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The involvement of oestrogen in the development and function of the normal breast: histological evidence

Published online by Cambridge University Press:  05 December 2011

Thomas J. Anderson  and
Sharon Battersby
Thomas J. Anderson
Affiliation:
Department of Pathology, University of Edinburgh, University Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, U.K.
Sharon Battersby
Affiliation:
Department of Pathology, University of Edinburgh, University Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland, U.K.
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Synopsis

The modifications that occur to breast tissue as a consequence of different physiological states of the female are considered with particular respect to oestrogen. Various tissue responses can be noted and the implications of modulation in cell proliferation, as a consequence of menstrual cycles, pregnancy, oophorectomy and oral contraceptive use, are considered. Assessment of oestrogen receptor by immuno-cytochemistry confirms the involvement of the steroid as a cell stimulant. Evidence from a variety of sources indicates the role in normal breast epithelium is more permissive than deterministic.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 95: Oestrogen and the Human Breast , 1989 , pp. 23 - 32
Copyright
Copyright © Royal Society of Edinburgh 1989

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