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Testing quantitative genetic selection theory with the mouse: A review

Published online by Cambridge University Press:  23 November 2017

E. J. Eisen
E. J. Eisen*
Affiliation:
Animal Science Department, North Carolina State University, Raleigh, NC 27695, USA
*
Email: Gene_Eisen@ncsu.edu
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Extract

The theory of quantitative genetics is used to predict certain outcomes in a dynamic population undergoing selection. The goal of this review is to demonstrate the value of the mouse as a model to test quantitative genetic selection theory.

Heritablity estimates in a base population are used to predict selection response. How good is this prediction? Sheridan (1988) reported discrepancies between predicted and realized heritabilities in selection experiments with laboratory and farm animals. An updated summary of single-trait selection experiments for different traits in mice indicates good agreement between predicted and realized heritabilities (r = 0.81, P < 0.01), with no suggestion of upward or downward bias in the base estimates (Eisen, 2005).

Type
Invited Papers
Information
Proceedings of the British Society of Animal Science , Volume 2005 , 2005 , pp. 238
Copyright
Copyright © The British Society of Animal Science 2005

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References

Bulmer, M. G. 1971. The effect of selection on genetic variability. Am. Nat. 105: 201–211.Google Scholar
Eisen, E. J. 2005. Testing quantitative genetic selection theory. In: The Mouse in Animal Genetics and Breeding Reseach. ed. Eisen, E. J.. Imperial College Press, London (In press).Google Scholar
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Hill, W. G. 1972. Estimation of realized heritabilities for selection experiments. I. Divergent selection. Biometrics 28: 747–765 CrossRefGoogle Scholar
Sheridan, A. K. 1988. Agreement between estimated and realized genetic parameters. Anim. Br. Abst. 56: 877–889.Google Scholar