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Modèles animaux sensibles aux antidépresseurs: implication des systèmes sérotoninergiques et noradrénergiques centraux

Published online by Cambridge University Press:  28 April 2020

P Martin ,
MH Thiébot  and
AJ Puech
P Martin
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
MH Thiébot
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
AJ Puech
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
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Résumé

Tenter de vouloir modéliser chez l’animal une pathologie psychiatrique peut sembler tout à fait illusoire. Il est en revanche plus aisé d’analyser «les grandes fonctions» qui modulent le comportement, ainsi que les systèmes neurobiologiques impliqués dans leur régulation. À travers deux tests comportementaux sensibles aux antidépresseurs: le modèle de «Learned Helplessness» ou «renoncement appris» et le test du labyrinthe en T, mesurant une capacité à attendre; nous avons voulu montrer que les effets de substances antidépressives pouvaient agir sur deux dimensions différentes et de quelle(s) manière(s) pouvaient être impliqués les systèmes sérotoninergiques.

Summary

Summary

Behavioral models of psychiatric disorders do not simulate or reproduce human mental pathology in animals. However, it is possible to evaluate the behavioral and biochemical changes in experimental situations and to propose hypotheses concerning the functions of the CNS. Using 2 tests sensitive to antidepressant drugs: the learned helplessness paradigm and a test for waiting capacity in a T-maze, we investigated the involvement of serotoninergic or noradrenergic processes through 2 dimensions: the reversal of escape deficit and the tolerance to delay of reward.

Keywords

systèmes sérotoninergiquessystèmes noradrénergiquesantidépresseurslearned helplessness paradigmcapacité à attendreimpulsivitéserotoninergic, noradrenergic Systemsantidepressant drugslearned helplessness paradigmwaiting capacityimpulsivity
Type
Article Original
Information
Psychiatry and Psychobiology , Volume 5 , Issue 3 , 1990 , pp. 209 - 217
Copyright
Copyright © European Psychiatric Association

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References

Références

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