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The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment

Published online by Cambridge University Press:  22 October 2020

Romain Colle ,
Khalil El Asmar ,
Céline Verstuyft ,
Pierre-Marie Lledo ,
Françoise Lazarini ,
Kenneth Chappell ,
Eric Deflesselle ,
Abd El Kader Ait Tayeb ,
Bruno Falissard  and
Emmanuelle Duron
...Show all authors
Romain Colle*
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Khalil El Asmar
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France
Céline Verstuyft
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Pierre-Marie Lledo
Affiliation:
Unité Perception et Mémoire, Institut Pasteur, CNRS UMR3571, Paris, F-75015, France
Françoise Lazarini
Affiliation:
Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Kenneth Chappell
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France
Eric Deflesselle
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France
Abd El Kader Ait Tayeb
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Bruno Falissard
Affiliation:
Département de Biostatistiques, Université Paris-Sud, Hôpital Paul Brousse, Assistance Publique Hôpitaux de Paris, Villejuif 94400, France
Emmanuelle Duron
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France
Samuel Rotenberg
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Jean-Francois Costemale-Lacoste
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France
Denis J. David
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Univ. Paris-Sud, Fac. Pharmacie, Inserm, Université Paris-Saclay, Chatenay Malabry 92290, France
Florence Gressier
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Alain M. Gardier
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Univ. Paris-Sud, Fac. Pharmacie, Inserm, Université Paris-Saclay, Chatenay Malabry 92290, France
Thomas Hummel
Affiliation:
Department of Otorhinolaryngology, Smell and Taste Clinic, Dresden, TU, Germany
Laurent Becquemont
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Centre de recherche clinique, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
Emmanuelle Corruble
Affiliation:
Equipe Moods, INSERM UMR-1178, CESP, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin Bicêtre, F-94276, France Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France
*
Author for correspondence: Romain Colle, E-mail: romaincolle@hotmail.com
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Abstract

Background

It is unclear whether olfactory deficits improve after remission in depressed patients. Therefore, we aimed to assess in drug-free patients the olfactory performance of patients with major depressive episodes (MDE) and its change after antidepressant treatment.

Methods

In the DEP-ARREST-CLIN study, 69 drug-free patients with a current MDE in the context of major depressive disorder (MDD) were assessed for their olfactory performances and depression severity, before and after 1 (M1) and 3 (M3) months of venlafaxine antidepressant treatment. They were compared to 32 age- and sex-matched healthy controls (HCs). Olfaction was assessed with a psychophysical test, the Sniffin’ Sticks test (Threshold: T score; Discrimination: D score; Identification: I score; total score: T + D + I = TDI score) and Pleasantness (pleasantness score: p score; neutral score: N score; unpleasantness score: U score).

Results

As compared to HCs, depressed patients had lower TDI olfactory scores [mean (s.d.) 30.0(4.5) v. 33.3(4.2), p < 0.001], T scores [5.6(2.6) v. 7.4(2.6), p < 0.01], p scores [7.5(3.0) v. 9.8(2.8), p < 0.001)] and higher N scores [3.5(2.6) v. 2.1(1.8), p < 0.01]. T, p and N scores at baseline were independent from depression and anhedonia severity. After venlafaxine treatment, significant increases of T scores [M1: 7.0(2.6) and M3: 6.8(3.1), p < 0.01] and p scores [M1: 8.1(3.0) and M3: 8.4(3.3), p < 0.05] were evidenced, in remitters only (T: p < 0.01; P: p < 0.01). Olfaction improvement was mediated by depression improvement.

Conclusions

The olfactory signature of MDE is restored after venlafaxine treatment. This olfaction improvement is mediated by depression improvement.

Keywords

Antidepressantsmajor depressionmajor depressive disorderolfactionolfactory pleasantnessolfactory sensitivityolfactory thresholdremission
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 11 , August 2022 , pp. 2062 - 2070
Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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