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Memory and strategic processing in first-degree relatives of obsessive compulsive patients

Published online by Cambridge University Press:  10 March 2010

C. Segalàs ,
P. Alonso ,
E. Real ,
A. Garcia ,
A. Miñambres ,
J. Labad ,
A. Pertusa ,
B. Bueno ,
S. Jiménez-Murcia  and
J. M. Menchón
C. Segalàs*
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
P. Alonso
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain
E. Real
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain
A. Garcia
Affiliation:
Department of Mental Health, Centres Assistencials Dr. Emili Mira i López, Av. Santa Coloma de Gramenet, Barcelona, Spain
A. Miñambres
Affiliation:
Hospital Sant Joan de Déu – Serveis de Salut Mental, Sant Boi de Llobregat, Barcelona, Spain
J. Labad
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain
A. Pertusa
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain
B. Bueno
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain
S. Jiménez-Murcia
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBEROBN (Ciber Fisiopatologia Obesidad y Nutrición), Instituto Salud Carlos III, Spain
J. M. Menchón
Affiliation:
OCD Clinical and Research Unit, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain
*
*Address for correspondence: Dr C. Segalàs, Department of Psychiatry, Hospital Universitario de Bellvitge, c/ Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Barcelona, Spain (Email: csegalas@bellvitgehospital.cat)
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Abstract

Background

The same executive dysfunctions and alterations in neuroimaging tests (both functional and structural) have been found in obsessive-compulsive patients and their first-degree relatives. These neurobiological findings are considered to be intermediate markers of the disease. The aim of our study was to assess verbal and non-verbal memory in unaffected first-degree relatives, in order to determine whether these neuropsychological functions constitute a new cognitive marker for obsessive-compulsive disorder (OCD).

Method

Recall and use of organizational strategies in verbal and non-verbal memory tasks were measured in 25 obsessive-compulsive patients, 25 unaffected first-degree relatives and 25 healthy volunteers.

Results

First-degree relatives and healthy volunteers did not show differences on most measures of verbal memory. However, during the recall and processing of non-verbal information, deficits were found in first-degree relatives and patients compared with healthy volunteers.

Conclusions

The presence of the same deficits in the execution of non-verbal memory tasks in OCD patients and unaffected first-degree relatives suggests the influence of certain genetic and/or familial factors on this cognitive function in OCD and supports the hypothesis that deficits in non-verbal memory tasks could be considered as cognitive markers of the disorder.

Keywords

Endophenotypeexecutive dysfunctionneuropsychologynon-verbal memoryobsessive-compulsive disorderorganizational strategiesverbal memory
Type
Original Articles
Information
Psychological Medicine , Volume 40 , Issue 12 , December 2010 , pp. 2001 - 2011
Copyright
Copyright © Cambridge University Press 2010

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References

Abbruzzese, M, Ferri, S, Scarone, S (1997). The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: a double dissociation experimental finding. Neuropsychologia 35, 907–912.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Press: Washington, DC.Google Scholar
Bearden, CE, Freimer, NB (2006). Endophenotypes for psychiatric disorders: ready for primetime? Trends in Genetics 22, 306–313.CrossRefGoogle ScholarPubMed
Beck, AT, Ward, CH, Mendelson, M, Mock, J, Erbaugh, J (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.CrossRefGoogle ScholarPubMed
Benedet, M, Alejandre, M (1998). Test de Aprendizaje Verbal España Complutense. TEA Ediciones: Madrid.Google Scholar
Burns, GL, Keortge, SG, Formea, GM, Sternberger, LG (1996). Revision of the Padua Inventory of obsessive compulsive disorder symptoms: distinctions between worry, obsessions, and compulsions. Behaviour Research and Therapy 34, 163–173.CrossRefGoogle ScholarPubMed
Cabrera, AR, McNally, RJ, Savage, CR (2001). Missing the forest for the trees? Deficient memory for linguistic gist in obsessive-compulsive disorder. Psychological Medicine 31, 1089–1094.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Fineberg, NA, Menzies, LA, Blackwell, AD, Bullmore, ET, Robbins, TW, Sahakian, BJ (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. American Journal of Psychiatry 164, 335–338.CrossRefGoogle ScholarPubMed
Chamberlain, SR, Menzies, L, Hampshire, A, Suckling, J, Fineberg, NA, del Campo, N, Aitken, M, Craig, K, Owen, AM, Bullmore, ET, Robbins, TW, Sahakian, BJ (2008). Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 321, 421–422.CrossRefGoogle ScholarPubMed
Christensen, KJ, Kim, SW, Dysken, MW, Hoover, KM (1992). Neuropsychological performance in obsessive-compulsive disorder. Biological Psychiatry 31, 4–18.CrossRefGoogle ScholarPubMed
Deckersbach, T, Otto, MW, Savage, CR, Baer, L, Jenike, MA (2000). The relationship between semantic organization and memory in obsessive-compulsive disorder. Psychotherapy and Psychosomatics 69, 101–107.CrossRefGoogle ScholarPubMed
Delis, D, Kramer, J, Kaplan, E, Ober, B (1987). The California Verbal Learning Test: Research Edition Adult Version. The Psychological Corporation: San Antonio.Google Scholar
Dirson, S, Bouvard, M, Cottraux, J, Martin, R (1995). Visual memory impairment in patients with obsessive-compulsive disorder: a controlled study. Psychotherapy and Psychosomatics 63, 22–31.CrossRefGoogle ScholarPubMed
Dougherty, DM, Bjork, JM, Moeller, FG, Harper, RA, Marsh, DM, Mathias, CW, Swann, AC (2003). Familial transmission of Continuous Performance Test behavior: attentional and impulsive response characteristics. Journal of General Psychology 130, 5–21.CrossRefGoogle ScholarPubMed
Faraone, SV, Seidman, LJ, Kremen, WS, Toomey, R, Pepple, JR, Tsuang, MT (2000). Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biological Psychiatry 48, 120–126.CrossRefGoogle Scholar
First, M, Gibbon, M, Spitzer, R, Williams, JW (1997 a). Structured Clinical Interview for DSM-IV Axis II Personality Disorders. American Psychiatric Press: Washington, DC.Google Scholar
First, M, Spitzer, R, Gibbon, M, Williams, J (1997 b). Structured Clinical Interview for DSM-IV Axis I Disorders – Clinician Version. American Psychiatric Press: Washington, DC.Google Scholar
Gallagher, B, Cartwright-Hatton, S (2008). The relationship between parenting factors and trait anxiety: Mediating role of cognitive errors and metacognition. Anxiety Disorders 22, 722–733.CrossRefGoogle ScholarPubMed
Glahn, DC, Bearden, CE, Niendam, TA, Escamilla, MA (2004). The feasibility of neuropsychological endophenotypes in the search for genes associated with bipolar affective disorder. Bipolar Disorders 6, 171–182.CrossRefGoogle ScholarPubMed
Goldberg, DP, Hillier, VF (1979). A scaled version of the General Health Questionnaire. Psychological Medicine 9, 139–145.CrossRefGoogle ScholarPubMed
Goodman, WK, Price, LH, Rasmussen, SA, Mazure, C, Fleischmann, RL, Hill, CL, Heninger, GR, Charney, DS (1989). The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Archives of General Psychiatry 46, 1006–1011.CrossRefGoogle ScholarPubMed
Gottesman, II, Gould, TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636–645.CrossRefGoogle ScholarPubMed
Grossman, M, Carvell, S, Peltzer, L, Stern, M, Hurtig, H (1993). Visual construction impairments in Parkinson's disease. Neuropsychologia 7, 536–547.CrossRefGoogle Scholar
Hernandez, MT, Sauerwein, HC, Jambaqué, I, de Guise, E, Lussier, F, Lortie, A, Dulac, O, Lassonde, M (2003). Attention, memory, and behavioral adjustment in children with frontal lobe epilepsy. Epilepsy & Behavior 4, 522–536.CrossRefGoogle ScholarPubMed
Huber, S, Glatt, S (1992). Neuroimaging Correlates of Dementia in Parkinson's Disease. Oxford University Press: New York.Google Scholar
Ibàñez, I, Olmedo, E, Peñate, W, González, M (2002). Obsesiones y compulsiones: estructura del Inventario de Padua. International Journal of Clinical and Health Psychology 2, 263–288.Google Scholar
Lezak, MD (1995). The temporal lobes and their disorders: functional organization of the posterior cortex: the behavioral geography of the brain. In Neuropsychological Assessment (ed. Lezak, M. D.), pp. 81–87. New York: Oxford University Press.Google Scholar
Massman, PJ, Delis, DC, Butters, N, Levin, BE, Salmon, DP (1990). Are all subcortical dementias alike? Verbal learning and memory in Parkinson's and Huntington's disease patients. Journal of Clinical and Experimental Neuropsychology 12, 729–744.CrossRefGoogle ScholarPubMed
Mataix-Cols, D, Rauch, SL, Manzo, PA, Jenike, MA, Baer, L (1999). Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. American Journal of Psychiatry 156, 1409–1416.CrossRefGoogle ScholarPubMed
Menzies, L, Achard, S, Chamberlain, SR, Fineberg, N, Chen, CH, del Campo, N, Sahakian, BJ, Robbins, TW, Bullmore, E (2007). Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 130, 3223–3236.CrossRefGoogle ScholarPubMed
Menzies, L, Williams, GB, Chamberlain, SR, Ooi, C, Fineberg, N, Suckling, J, Sahakian, BJ, Robbins, TW, Bullmore, ET (2008). White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. American Journal of Psychiatry 165, 1308–1315.CrossRefGoogle ScholarPubMed
Meyers, J, Meyers, K (1995). Rey Complex Figures Test and Recognition Trial: Professional Manual. Psychological Assessment Resources: Odessa.Google Scholar
Morillo, C, Belloch, A, Garcia-Soriano, G (2007). Clinical obsessions in obsessive-compulsive patients and obsession-relevant intrusive thoughts in non-clinical, depressed and anxious subjects: where are the differences? Behaviour Research and Therapy 45, 1319–1333.CrossRefGoogle ScholarPubMed
Moritz, S, Kloss, M, Jahn, H, Schick, M, Hand, I (2003). Impact of comorbid depressive symptoms on nonverbal memory and visuospatial performance in obsessive-compulsive disorder. Cognitive Neuropsychiatry 8, 261–272.CrossRefGoogle ScholarPubMed
Oldfield, RC (1971). The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97–113.CrossRefGoogle ScholarPubMed
Osterrieth, P (1944). Le test de copie d'une figure complex: contribution à l'étude de la perception et de la mémoire. (The test of copying a complex figure: a contribution to the study of perception and memory). Archives de Psycologie 30, 286–356.Google Scholar
Penades, R, Catalan, R, Andres, S, Salamero, M, Gasto, C (2005). Executive function and nonverbal memory in obsessive-compulsive disorder. Psychiatry Research 133, 81–90.CrossRefGoogle ScholarPubMed
Raven, J, Court, J (1996). Raven's Progressive Matrices. TEA Ediciones: Madrid.Google Scholar
Sanavio, E (1988). Obsessions and compulsions: the Padua Inventory. Behaviour Research and Therapy 26, 169–177.CrossRefGoogle ScholarPubMed
Savage, CR, Baer, L, Keuthen, NJ, Brown, HD, Rauch, SL, Jenike, MA (1999). Organizational strategies mediate nonverbal memory impairment in obsessive-compulsive disorder. Biological Psychiatry 45, 905–916.CrossRefGoogle ScholarPubMed
Savage, CR, Deckersbach, T, Wilhelm, S, Rauch, SL, Baer, L, Reid, T, Jenike, MA (2000). Strategic processing and episodic memory impairment in obsessive compulsive disorder. Neuropsychology 14, 141–151.CrossRefGoogle ScholarPubMed
Savage, CR, Keuthen, NJ, Jenike, MA, Brown, HD, Baer, L, Kendrick, AD, Miguel, EC, Rauch, SL, Albert, MS (1996). Recall and recognition memory in obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences 8, 99–103.Google ScholarPubMed
Savage, CR, Rauch, SL (2000). Cognitive deficits in obsessive-compulsive disorder. American Journal of Psychiatry 157, 1182–1183.CrossRefGoogle ScholarPubMed
Segalas, C, Alonso, P, Labad, J, Jaurrieta, N, Real, E, Real, E, Jiménez, S, Menchón, JM, Vallejo, J (2008). Verbal and nonverbal memory processing in patients with obsessive-compulsive disorder: its relationship to clinical variables. Neuropsychology 22, 262–272.CrossRefGoogle ScholarPubMed
Spielberger, CD, Gorsuch, RL, Lushene, RE (1982). Cuestionario de Ansiedad Estado-Rasgo (Spanish adaptation from the manual for the State-Trait Anxiety Inventory). TEA Ediciones: Madrid.Google Scholar
Spitzer, RL, Williams, JB, First, M, Kendler, K (1989). A proposal for DSM-IV: solving the ‘organic/nonorganic’ problem. Journal of Neuropsychiatry and Clinical Neurosciences 1, 126–127.Google ScholarPubMed
Starkstein, SE, Brandt, J, Folstein, S, Strauss, M, Berthier, ML, Pearlson, GD, Wong, D, McDonnell, A, Folstein, M (1988). Neuropsychological and neuroradiological correlates in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry 51, 1259–1263.CrossRefGoogle ScholarPubMed
Wechsler, D (1981). Escala de Inteligencia de Wechsler para Adultos-III. TEA Ediciones: Madrid.Google Scholar
Weintraub, D, Moberg, PJ, Culbertson, WC, Duda, JE, Stern, MB (2004). Evidence for impaired encoding and retrieval memory profiles in Parkinson disease. Cognitive and Behavioral Neurology 17, 195–200.Google ScholarPubMed