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Local structural and functional MRI markers of compulsive behaviors and obsessive–compulsive disorder diagnosis within striatum-based circuits

Published online by Cambridge University Press:  29 August 2023

Chuanyong Xu
Affiliation:
Department of Child Psychiatry and Rehabilitation, Institute of Maternity and Child Medical Research, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Gangqiang Hou
Affiliation:
Department of Radiology, Shenzhen Kangning Hospital, Shenzhen, China
Tingxin He
Affiliation:
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, China School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China
Zhongqiang Ruan
Affiliation:
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, China School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China
Xinrong Guo
Affiliation:
Department of Child Psychiatry and Rehabilitation, Institute of Maternity and Child Medical Research, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Jierong Chen
Affiliation:
Department of Child Psychiatry and Rehabilitation, Institute of Maternity and Child Medical Research, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Zhen Wei
Affiliation:
Department of Child Psychiatry and Rehabilitation, Institute of Maternity and Child Medical Research, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Carol A. Seger
Affiliation:
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, China School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China Department of Psychology, Colorado State University, Fort Collins, Colorado, USA
Qi Chen*
Affiliation:
School of Psychology, Shenzhen University, Shenzhen, China
Ziwen Peng*
Affiliation:
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, China School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China
*
Corresponding author: Qi Chen; Email: chenqi@szu.edu.cn or Ziwen Peng; Email: pengzw@m.scnu.edu.cn
Corresponding author: Qi Chen; Email: chenqi@szu.edu.cn or Ziwen Peng; Email: pengzw@m.scnu.edu.cn

Abstract

Background

Obsessive–compulsive disorder (OCD) is a classic disorder on the compulsivity spectrum, with diverse comorbidities. In the current study, we sought to understand OCD from a dimensional perspective by identifying multimodal neuroimaging patterns correlated with multiple phenotypic characteristics within the striatum-based circuits known to be affected by OCD.

Methods

Neuroimaging measurements of local functional and structural features and clinical information were collected from 110 subjects, including 51 patients with OCD and 59 healthy control subjects. Linked independent component analysis (LICA) and correlation analysis were applied to identify associations between local neuroimaging patterns across modalities (including gray matter volume, white matter integrity, and spontaneous functional activity) and clinical factors.

Results

LICA identified eight multimodal neuroimaging patterns related to phenotypic variations, including three related to symptoms and diagnosis. One imaging pattern (IC9) that included both the amplitude of low-frequency fluctuation measure of spontaneous functional activity and white matter integrity measures correlated negatively with OCD diagnosis and diagnostic scales. Two imaging patterns (IC10 and IC27) correlated with compulsion symptoms: IC10 included primarily anatomical measures and IC27 included primarily functional measures. In addition, we identified imaging patterns associated with age, gender, and emotional expression across subjects.

Conclusions

We established that data fusion techniques can identify local multimodal neuroimaging patterns associated with OCD phenotypes. The results inform our understanding of the neurobiological underpinnings of compulsive behaviors and OCD diagnosis.

Type
Original Article
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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Footnotes

*

These authors contributed equally as first authors to this project.

These authors contributed equally as correspondence/senior authors to this project.

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