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The combined impact of Type D personality and depression on cardiovascular events after acute myocardial infarction

Published online by Cambridge University Press:  02 August 2021

Yini Wang ,
Xueqin Gao ,
Zhenjuan Zhao ,
Ling Li ,
Guojie Liu ,
Hui Tao ,
Xi Yu ,
Bo Yu  and
Ping Lin
Yini Wang
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Xueqin Gao
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Zhenjuan Zhao
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Ling Li*
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Guojie Liu
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Hui Tao
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Xi Yu
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Bo Yu*
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Ping Lin*
Affiliation:
Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
*
Authors for correspondence: Ping Lin, E-mail: linping_1962@163.com; Bo Yu, E-mail: yubodr@163.com
Authors for correspondence: Ping Lin, E-mail: linping_1962@163.com; Bo Yu, E-mail: yubodr@163.com
Authors for correspondence: Ping Lin, E-mail: linping_1962@163.com; Bo Yu, E-mail: yubodr@163.com
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Abstract

Background

Type D personality and depression are the independent psychological risk factors for adverse outcomes in cardiovascular patients. The aim of this study was to examine the combined effect of Type D personality and depression on clinical outcomes in patients suffering from acute myocardial infarction (AMI).

Methods

This prospective cohort study included 3568 patients diagnosed with AMI between February 2017 and September 2018. Type D personality and depression were assessed at baseline, while the major adverse cardiac event (MACE) rate (cardiac death, recurrent non-fatal myocardial infarction, revascularization, and stroke) and in-stent restenosis (ISR) rate were analyzed after a 2-year follow-up period.

Results

A total of 437 patients developed MACEs and 185 had ISR during the follow-up period. The Type D (+) depression (+) and Type D (+) depression (−) groups had a higher risk of MACE [95% confidence interval (CI) 1.74–6.07] (95% CI 1.25–2.96) and ISR (95% CI 3.09–8.28) (95% CI 1.85–6.22). Analysis of Type D and depression as continuous variables indicated that the main effect of Type D, depression and their combined effect were significantly associated with MACE and ISR. Moreover, Type D (+) depression (+) and Type D (+) depression (−) emerged as significant risk factors for MACE and ISR in males, while only Type D (+) depression (+) was associated with MACE and ISR in female patients.

Conclusions

These findings suggest that patients complicated with depression and Type D personality are at a higher risk of adverse cardiovascular outcomes. Individual assessments of Type D personality and depression, and comprehensive interventions are required.

Keywords

Acute myocardial infarctioncardiovascular eventsdepressionin-stent restenosisType D personality
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 4 , March 2023 , pp. 1379 - 1389
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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