Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-25T02:17:56.781Z Has data issue: false hasContentIssue false
  • English
  • Français

Biogenic amine-related enzymes and personality variations in normals

Published online by Cambridge University Press:  09 July 2009

D. L. Murphy ,
R. H. Belmaker ,
M. Buchsbaum ,
N. F. Martin ,
R. Ciaranello  and
R. J. Wyatt
D. L. Murphy*
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
R. H. Belmaker
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
M. Buchsbaum
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
N. F. Martin
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
R. Ciaranello
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
R. J. Wyatt
Affiliation:
Laboratory of Clinical Science, The Adult Psychiatry Branch, Laboratory of Psychopharmacology, National Institute of Mental Health, Bethesda, Maryland
*
1Address for correspondence: Dr D. L. Murphy, NIH Clinical Center, 10–3S229, Bethesda, MD 20014, USA.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Altered activities of biogenic amine-related enzymes have been reported in some studies of patients with affective disorders and chronic schizophrenia. To evaluate whether any relationship between personality variations, including non-diagnosed psychopathology, and these enzymes might occur in non-psychiatric patients, 95 young adult volunteers were studied. Higher MMPI and Zuckerman sensation-seeking scale scores were found in male, but not female, volunteers with lower platelet and plasma amine oxidase activities. Males generally exhibited negative correlations, while females had positive correlations between the psychological test scores and amine oxidase activities. In contrast to the amine oxidase results, no associations were observed between plasma dopamine β-hydroxylase activities and the personality variables.

Type
Preliminary Communication
Information
Psychological Medicine , Volume 7 , Issue 1 , February 1977 , pp. 149 - 157
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Belmaker, R. H., Murphy, D. L., Wyatt, R. J. & Loriaux, D. L. (1974). Human platelet monoamine oxidase changes during the menstrual cycle. Archives of General Psychiatry 31, 553–556.CrossRefGoogle ScholarPubMed
Buchsbaum, M., Goodwin, F. K., Murphy, D. L. & Borge, G. (1971). Average evoked responses in affective disorders. American Journal of Psychiatry 128, 19–25.Google Scholar
Dahistrom, W. G. & Prange, A. J. (1960). Characteristics of depressive and paranoid schizophrenic reactions on the Minnesota multiphasic personality inventory. Journal of Nervous and Mental Disease 131, 513–522.CrossRefGoogle Scholar
Dahlstrom, W. G. & Welsh, G. S. (1960). An MMPI Handbook: A Guide to Use in Clinical Practice and Research. University of Minnesota Press: Minneapolis.Google Scholar
Donnelly, E. F. & Murphy, D. L. (1973). Primary affective disorder: MMPI differences between unipolar and bipolar depressed subjects. Journal of Clinical Psychology 29, 303–306.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Donnelly, E. F. & Murphy, D. L. (1974). Primary affective disorder: Bender-gestalt sequence of placement as an indicator of impulse control. Perceptual and Motor Skills 38, 1079–1082.Google Scholar
Donnelly, E. F., Murphy, D. L. & Scott, W. H. (1975). Perception and cognition in patients with bipolar and unipolar depressive disorders: A study in Rorschach responding. Archives of General Psychiatry 32, 1128–1133.Google Scholar
Guthrie, G. M. (1950). Six MMPI diagnostic profile patterns. Journal of Psychology 30, 317–323.CrossRefGoogle Scholar
Lamprecht, F., Wyatt, R. J., Belmaker, R., Murphy, D. L. & Pollin, W. (1973). Plasma dopamine-beta-hydroxylase in identical twins discordant for schizophrenia. In Frontiers in Catecholamine Research (ed. Usdin, E. and Snyder, S.), pp. 1123–1126. Pergamon Press: Oxford.Google Scholar
Lanyon, R. I. (1968). A Handbook of MMPI Group Profiles. University of Minnesota Press: Minneapolis.Google Scholar
Leckman, J., Gershon, E., Nichols, A. & Murphy, D. L. (In the press). Reduced platelet MAO activity in the first degree relatives of patients with bipolar affective disorders. Archives of General Psychiatry.Google Scholar
McEwen, C. M. (1972). The soluble monoamine oxidase of human plasma and sera. Advances in Biochemical Psychopharmacology 5, 151–165.Google Scholar
Molinoff, P. B., Weinshilboum, R. & Axelrod, J. (1971). A sensitive enzymatic assay for dopamine β-hydroxylases. Journal of Pharmacology and Experimental Therapeutics 178, 425–432.Google Scholar
Murphy, D. L. (1973). Technical strategies for the study of catecholamines in man. In Frontiers in Catecholamine Research (ed. Usdin, E. and Snyder, S.), pp. 1077–1082. Pergamon Press: Oxford.Google Scholar
Murphy, D. L. & Donnelly, C. H. (1974). Monoamine oxidase in man: enzyme characteristics in platelets, plasma and other human tissues. In Neuropsychopharmacology of Monoamines and Their Regulatory Enzymes (ed. Usdin, E.), pp. 71–85. Raven Press: New York.Google Scholar
Murphy, D. L. & Weiss, R. (1972). Reduced monoamine oxidase activity in blood platelets from bipolar depressed patients. American Journal of Psychiatry 128, 1351–1357.Google Scholar
Murphy, D. L. & Wyatt, R. J. (1972). Reduced monoamine oxidase activity in blood platelets from schizophrenic patients. Nature 238, 225–226.CrossRefGoogle ScholarPubMed
Murphy, D. L. & Wyatt, R. J. (1975). Enzyme studies in the major psychiatric disorders: I. Catechol-O-methyl-transferase, monoamine oxidase in the affective disorders, and factors affecting some behaviour-related enzyme activities. In The Biology of the Major Psychoses: A Comparative Analysis (ed. Freedman, D. X.), pp. 277–288. Raven Press: New York.Google Scholar
Murphy, D. L., Belmaker, R. & Wyatt, R. J. (1974). Monoamine oxidase in schizophrenia and other behavioural disorders. Journal of Psychiatric Research 11, 221–247.Google Scholar
Nies, A., Robinson, D. S., Lamborn, K. R. & Lampert, R. P. (1973). Genetic control of platelet and plasma monoamine oxidase activity. Archives of General Psychiatry 28, 834–838.CrossRefGoogle ScholarPubMed
Nies, A., Robinson, D. S., Harris, L. S. & Lamborn, K. R. (1974). Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives, and controls. In Neuropsychopharmacology of Monoamines and Their Regulatory Enzymes (ed. Usdin, E.), pp. 59–70. Raven Press: New York.Google Scholar
Redmond, D. E. & Murphy, D. L. (1975). Behavioural correlates of platelet monoamine oxidase in rhesus monkeys. Psychosomatic Medicine 37, 80.Google Scholar
Redmond, D. E., Murphy, D. L., Ziegler, M. G., Lake, C. R. & Baulu, J. (1975). Menstrual cycle and ovarian hormone effects on plasma and platelet monoamine oxidase (MAO) and plasma dopamine-beta-hydroxylase (DBH) activities in the rhesus monkey. Psychosomatic Medicine 37, 417–428.Google Scholar
Redmond, D. E., Baulu, J., Murphy, D. L., Loriaux, D. L., Ziegler, M. G. & Lake, C. R. (1976). Effects of testosterone on plasma and platelet monoamine oxidase and plasma dopamine β-hydroxylase activities in the male rhesus monkey. Psychosomatic Medicine 38, 315–326.Google Scholar
Robinson, D. S., Lovenberg, W., Keiser, H. & Sjoerdsma, J. (1968). Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo. Biochemical Pharmacology 17, 109–119.CrossRefGoogle ScholarPubMed
Ross, S. B., Wetterberg, L. & Myrhed, M. (1973). Genetic control of plasma dopamine-β-hydroxylase. Life Science 12, 529–532.CrossRefGoogle ScholarPubMed
Vandenberg, S. G. (1967). Hereditary factors in normal personality traits (as measured by inventories). In Recent Advances in Biological Psychiatry vol. 9 (ed. Wortis, J.), pp. 65–104. Plenum Press: New York.CrossRefGoogle Scholar
Winer, B. J. (1962). Statistical Principles in Experimental Design (chapters 4 and 7). McGraw-Hill: New York.Google Scholar
Wooten, G. F. & Cardon, P. V. (1972). Elevations of plasma DBH activity in man during cold pressor test and exercise. Archives of Neurology 28, 103–106.Google Scholar
Wyatt, R. J. & Murphy, D. L. (1975). Enzyme studies in the major psychiatric disorders. II. Monoamine oxidase in the schizophrenic disorders, dopamine β-hydroxylase, and genetic factors. In The Biology of the Major Psychoses: A Comparative Analysis (ed. Freedman, D. X.), pp. 289–296. Raven Press: New York.Google Scholar
Wyatt, R. J., Murphy, D. L., Belmaker, R., Cohen, S., Donnelly, C. H. & Pollin, W. (1973). Reduced monoamine oxidase activity in platelets: A possible genetic marker for vulnerability to schizophrenia. Science 179, 916–918.CrossRefGoogle ScholarPubMed
Wyatt, R. J., Belmaker, R. & Murphy, D. L. (1975). Low platelet monoamine oxidase and vulnerability to schizophrenia. In Genetics and Psychopharmacology (ed. Mendelewicz, J.), pp. 38–56. Karger: Basel.Google Scholar
Zuckerman, M. (1974). The sensation-seeking motive. In Progress in Experimental Personality Research, vol. 7 (ed. Maher, B.), pp. 79–148. Academic Press: New York.Google Scholar
Zuckerman, M., Bone, R. N., Neary, R., Mangelsdorff, D. & Brustman, B. (1972). What is the sensation seeker? Personality trait and experience correlates of the sensation-seeking scales. Journal of Consulting and Clinical Psychology 39, 308–321.Google Scholar
Zuckerman, M., Murtaugh, T. & Siegel, J. (1974). Sensation seeking and cortical augmenting-reducing. Psychopharmacology 11, 535–542.Google ScholarPubMed