Hostname: page-component-76fb5796d-5g6vh Total loading time: 0 Render date: 2024-04-26T18:47:00.173Z Has data issue: false hasContentIssue false
  • English
  • Français

The association of affective disorder with Huntington's Disease in a case series and in families

Published online by Cambridge University Press:  09 July 2009

Susan E. Folstein ,
Margaret H. Abbott ,
Gary A. Chase ,
Barbara A. Jensen  and
Marshal F. Folstein
Susan E. Folstein*
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Margaret H. Abbott
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gary A. Chase
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Barbara A. Jensen
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Marshal F. Folstein
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
*
1Address for correspondence: Dr Susan E. Foistein, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21205, USA.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Major affective disorder clinically similar to the disorder found in conditions other than Huntington's Disease (HD) was found in 41% of patients with HD in a consecutive case series ascertained through multiple sources in a defined geographical area. The association appears to be confined to certain families, and affective disorder may appear as long as 20 years before the onset of chorea and dementia. The association may represent genetic heterogeneity in HD.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 3 , August 1983 , pp. 537 - 542
Copyright
Copyright © Cambridge University Press 1983

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bickford, J. A. R. & Ellison, R. M. (1953). The high incidence of Huntington's Chorea in the Duchy of Cornwall. Journal of Mental Science 99, 291–294.Google Scholar
Bolt, J. M. (1970). Huntington's Chorea in the west of Scotland. British Journal of Psychiatry 116, 259–270.Google Scholar
Brothers, C. R. D. & Meadows, A. W. (1955). An investigation of Huntington's Chorea in Victoria. Journal of Mental Science 101, 548–563.CrossRefGoogle ScholarPubMed
Bruyn, G. W. (1968). Huntington's Chorea, historical, clinical and laboratory synopsis. In Handbook of Clinical Neurology, vol. 6 (ed. vinken, P. J. and Bruyn, G. W.), pp. 298–378. North-Holland: Amsterdam.Google Scholar
Cooper, J. E., Kendell, R. E., Gurland, B. J., Sharp, L., Copeland, J. R. M. & Simon, R. (1972). Psychiatric Diagnosis in New York and London. Maudsley Monograph No. 20. Oxford University Press: London.Google Scholar
Davenport, C. B. (1916). Huntington's Chorea in relation to heredity and eugenics. American Journal of Insanity 73, 195–222.Google Scholar
Delhanty, J. D. A., Parrington, J. M. & Casey, G. (1981). Growth, DNA repair, sister chromatid exchange and chromosome studies in fibroblasts from Huntington's disease patients. Annals of Human Genetics 45, 181–198.Google Scholar
Dewhurst, K., Oliver, J. E., Trick, K. L. K. & McKnight, A. L. (1969). Neuro-psychiatric aspects of Huntington's Disease. Confinia Neurologia 31, 258–268.Google Scholar
Folstein, M. F., Folstein, S. E. & Chase, G. (1981). Clinical heterogeneity in Huntington's Disease.Paper presented at the First Boston Symposium on Huntington Disease,Boston.November.Google Scholar
Folstein, S. E., Folstein, M. F. & McHugh, P. R. (1979). Psychiatric syndromes in Huntington's Disease. In Advances in Neurology, Vol. 23 (ed. Chase, T. N., Wexler, N. S. and Barbeau, A.), pp. 281–289. Raven Press: New York.Google Scholar
Folstein, S. E., Abbott, M., Moser, R., Parhad, I., Clark, A. & Folstein, M. F. (1981). A phenocopy of Huntington's Disease: lacunar infarcts of the corpus striatum. Johns Hopkins Medical Journal 148, 104–113.Google Scholar
Folstein, S. E., Franz, M. L., Jensen, B., Chase, G. & Foistein, M. F. (1983). Conduct disorder and affective disorder among the offspring of patients with Huntington's Disease. Psychological Medicine 13, 45–52.CrossRefGoogle ScholarPubMed
Goldberg, D. P. (1972). The Detection of Psychiatric Illness by Questionnaire. Maudsley Monograph No. 21. Oxford University Press: London.Google Scholar
Hamilton, A. S. (1908). A report of 27 cases of chronic progressive chorea. American Journal of Insanity 64, 403–475.Google Scholar
Harding, A. E. (1982). The clinical features and classification of the late onset autosomal dominant cerebellar ataxias. Brain 105, 1–28.CrossRefGoogle ScholarPubMed
Hayden, M. R. & Beighton, P. (1982). Genetic aspects of Huntington's Chorea: results of a national survey. American Journal of Medical Genetics 11, 135–141.Google Scholar
Heathfield, K. W. (1967). Huntington's Chorea: investigation into the prevalence of this disease in the area covered by the North East Metropolitan Regional Hospital Board. Brain 90, 203–232.CrossRefGoogle ScholarPubMed
Hughes, E. M. (1924). Social significance of Huntington's Chorea. American Journal of Psychiatry 4, 537–574.Google Scholar
Huntington, G. (1872). On chorea. Medical and Surgical Reporter (Philadelphia) 26, 317.Google Scholar
Klein, D. (1974). Endogenomorphic depression. Archives of General Psychiatry 31, 447–454.Google Scholar
Mattsson, B. (1974). Huntington's Chorea in Sweden. II. Social and clinical data. Acta Psychiatrica Scandinavica Supplement 255, 221–235.CrossRefGoogle Scholar
McHugh, P. R. & Folstein, M. F. (1975). Psychiatric syndromes of Huntington's Chorea: a clinical phenomenologic study. In Psychiatric Aspects of Neurologic Disease (ed. Benson, D. F. and Blumer, D.), pp. 267–286. Grune and Stratton: New York.Google Scholar
Minski, L. & Guttmann, E. (1938). Huntington's Chorea: a study of 34 families. Journal of Mental Science 84, 21–96.CrossRefGoogle Scholar
Oliver, J. E. (1970). Huntington's Chorea in Northamptonshire. British Journal of Psychiatry 116, 241–253.Google Scholar
Paterson, M. C., Bech-Hansen, N. T. & Blattner, W. A. (1982). Survey of human hereditary and familial disorders for gamma ray response in vitro: occurrence of both cellular radio-sensitivity and radio resistance in cancer-prone families. In The Proceedings of 1st Conference of Radio Protectors and AnticarcinogensGaithersburg, Maryland,21 June 1982. Academic Press: New York.Google Scholar
Pyeritz, R. E., Murphy, E. A. & McKusick, V. A. (1979). Clinical variability in the Marfan Syndrome(s). Birth Defects: Orginal Article Series 15, No. 5B. 155–178.Google Scholar
Shokeir, M. H. K. (1975). Investigations on Huntington's Disease in the Canadian Prairies. I. Prevalence. Clinical Genetics 7, 345–348.CrossRefGoogle ScholarPubMed
Thompson, W. D., Orvaschel, H., Prusoff, B. A. & Kidd, K. K. (1983). An evaluation of the family history method for ascertaining psychiatric cases Archives of General Psychiatry (In the press).Google Scholar
Wallace, D. C. (1972). Huntington's Chorea in Queensland: a not uncommon disease. Medical Journal of Australia i, 299–307.Google Scholar
Wallace, D. C. & Hall, A. C. (1972). Evidence of genetic heterogeneity in Huntington's Chorea. Journal of Neurology, Neurosurgery and Psychiatry 35, 789–800.CrossRefGoogle ScholarPubMed
Weissman, M. M. & Myers, J. K. (1978). Affective disorders in a US urban community. Archives of General Psychiatry 35, 1304–1311.Google Scholar