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Effect of selective serotonin reuptake inhibitor on prefrontal-striatal connectivity is dependent on the level of TNF-α in patients with major depressive disorder

Published online by Cambridge University Press:  06 December 2018

Kai Liu ,
Xiaohua Zhao ,
Xiaobing Lu ,
Xiaoxia Zhu ,
Hui Chen ,
Mengmeng Wang ,
Weixin Yan ,
Linlin Jing ,
Yanjia Deng  and
Lin Yu
...Show all authors
Kai Liu
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China
Xiaohua Zhao
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Xiaobing Lu
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Xiaoxia Zhu
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Hui Chen
Affiliation:
Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China
Mengmeng Wang
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Weixin Yan
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
Linlin Jing
Affiliation:
TCM Integrated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China
Yanjia Deng
Affiliation:
Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China
Lin Yu
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Huawang Wu
Affiliation:
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
Ge Wen*
Affiliation:
Medical Imaging Department, Nanfang Hospital, Southern Medical University, Guangzhou, China
Xuegang Sun*
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, China
Zhiping Lv*
Affiliation:
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
*
Author for correspondence: Zhiping Lv, E-mail: lzp48241@126.com and Ge Wen, E-mail: m13360022166@163.com; Xuegang Sun, E-mail: sxg_smu@126.com
Author for correspondence: Zhiping Lv, E-mail: lzp48241@126.com and Ge Wen, E-mail: m13360022166@163.com; Xuegang Sun, E-mail: sxg_smu@126.com
Author for correspondence: Zhiping Lv, E-mail: lzp48241@126.com and Ge Wen, E-mail: m13360022166@163.com; Xuegang Sun, E-mail: sxg_smu@126.com
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Abstract

Background

We hypothesize that the tumor necrosis factor-α (TNF-α) may play a role in disturbing the effect of selective serotonin reuptake inhibitor (SSRI) on the striatal connectivity in patients with major depressive disorder (MDD).

Methods

We performed a longitudinal observation by combining resting-state functional magnetic resonance imaging (rs-fMRI) and biochemical analyses to identify the abnormal striatal connectivity in MDD patients, and to evaluate the effect of TNF-α level on these abnormal connectivities during SSRI treatment. Eighty-five rs-fMRI scans were collected from 25 MDD patients and 35 healthy controls, and the scans were repeated for all the patients before and after a 6-week SSRI treatment. Whole-brain voxel-wise functional connectivity (FC) was calculated by correlating the rs-fMRI time courses between each voxel and the striatal seeds (i.e. spherical regions placed at the striatums). The level of TNF-α in serum was evaluated by Milliplex assay. Factorial analysis was performed to assess the interaction effects of ‘TNF-α × treatment’ in the regions with between-group FC difference.

Results

Compared with controls, MDD patients showed significantly higher striatal FC in the medial prefrontal cortex (MPFC) and bilateral middle/superior temporal cortices before SSRI treatment (p < 0.001, uncorrected). Moreover, a significant interaction effect of ‘TNF-α × treatment’ was found in MPFC-striatum FC in MDD patients (p = 0.002), and the significance remained after adjusted for age, gender, head motion, and episode of disease.

Conclusion

These findings provide evidence that treatment-related brain connectivity change is dependent on the TNF-α level in MDD patients, and the MPFC-striatum connectivities possibly serve as an important target in the brain.

Keywords

Major depressive disorderresting-state functional connectivityselective serotonin reuptake inhibitorstriatumtumor necrosis factor-α
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 15 , November 2019 , pp. 2608 - 2616
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

*

These authors contributed equally to this paper.

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