Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-19T21:22:52.699Z Has data issue: false hasContentIssue false
  • English
  • Français

Folate and amine metabolites in senile dementia: a combined trial and biochemical study

Published online by Cambridge University Press:  09 July 2009

David M. Shaw ,
David A. Macsweeney ,
Anthony L. Johnson ,
Ruth O'Keeffe ,
D. Naidoo ,
D. M. Macleods ,
Sudha Jog ,
John M. Preece  and
J. M. Crowley
David M. Shaw
Affiliation:
M.R.C. Neuropsychiatry Unit, Carshalton, and West Park Hospital, Epsom, Surrey
David A. Macsweeney
Affiliation:
M.R.C. Neuropsychiatry Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Anthony L. Johnson
Affiliation:
M.R.C. Neuropsychiatry Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Ruth O'Keeffe
Affiliation:
M.R.C. Neuropsychiatry Unit, Carshalton, and West Park Hospital, Epsom, Surrey
D. Naidoo
Affiliation:
Cane Hill Hospital, Coulsdon, Surrey
D. M. Macleods
Affiliation:
Cane Hill Hospital, Coulsdon, Surrey
Sudha Jog
Affiliation:
Cane Hill Hospital, Coulsdon, Surrey
John M. Preece
Affiliation:
Area Laboratory, West Park Hospital, Epsom, Surrey
J. M. Crowley
Affiliation:
Area Laboratory, West Park Hospital, Epsom, Surrey
Get access Rights & Permissions [Opens in a new window]

Synopsis

Folate (RBC, serum, CSF) and B12 (serum and CSF) and 5-HIAA and HVA (CSF) concentrations were measured in patients with senile dementia. Those with RBC folate < 130 ng/ml. were given folate/B12 in a double-blind crossover trial. (1) Amine metabolites and folate were unrelated. (2) CSF folate levels rose significantly but slowly on ward diet only independently of the period of intensive replacement. (3) There was no clinical improvement over the 24 weeks of observation but in view of the biochemical findings the period of study may have been too short.

Type
Research Article
Information
Psychological Medicine , Volume 1 , Issue 2 , February 1971 , pp. 166 - 171
Copyright
Copyright © Cambridge University Press 1971

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anden, N -E., Roos, B -E., and Werdinius, B. (1963). On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorimetric method. Life Sciences, 2, 448–458.CrossRefGoogle Scholar
Ashcroft, G. W., Crawford, T. B. B., Dow, R. C., and Guldberg, H. C. (1968). Homovanillic acid, 3,4-dihydroxy-phenylacetic acid and 5-hydroxyindol-3-ylacetic acid in serial samples of cerebrospinal fluid from the lateral ventricle of the dog. British Journal of Pharmacology and Chemotherapy, 33, 441–456.CrossRefGoogle Scholar
Baker, H., Herbert, V., Frank, O., Pasher, I., Hutner, S. H., Wasserman, L. R., and Sobotka, H. (1959). A micro-biologic method for detecting folic acid deficiency in man. Clinical Chemistry, 5, 275–280.CrossRefGoogle Scholar
Blessed, G., Tomlinson, B. E., and Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797–811.CrossRefGoogle ScholarPubMed
Carney, M. W. P. (1967). Serum folate values in 423 psychiatric patients. British Medical Journal, 4, 512–516.CrossRefGoogle ScholarPubMed
Chanarin, I. (1969). The Megaloblastic Anaemias. Blackwell Scientific Publications: Oxford.Google Scholar
Gal, E. M., Armstrong, J. C., and Ginsberg, B. (1966). The nature of in vitro hydroxylation of L-tryptophan by brain tissue. Journal of Neurochemistry, 13, 643–654.CrossRefGoogle ScholarPubMed
Gordon, A. E. (1970). Personal communication.Google Scholar
Gottfries, C. G., Gottfries, I., and Roos, B-E. (1969). Homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid of patients with senile dementia, pre-senile dementia and parkinsonism. Journal of Neurochemistry, 16, 1341–1345.CrossRefGoogle Scholar
Grahame-Smith, D. G. (1967). The biosynthesis of 5-hydroxytryptamine in brain. Biochemical Journal, 105, 351–360.CrossRefGoogle ScholarPubMed
Hoffbrand, A. V., Newcombe, B. F. A., and Mollin, D. L. (1966). Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. Journal of Clinical Pathology, 19, 17–28.CrossRefGoogle ScholarPubMed
Hurdle, A. D. F., and Picton Williams, T. C. (1966). Folic-acid deficiency in elderly patients admitted to hospital. British Medical Journal, 2, 202–205.CrossRefGoogle ScholarPubMed
Kaufman, S., and Friedman, S. (1965). Dopamine-β hydroxylase. Pharmacological Reviews, 17, 71–100.Google ScholarPubMed
Kendrick, D. C. (1967). A cross-validation study of the use of the SLT and DCT in screening for diffuse brain pathology in elderly subjects. British Journal of Medical Psychology, 40, 173–178.CrossRefGoogle ScholarPubMed
Maickel, R. P., Cox, R. H. Jr., Saillant, J., and Miller, F. P. (1968). A method for the determination of serotonin and norepinephrine in discrete areas of rat brain. International Journal of Neuropharmacology, 7, 275–281.CrossRefGoogle ScholarPubMed
Portig, P. J., Sharman, D. F., and Vogt, M. (1968). Release by tubocurarine of dopamine and homovanillic acid from the superfused caudate nucleus. Journal of Physiology, 194, 565–572.CrossRefGoogle ScholarPubMed
Read, A. E., Gough, K. R., Pardoe, J. L., and Nicholas, A. (1965). Nutritional studies on the entrants to an old people's home, with particular reference to folic-acid deficiency. British Medical Journal, 2, 843–848.CrossRefGoogle Scholar
Reynolds, E. H. (1970). latrogenic disorders in epilepsy. In Modern Trends in Neurology—5, pp. 271–286. Edited by Williams, D.. Butterworths: London.Google Scholar
Shulman, R. (1967). A survey of vitamin B12 deficiency in an elderly psychiatric population. British Journal of Psychiatry, 113, 241–251.CrossRefGoogle Scholar