (Li & Sung, Reference Li and Sung1999) which could explain some of the disparity in clinical outcomes between those who were and were not NEET. Adjustments for long-term health conditions had minimal impact on the findings here, however it was not possible to address this fully with the data available in this study.

Eight IAPT services in the greater London area provided data as part of the NCEL network, however, the generalisability of the findings both to those outside of London and those in other clinical settings may be questioned, particularly for those findings related to social deprivation at the area-level. That notwithstanding, the disparities in deprivation across and within the areas covered by the eight services are large, with greater variability in these factors than might be found in services operating outside of London. It is also noteworthy that participants in this study most often attended fewer treatment sessions than are recommended in clinical guidelines, although this is a common phenomenon in routine clinical practice (e.g. Community and Mental Health team, 2019), it might have affected the generalisability of findings here. In addition, one of the outcomes studied here was the proportion of booked appointments attended, and we have taken this as a proxy for engagement in treatment. However, the accuracy of this as a proxy for engagement is questionable, with no information about the degree of learning occurring within the treatment sessions or of the amount of between-session work (‘homework’) conducted by patients outside of the therapy sessions. These factors are thought to be central to the outcomes achieved in many psychological therapies, particularly those that are based on cognitive behaviour therapy (Cuijpers, Karyotaki, Reijnders, & Huibers, Reference Cuijpers, Karyotaki, Reijnders and Huibers2018; Ewbank et al., Reference Ewbank, Cummins, Tablan, Bateup, Catarino, Martin and Blackwell2020; Karyotaki et al., Reference Karyotaki, Ebert, Donkin, Riper, Twisk, Burger and Cuijpers2018, Reference Karyotaki, Riper, Twisk, Hoogendoorn, Kleiboer, Mira and Cuijpers2017; Mohr et al., Reference Mohr, Ho, Duffecy, Reifler, Sokol, Burns and Siddique2012), which is the predominant modality used in IAPT services. Another outcome addressed was attrition, it might be considered circular to investigate the association between the number of attended sessions and attrition, however, given the nature of treatment in IAPT services, including variable treatment lengths and stepping up and down between high and low intensities, this was not the case here. Indeed, the maximum number of attended sessions for any participant prior to attrition was 26, and the minimum for any participant that completed therapy was two.

Implications

Young adults who are not in employment, education or training (NEET) are known to have poorer mental health than peers in employment, education or training, and to be at greater risk of social health problems (Bäckman & Nilsson, Reference Bäckman and Nilsson2016; Gutiérrez-García et al., Reference Gutiérrez-García, Benjet, Borges, Méndez Ríos and Medina-Mora2017; McDaid et al., Reference McDaid, Park and Wahlbeck2019; O'Dea et al., Reference O'Dea, Lee, McGorry, Hickie, Scott, Hermens and Glozier2016). There has recently been great concern that those who were NEET prior to the COVID-19 pandemic or those who are now NEET as a result of the pandemic are at risk of poor mental health outcomes (Fancourt, Steptoe, & Bu, Reference Fancourt, Steptoe and Bu2020; Holmes et al., Reference Holmes, O'Connor, Perry, Tracey, Wessely, Arseneault and Bullmore2020; Power et al., Reference Power, Hughes, Cotter and Cannon2020). This has led to suggestions of increasing access to psychological therapies specifically for young adults affected by the pandemic (Gunnell et al., Reference Gunnell, Appleby, Arensman, Hawton, John, Kapur and Yip2020; Kola, Reference Kola2020; Liu, Stevens, Conrad, & Hahm, Reference Liu, Stevens, Conrad and Hahm2020; Zhou, Liu, Xue, Yang, & Tang, Reference Zhou, Liu, Xue, Yang and Tang2020). The findings of the present study support such assertions of those who are NEET (approximately 59% of those who were NEET experienced a reliable improvement in symptoms in this study). However, the clinical outcomes they achieved appear to be worse than those of young adults who were employed or in education. This effect was more extreme in the months of the COVID-19 pandemic in 2020 with the difference in the rate of those who were and those who were not NEET reliably recovering growing from approximately 9–10% in 2018 and 2019, to 18% in 2020, suggesting additional adaptations may be required to optimise treatment outcomes for this population. Programs that seek to support young adults to stay in education, training, or employment, or those aimed at helping those who are NEET back into such settings, may be particularly important (Mawn et al., Reference Mawn, Oliver, Akhter, Bambra, Torgerson, Bridle and Stain2017; Moore et al., Reference Moore, Kapur, Hawton, Richards, Metcalfe and Gunnell2017; Richter & Hoffmann, Reference Richter and Hoffmann2019). Whether such programs are effective at improving the engagement and clinical outcomes of those who are NEET in primary care mental health services is a question for future studies. In addition, evaluations of programs to address digital inequalities affecting access to care for those who are NEET during the pandemic and beyond may also be informative, particularly if therapy delivered remotely is still necessary or a preferred option for some patients (Buckman, Saunders, Leibowitz, & Minton, Reference Buckman, Saunders, Leibowitz and Minton2021; Cromarty, Gallagher, & Watson, Reference Cromarty, Gallagher and Watson2020). Those who were NEET and lived in more socially deprived areas and those from White ethnic backgrounds appeared to be most at risk of poor outcomes in this study. With the data available in this study we were not able to determine why this was the case. It might therefore be helpful to consider additional research including studies focussed on intersectionality to understand the nature of these disparities and what additional support might be offered to improve engagements and outcomes for those who are NEET.

On the basis of the stratified analyses here, it would appear that starting treatment sooner, and supporting those who are NEET to attend more sessions, in particular, might be effective ways of improving their clinical outcomes. Interventions to reduce missed appointments by making changes to the organisational systems for booking appointments and sending patients reminders of their appointments appear to have been beneficial elsewhere (Aggarwal, Davies, & Sullivan, Reference Aggarwal, Davies and Sullivan2016; Behavioural Insights Team, 2010; Margham, Williams, Steadman, & Hull, Reference Margham, Williams, Steadman and Hull2021). Investigating ways to apply such learning to best meet the needs of those who are NEET could be informative. This might include qualitative interviews, outreach work and co-creation of programs with those who are NEET, thereby ensuring buy-in from those that are underserved by mental health services, in particular those in more socially deprived areas. It was notable that fewer young adults that were NEET started treatment, and fewer had predominantly LI treatments. It is often the case in primary care mental health services that LI treatments have a shorter waiting list than HI ones, and as such it would also be informative to test the effect of providing LI treatment, initially or wholly, to those who are NEET with the aim of them starting treatment sooner, and stepping up to HI treatment once available, if appropriate.

Supplementary material

The supplementary material for this article can be found at https://doi.org/10.1017/S0033291721004773.

Acknowledgements

The North and Central East London (NCEL) IAPT Service Improvement and Research Network (SIRN) includes: Andre Lynam-Smith, Catherine Simpson, Elisa Aguirre, Evi Aresti, James Gray, John Cape, Jon Wheatley, Joshua E J Buckman, Judy Leibowitz, Lila Varsani, Mina Spatha, Mirko Cirkovic, Nicole Main, Renuka Jena, Rob Saunders, Sarah Ellard, Stephen Pilling, Syed Ali Naqvi & Tania Knight. We would like to thank all clinicians and patients from NCEL IAPT services. We are grateful to the service leads for their support with the NCEL project and to the local data managers for their time and dedication.

Financial support

This work was predominantly supported by the Wellcome Trust (Grant Code 201292/Z/16/Z), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, and the Alzheimer's Society [grant code: 457 (AS-PG-18-013)]. None of these funders had any role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.

Conflict of interest

All authors declare no conflicts of interest.

References

Aggarwal, A., Davies, J., & Sullivan, R. (2016). “Nudge” and the epidemic of missed appointments. Journal of Health Organization and Management, 30(4), 558564. https://doi.org/10.1108/JHOM-04-2015-0061.CrossRefGoogle ScholarPubMed
Bäckman, O., & Nilsson, A. (2016). Long-term consequences of being not in employment, education or training as a young adult. Stability and change in three Swedish birth cohorts. European Societies, 18(2), 136157. https://doi.org/10.1080/14616696.2016.1153699.CrossRefGoogle Scholar
Behavioural Insights Team. (2010). Behavioural Insights Team Annual update 2010–11. Cabinet Office Behavioural Insights Team. 30 p. In Cabinet Office.Google Scholar
Buckman, J. E. J., Naismith, I., Saunders, R., Morrison, T., Linke, S., Leibowitz, J., … Pilling, S. (2018b). The impact of alcohol use on drop-out and psychological treatment outcomes in improving access to psychological therapies services: An audit. Behavioural and Cognitive Psychotherapy, 46(5), 513527. https://doi.org/10.1017/S1352465817000819.CrossRefGoogle ScholarPubMed
Buckman, J. E. J., Saunders, R., Fearon, P., Leibowitz, J., & Pilling, S. (2019). Attentional control as a predictor of response to psychological treatment for depression and relapse up to 1 year after treatment: A pilot cohort study. Behavioural and Cognitive Psychotherapy, 47(3), 318331. https://doi.org/10.1017/S1352465818000590.CrossRefGoogle ScholarPubMed
Buckman, J. E. J., Saunders, R., Leibowitz, J., & Minton, R. (2021). The barriers, benefits and training needs of clinicians delivering psychological therapy via video. Behavioural and Cognitive Psychotherapy, 49(6), 696720. https://doi.org/10.1017/S1352465821000187.CrossRefGoogle Scholar
Buckman, J. E. J., Underwood, A., Clarke, K., Saunders, R., Hollon, S. D., Fearon, P., … Pilling, S. (2018a). Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis. Clinical Psychology Review, 64(7), 1338. https://doi.org/10.1016/j.cpr.2018.07.005.CrossRefGoogle ScholarPubMed
Buckman, J. E. J., Saunders, R., Cohen, Z. D., Barnett, P., Clarke, K., Ambler, G., … Pilling, S. (2021). The contribution of depressive ‘disorder characteristics’ to determinations of prognosis for adults with depression: An individual patient data meta-analysis. Psychological Medicine, 51(7), 10681081. https://doi.org/10.1017/S0033291721001367.CrossRefGoogle ScholarPubMed
Buckman, J. E. J., Saunders, R., Stott, J., Arundell, L.-L., O'Driscoll, C., Davies, M. R., … Pilling, S. (2021). Role of age, gender and marital status in prognosis for adults with depression: An individual patient data meta-analysis. Epidemiology and Psychiatric Sciences, 30, e42. https://doi.org/10.1017/S2045796021000342.CrossRefGoogle ScholarPubMed
Chesters, J., Smith, J., Cuervo, H., Laughland-Booÿ, J., Wyn, J., Skrbiš, Z., & Woodman, D. (2019). Young adulthood in uncertain times: The association between sense of personal control and employment, education, personal relationships and health. Journal of Sociology, 55(2), 389408. https://doi.org/10.1177/1440783318800767.CrossRefGoogle Scholar
Clark, D. M. (2018). Realizing the mass public benefit of evidence-based psychological therapies: The IAPT program. Annual Review of Clinical Psychology, 7, 159183. https://doi.org/10.1146/annurev-clinpsy-050817-084833.CrossRefGoogle Scholar
Clark, D. M., Canvin, L., Green, J., Layard, R., Pilling, S., & Janecka, M. (2018). Transparency about the outcomes of mental health services (IAPT approach): An analysis of public data. The Lancet, 391(10121), 679686. https://doi.org/10.1016/S0140-6736(17)32133-5.CrossRefGoogle ScholarPubMed
Community and Mental Health team, N. D. (2019). Psychological Therapies, Annual report on the use of IAPT services 2018-19. Leeds.Google Scholar
Connor, K. M., Davidson, J. R. T., Churchill, L. E., Sherwood, A., Weisler, R. H., & Foa, E. (2000). Psychometric properties of the social phobia inventory (SPIN). The British Journal of Psychiatry, 176(4), 379386. https://doi.org/10.1192/bjp.176.4.379.CrossRefGoogle ScholarPubMed
Cromarty, P., Gallagher, D., & Watson, J. (2020). Remote delivery of CBT training, clinical supervision and services: In times of crisis or business as usual. Cognitive Behaviour Therapist, 13, 112. https://doi.org/10.1017/S1754470X20000343.CrossRefGoogle ScholarPubMed
Cuijpers, P., Karyotaki, E., Reijnders, M., & Huibers, M. J. H. (2018). Who benefits from psychotherapies for adult depression? A meta-analytic update of the evidence. Cognitive Behaviour Therapy, 47(2), 91106. https://doi.org/10.1080/16506073.2017.1420098.CrossRefGoogle ScholarPubMed
Curry, J., Silva, S., Rohde, P., Ginsburg, G., Kratochvil, C., Simons, A., … March, J. (2011). Recovery and recurrence following treatment for adolescent major depression. Archives of General Psychiatry, 68(3), 263270. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=psyc7&NEWS=N&AN=2011-07732-007.CrossRefGoogle ScholarPubMed
Delgadillo, J., Moreea, O., & Lutz, W. (2016). Different people respond differently to therapy: A demonstration using patient profiling and risk stratification. Behaviour Research and Therapy, 79, 1522. https://doi.org/10.1016/j.brat.2016.02.003.CrossRefGoogle ScholarPubMed
Department for Communities and Local Government. (2015). English indices of deprivation. Published 30 September 2015. Retrieved from. https://www.gov.uk/government/statistics/english-indices-of-deprivation-2015.Google Scholar
Ewbank, M. P., Cummins, R., Tablan, V., Bateup, S., Catarino, A., Martin, A. J., & Blackwell, A. D. (2020). Quantifying the association between psychotherapy content and clinical outcomes using deep learning. JAMA Psychiatry, 77(1), 3543. https://doi.org/10.1001/jamapsychiatry.2019.2664.CrossRefGoogle ScholarPubMed
Fancourt, D., Steptoe, A., & Bu, F. (2020). Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: A longitudinal observational study. The Lancet Psychiatry, 8(2), 141149. https://doi.org/10.1016/S2215-0366(20)30482-X.CrossRefGoogle Scholar
Finegan, M., Firth, N., & Delgadillo, J. (2020). Adverse impact of neighbourhood socioeconomic deprivation on psychological treatment outcomes: The role of area-level income and crime. Psychotherapy Research, 30(4), 546554. https://doi.org/10.1080/10503307.2019.1649500.CrossRefGoogle ScholarPubMed
Fiori, F., Rinesi, F., Spizzichino, D., & Di Giorgio, G. (2016). Employment insecurity and mental health during the economic recession: An analysis of the young adult labour force in Italy. Social Science and Medicine, 153, 9098. https://doi.org/10.1016/j.socscimed.2016.02.010.CrossRefGoogle Scholar
Firth, N., Delgadillo, J., Kellett, S., & Lucock, M. (2020). The influence of socio-demographic similarity and difference on adequate attendance of group psychoeducational cognitive behavioural therapy. Psychotherapy Research, 30(3), 362374. https://doi.org/10.1080/10503307.2019.1589652.CrossRefGoogle ScholarPubMed
Goddard, E., Wingrove, J., & Moran, P. (2015). The impact of comorbid personality difficulties on response to IAPT treatment for depression and anxiety. Behaviour Research and Therapy, 73, 17. https://doi.org/10.1016/j.brat.2015.07.006.CrossRefGoogle ScholarPubMed
Gunnell, D., Appleby, L., Arensman, E., Hawton, K., John, A., Kapur, N., … Yip, P. S. (2020). Suicide risk and prevention during the COVID-19 pandemic. The Lancet Psychiatry, 2019(20), 20192021. https://doi.org/10.1016/S2215-0366(20)30171-1.Google Scholar
Gutiérrez-García, R. A., Benjet, C., Borges, G., Méndez Ríos, E., & Medina-Mora, M. E. (2017). NEET Adolescents grown up: Eight-year longitudinal follow-up of education, employment and mental health from adolescence to early adulthood in Mexico City. European Child and Adolescent Psychiatry, 26(12), 14591469. https://doi.org/10.1007/s00787-017-1004-0.CrossRefGoogle ScholarPubMed
Holmes, E. A., O'Connor, R. C., Perry, V. H., Tracey, I., Wessely, S., Arseneault, L., … Bullmore, E. (2020). Multidisciplinary research priorities for the COVID-19 pandemic: A call for action for mental health science. The Lancet Psychiatry, 0366(20), 114. https://doi.org/10.1016/S2215-0366(20)30168-1.Google Scholar
IAPT National Programme Team. (2011). The IAPT data handbook 2. Department of Health, (August), 1–70. https://webarchive.nationalarchives.gov.uk/ukgwa/20160302160058/http:/www.iapt.nhs.uk/silo/files/iapt-data-handbook-v2.pdf.Google Scholar
James, S. L., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., … Abdelalim, A. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 17891858.CrossRefGoogle Scholar
Karyotaki, E., Ebert, D. D., Donkin, L., Riper, H., Twisk, J., Burger, S., … Cuijpers, P. (2018). Do guided internet-based interventions result in clinically relevant changes for patients with depression? An individual participant data meta-analysis. Clinical Psychology Review, 63(June), 8092. https://doi.org/10.1016/j.cpr.2018.06.007.CrossRefGoogle ScholarPubMed
Karyotaki, E., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., Mira, A., … Cuijpers, P. (2017). Efficacy of self-guided internet-based cognitive behavioral therapy in the treatment of depressive symptoms. JAMA Psychiatry, 74(4), 351359. https://doi.org/10.1001/jamapsychiatry.2017.0044.CrossRefGoogle ScholarPubMed
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication. Archives of General Psychiatry, 62(6), 593602. https://doi.org/10.1001/archpsyc.62.6.593.CrossRefGoogle ScholarPubMed
Kola, L. (2020). Global mental health and COVID-19. The Lancet Psychiatry, 7(8), 655657. https://doi.org/10.1016/S2215-0366(20)30235-2.CrossRefGoogle ScholarPubMed
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16, 606613.CrossRefGoogle ScholarPubMed
Li, C. Y., & Sung, F. (1999). A review of the healthy worker effect in occupational epidemiology. Occupational Medicine, 49(4), 225229.CrossRefGoogle ScholarPubMed
Liu, C. H., Stevens, C., Conrad, R. C., & Hahm, H. C. (2020). Evidence for elevated psychiatric distress, poor sleep, and quality of life concerns during the COVID-19 pandemic among U.S. young adults with suspected and reported psychiatric diagnoses. Psychiatry Research, 292(July), 113345. https://doi.org/10.1016/j.psychres.2020.113345.CrossRefGoogle ScholarPubMed
Margham, T., Williams, C., Steadman, J., & Hull, S. (2021). Reducing missed appointments in general practice: Evaluation of a quality improvement programme in east London. The British Journal of General Practice: The Journal of the Royal College of General Practitioners, 71(702), e31e38. https://doi.org/10.3399/bjgp20X713909.CrossRefGoogle ScholarPubMed
Mars, B., Gibson, J., Dunn, B. D., Gordon, C., Heron, J., Kessler, D., … Moran, P. (2021). Personality difficulties and response to community-based psychological treatment for anxiety and depression. Journal of Affective Disorders, 279, 266273. https://doi.org/10.1016/j.jad.2020.09.115.CrossRefGoogle ScholarPubMed
Mawn, L., Oliver, E. J., Akhter, N., Bambra, C. L., Torgerson, C., Bridle, C., & Stain, H. J. (2017). Are we failing young people not in employment, education or training (NEETs)? A systematic review and meta-analysis of re-engagement interventions. Systematic Reviews, 6(1), 16. https://doi.org/10.1186/s13643-016-0394-2.CrossRefGoogle ScholarPubMed
McDaid, D., Park, A. La, & Wahlbeck, K. (2019). The economic case for the prevention of mental illness. Annual Review of Public Health, 40, 373389. https://doi.org/10.1146/annurev-publhealth-040617-013629.CrossRefGoogle ScholarPubMed
McManus, S., Bebbington, P., Jenkins, R., & Brugha, T. (2014). Adult psychiatric morbidity survey: Survey of mental health and wellbeing, England, 2014. Leeds: NHS Digital. Retrieved from https://digital.nhs.uk/data-and-information/publications/statistical/adult-psychiatric-morbiditysurvey/adult-psychiatric-morbidity-survey-survey-of-mental-health-and-wellbeing-england-2014.Google Scholar
Mohr, D. C., Ho, J., Duffecy, J., Reifler, D., Sokol, L., Burns, M. N., … Siddique, J. (2012). Effect of telephone-administered vs face-to-face cognitive behavioral therapy on adherence to therapy and depression outcomes among primary care patients. JAMA, 307(21), 22782285. https://doi.org/10.1001/jama.2012.5588.CrossRefGoogle ScholarPubMed
Monroe, S. M., Anderson, S. F., & Harkness, K. L. (2019). Life stress and major depression: The mysteries of recurrences. Psychological Review, 126(6), 791816. https://doi.org/10.1037/rev0000157.CrossRefGoogle ScholarPubMed
Moore, T. H. M., Kapur, N., Hawton, K., Richards, A., Metcalfe, C., & Gunnell, D. (2017). Interventions to reduce the impact of unemployment and economic hardship on mental health in the general population: A systematic review. Psychological Medicine, 47(6), 10621084. https://doi.org/10.1017/S0033291716002944.CrossRefGoogle ScholarPubMed
Mundt, J. C., Marks, I. M., Shear, M. K., & Greist, J. M. (2002). The work and social adjustment scale: A simple measure of impairment in functioning. British Journal of Psychiatry, 180(5), 461464. https://doi.org/10.1192/bjp.180.5.461.CrossRefGoogle Scholar
O'Dea, B., Lee, R. S. C., McGorry, P. D., Hickie, I. B., Scott, J., Hermens, D. F., … Glozier, N. (2016). A prospective cohort study of depression course, functional disability, and NEET status in help-seeking young adults. Social Psychiatry and Psychiatric Epidemiology, 51(10), 13951404. https://doi.org/10.1007/s00127-016-1272-x.CrossRefGoogle ScholarPubMed
Office for National Statistics. (2017). Young people not in education, employment or training (NEET), UK - Office for National Statistics. Statistical Bulletin.Google Scholar
Onyema, E. M. (2020). Impact of coronavirus pandemic on education. Journal of Education and Practice, 11(13), 108121. https://doi.org/10.7176/jep/11-13-12.Google Scholar
Power, E., Hughes, S., Cotter, D., & Cannon, M. (2020). Youth mental health in the time of COVID-19. Irish Journal of Psychological Medicine, 37(4), 301305. https://doi.org/10.1017/ipm.2020.84.CrossRefGoogle ScholarPubMed
Probst, T. M., Lee, H. J., & Bazzoli, A. (2020). Economic stressors and the enactment of CDCRecommended COVID-19 prevention behaviors: The impact of state-level context. Journal of Applied Psychology, 105(12), 13971407. https://doi.org/10.1037/apl0000797.CrossRefGoogle ScholarPubMed
Richter, D., & Hoffmann, H. (2019). Effectiveness of supported employment in non-trial routine implementation: Systematic review and meta-analysis. Social Psychiatry and Psychiatric Epidemiology, 54(5), 525531. https://doi.org/10.1007/s00127-018-1577-z.CrossRefGoogle ScholarPubMed
Robert, S., Romanello, L., Lesieur, S., Kergoat, V., Dutertre, J., Ibanez, G., & Chauvin, P. (2019). Effects of a systematically offered social and preventive medicine consultation on training and health attitudes of young people not in employment, education or training (NEETs): An interventional study in France. PLOS ONE, 14(4), e0216226. https://doi.org/10.1371/journal.pone.0216226.CrossRefGoogle ScholarPubMed
Rohde, P., Lewinsohn, P. M., Klein, D. N., Seeley, J. R., & Gau, J. M. (2013). Key characteristics of major depressive disorder occurring in childhood, adolescence, emerging adulthood, and adulthood. Clinical Psychological Science, 1(1), 4153. https://doi.org/10.1177/2167702612457599.CrossRefGoogle ScholarPubMed
Royston, P., & White, I. R. (2011). Multiple imputation by chained equations (MICE): Implementation in stata. Journal of Statistical Software, 45(4), 120. https://doi.org/10.1002/mpr.329.Multiple.CrossRefGoogle Scholar
Saunders, R., Buckman, J. E. J., Cape, J., Fearon, P., Leibowitz, J., & Pilling, S. (2019). Trajectories of depression and anxiety symptom change during psychological therapy. Journal of Affective Disorders, 249, 327335. https://doi.org/10.1016/j.jad.2019.02.043.CrossRefGoogle ScholarPubMed
Saunders, R., Buckman, J. E. J., & Pilling, S. (2020a). Latent variable mixture modelling and individual treatment prediction. Behaviour Research and Therapy, 124(October 2019), 103505. https://doi.org/10.1016/j.brat.2019.103505.CrossRefGoogle ScholarPubMed
Saunders, R., Buckman, J. E. J., Stott, J., Leibowitz, J., Aguirre, E., John, A., … Pilling, S. (2021). Older adults respond better to psychological therapy than working-age adults: Evidence from a large sample of mental health service attendees. Journal of Affective Disorders, 294, 8593. https://doi.org/10.1016/j.jad.2021.06.084.CrossRefGoogle ScholarPubMed
Saunders, R., Cape, J., Leibowitz, J., Aguirre, E., Jena, R., Cirkovic, M., … Buckman, J. E. J. (2020). Improvement in IAPT outcomes over time: Are they driven by changes in clinical practice? The Cognitive Behaviour Therapist, 13, 115. https://doi.org/10.1017/s1754470×20000173.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder. Archives of Internal Medicine, 166(10), 1092. https://doi.org/10.1001/archinte.166.10.1092.CrossRefGoogle ScholarPubMed
StataCorp. (2019). Stata Statistical Software: Release 16. Stata Statistical Software. https://doi.org/10.2307/2234838.CrossRefGoogle Scholar
Thornicroft, G., Chatterji, S., Evans-Lacko, S., Gruber, M., Sampson, N., Aguilar-Gaxiola, S., … Kessler, R. C. (2017). Undertreatment of people with major depressive disorder in 21 countries. British Journal of Psychiatry, 210(2), 119124. https://doi.org/10.1192/bjp.bp.116.188078.CrossRefGoogle ScholarPubMed
Walker-Harding, L. R., Christie, D., Joffe, A., Lau, J. S., & Neinstein, L. (2017). Young adult health and well-being: A position statement of the society for adolescent health and medicine. Journal of Adolescent Health, 60(6), 758759. https://doi.org/10.1016/j.jadohealth.2017.03.021.Google Scholar
World Health Organization. (1992). The ICD-10 classification of mental and behavioural disorders: Diagnostic criteria for research. Geneva: World Health Organization.Google Scholar
Zhou, J., Liu, L., Xue, P., Yang, X., & Tang, X. (2020). Mental health response to the COVID-19 outbreak in China. American Journal of Psychiatry, 177(7), 574575. https://doi.org/10.1176/appi.ajp.2020.20030304.CrossRefGoogle Scholar
Zisook, S., Lesser, I., Stewart, J. W., Wisniewski, S. R., Balasubramani, G. K., Fava, M., … Rush, A. J. (2007). Effect of age at onset on the course of major depressive disorder. American Journal of Psychiatry, 164(10), 15391546. https://doi.org/10.1176/appi.ajp.2007.06101757.CrossRefGoogle ScholarPubMed
Figure 0

Table 1. Available data and measures

Figure 1

Table 2. Comparison of baseline descriptive statistics between those who were NEET and those who were not NEET

Figure 2

Table 3. Associations between each outcome and NEET status, crude and adjusted for increasing numbers of potential confounding factors

Figure 3

Table 4. Associations between each outcome and NEET status moderated by baseline characteristic, in fully adjusted modelsa

Figure 4

Table 5. Associations between each outcome with each potential moderator in a stratified analysis of those who were NEET only

Supplementary material: File

Buckman et al. supplementary material

Buckman et al. supplementary material 1

Download Buckman et al. supplementary material(File)
File 19.8 KB
Supplementary material: File

Buckman et al. supplementary material

Buckman et al. supplementary material 2

Download Buckman et al. supplementary material(File)
File 32.6 KB