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Reduced activation and altered laterality in two neuroleptic-naive catatonic patients during a motor task in functional MRI

Published online by Cambridge University Press:  01 July 1999

G. NORTHOFF
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
D. F. BRAUS
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
A. SARTORIUS
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
D. KHORAM-SEFAT
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
M. RUSS
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
J. ECKERT
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
M. HERRIG
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
A. LESCHINGER
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
B. BOGERTS
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany
F. A. HENN
Affiliation:
From the Departments of Psychiatry and Radiology, University of Frankfurt; NMR-Research, Central Institute of Mental Health, Mannheim; and Department of Psychiatry, University of Magdeburg, Germany

Abstract

Background. Catatonia, a symptom complex with motor, affective and cognitive symptoms seen in a variety of psychotic conditions and with organic disease, was examined using a motor task using functional magnetic resonance imaging (fMRI).

Methods. Two acute catatonic patients and two age- and sex-matched healthy controls performed sequential finger opposition (SFO) after being medicated with 2 mg of lorazepam (i.v.). Functional magnetic resonance images were collected using a gradient echo pulse sequence (EPI).

Results. Patients with catatonia showed reduced motor activation of the contralateral motor cortex during SFO of the right hand, ipsilateral activation was similar for patients and controls. There were no differences in the activation of the SMA. During left hand activation the right-handed catatonic patients showed more activation in the ipsilateral cortex, a reversal from the normal pattern of activation in which the contralateral side shows four to five times more activation than the ipsilateral side.

Conclusions. In catatonic patients there is a decreased activation in motor cortex during a motor task compared to matched medicated healthy controls. In addition activation of the non-dominant side, left-handed activity in right-handed patients, results in a total reversal of the normal pattern of lateral activation suggesting a disturbance in hemispheric localization of activity during a catatonic state.

Type
BRIEF COMMUNICATION
Copyright
© 1999 Cambridge University Press

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