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Lactation induces hypoleptinaemia and activates orexigenic hypothalamic pathways in sheep

Published online by Cambridge University Press:  20 November 2017

A. Sorensen ,
C.L. Adam ,
P. Findlay ,
M. Marie  and
R.G. Vernon
A. Sorensen
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, UK
C.L. Adam
Affiliation:
Rowett Research Institute, Aberdeen AB21 9SB, UK
P. Findlay
Affiliation:
Rowett Research Institute, Aberdeen AB21 9SB, UK
M. Marie
Affiliation:
Sciences Animales, ENSAIA-INPL, BP 172, 54505, Vandoeuvre les Nancy, France
R.G. Vernon
Affiliation:
Hannah Research Institute, Ayr KA6 5HL, UK
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Extract

The initial period of lactation in domestic ruminants is usually characterised by both hyperphagia and negative energy balance (Barber et al, 1997). The factors regulating the hyperphagia of lactation are not well understood. Leptin is a peptide hormone which is secreted by adipocytes, and which acts on a number of neuropeptides and receptors in the hypothalamus to regulate appetite and energy balance (Spiegelman and Flier, 2001). The aim of this study was to investigate the role of leptin in the hyperphagia of lactation in sheep.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 46
Copyright
Copyright © The British Society of Animal Science 2002

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References

Spiegelman, BM and Flier, JS. 2001. Obesity and the regulation of energy balance. Cell 104: 531–543.CrossRefGoogle ScholarPubMed
Barber, MC, Clegg, RA, Travers, MT, Vernon, RG, 1997. Lipid metabolism in the lactating mammary gland. Biochim Biophys Acta 1347: 101–126.CrossRefGoogle ScholarPubMed