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Effects of maintenance amitriptyline and psychotherapy on symptoms of depression

Published online by Cambridge University Press:  09 July 2009

E. S. Paykel ,
A. Dimascio ,
D. Haskell  and
B. A. Prusoff
E. S. Paykel
Affiliation:
St. George's Hospital, London, Boston State Hospital, Boston, Mass., Yale University School of Medicine, New Haven, Conn., U. S. A.
A. Dimascio
Affiliation:
St. George's Hospital, London, Boston State Hospital, Boston, Mass., Yale University School of Medicine, New Haven, Conn., U. S. A.
D. Haskell
Affiliation:
St. George's Hospital, London, Boston State Hospital, Boston, Mass., Yale University School of Medicine, New Haven, Conn., U. S. A.
B. A. Prusoff
Affiliation:
St. George's Hospital, London, Boston State Hospital, Boston, Mass., Yale University School of Medicine, New Haven, Conn., U. S. A.
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Synopsis

Depressives responding to initial treatment were maintained on amitriptyline for eight months, withdrawn double-blind to placebo after two months, or withdrawn overtly onto no medication. In each group half the patients received weekly psychotherapy and half were seen, once monthly. Effects on symptom ratings were examined. Maintenance amitriptyline gave a significant advantage over early withdrawal in preventing symptom recrudescence. There were no differences between double-blind or overt withdrawal. There were no interactions between drug withdrawal and psychotherapy. Psychotherapy produced no significant advantages over low contact on symptoms, although it did improve social adjustment ratings reported elsewhere.

Type
Research Article
Information
Psychological Medicine , Volume 5 , Issue 1 , February 1975 , pp. 67 - 77
Copyright
Copyright © Cambridge University Press 1975

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References

REFERENCES

DiMascio, A., Haskell, D. and Prusoff, B. A. (In press.) Side effects of amitriptyline in the treatment of outpatient neurotic depressives. Journal of Nervous and Mental Disease.Google Scholar
Fox, R. E., Strupp, H. H., and Lessler, K. (1968). The psychotherapy experience in retrospect: problems and potentials of an approach. In An Evaluation of the Results of the Psychotherapies, pp. 38–48. Edited by Lesse, S.. Thomas: Springfield, Ill.Google Scholar
Frank, J. D. (1961). Persuasion and Healing. Johns Hopkins Press: Baltimore.Google Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Hogarty, G. E., Goldberg, S. C., and The Collaborative Study Group, Baltimore. (1973). Drug and sociotherapy in the aftercare of schizophrenic patients. One-year relapse rates. Archives of General Psychiatry, 28, 54–64.CrossRefGoogle ScholarPubMed
Imlah, N. W., Fahy, P. T. P., and Harrington, J. A. (1964). A comparison of two antidepressant drugs. Psychopharmacologia, 6, 472–474.CrossRefGoogle ScholarPubMed
Kay, D. W. K., Fahy, T., and Garside, R. F. (1970). A seven-month double-blind trial of amitriptyline and diazepam in ECT-treated depressed patients. British Journal of Psychiatry, 117, 667–671.CrossRefGoogle ScholarPubMed
Klerman, G. L. (1963). Assessing the influence of the hospital milieu upon the effectiveness of psychiatric drug therapy: problems of conceptualization and of research methodology. Journal of Nervous and Mental Disease, 137, 143–154.CrossRefGoogle ScholarPubMed
Klerman, G. L., DiMascio, A., Weissman, M., Prusoff, B. A., and Paykel, E. S. (1974). Treatment of depression by drugs and psychotherapy. American Journal of Psychiatry, 131, 186–191.CrossRefGoogle ScholarPubMed
Kramer, J. C., Klein, D. F., and Fink, M. (1961). Withdrawal symptoms following discontinuation of imipramine therapy. American Journal of Psychiatry, 118, 549–550.CrossRefGoogle Scholar
Mindham, R. H. S., Howland, C., and Shepherd, M. (1973). An evaluation of continuation therapy with tricyclic antidepressant in depressive illness. Psychological Medicine, 3, 5–17.CrossRefGoogle ScholarPubMed
Overall, J. E., and Gorham, D. R. (1962). The brief psychiatric rating scale. Psychological Reports, 10, 799–812.CrossRefGoogle Scholar
Parloff, M. B., Kelman, H. C., and Frank, J. D. (1954). Comfort, effectiveness, and self-awareness as criteria of improvement in psychotherapy. American Journal of Psychiatry, 111, 343–352.CrossRefGoogle ScholarPubMed
Paykel, E. S., Klerman, G. L., and Prusoff, B. A. (1970). Treatment setting and clinical depression. Archives of General Psychiatry, 22, 11–21.CrossRefGoogle ScholarPubMed
Prien, R. F., Klett, C. J., and Caffey, E. M. Jr. (1973). Lithium carbonate and imipramine in prevention of affective episodes. Archives of General Psychiatry, 29, 420–425.CrossRefGoogle ScholarPubMed
Prusoff, B. A., Klerman, G. L., and Paykel, E. E. (1972). Concordance between clinical assessments and patients' self-report in depression. Archives of General Psychiatry, 26, 546–552.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J., Reatig, N., and McKeon, J. J. (1969). Replication of factors of psychopathology in interview, ward behavior and self-report ratings of hospitalized depressives. Journal of Nervous and Mental Disease, 148, 87–98.CrossRefGoogle ScholarPubMed
Raskin, A., Schulterbrandt, J., Reatig, N., and McKeon, J. J. (1970). Differential response to chlorpromazine, imipramine, and placebo. A study of subgroups of hospitalized depressed patients. Archives of General Psychiatry, 23, 164–173.CrossRefGoogle ScholarPubMed
Seager, C. P., and Bird, R. L. (1962). Imipramine with electrical treatment in depression—a controlled trial. Journal of Mental Science, 108, 704–707.CrossRefGoogle ScholarPubMed
Uhlenhuth, E. H., Lipman, R. S., and Covi, L. (1969). Combined pharmacotherapy and psychotherapy. Controlled studies. Journal of Nervous and Mental Disease, 148, 52–64.CrossRefGoogle Scholar
Weissman, M. M., Klerman, G. L., Paykel, E. S., Prusoff, B. A., and Hanson, B. (1974.) Treatment effects on the social adjustment of depressed patients. Archives of General Psychiatry, 30, 771–778.CrossRefGoogle ScholarPubMed
Wheatley, D. (1972). Drowsiness and antidepressant drugs in mild depressive illness. British Journal of Psychiatry, 120, 517–519.CrossRefGoogle ScholarPubMed
Willcox, D. R. C., Gillan, R., and Hare, E. H. (1965). Do psychiatric out-patients take their drugs? British Medical Journal, 2, 790–792.CrossRefGoogle Scholar
World Health Orgainization. (1967 and 1969). International Classification of Diseases. Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death. 8th Revision. 1965. 2 vols. W.H.O. Geneva.Google Scholar