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Autocrine control of milk secretion by a milk protein

Published online by Cambridge University Press:  24 November 2017

C.J. Wilde ,
C.V.P. Addey ,
F.M. Campbell ,
S.A. Connor ,
M.A. Kerr  and
C.H. Knight
C.J. Wilde
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
C.V.P. Addey
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
F.M. Campbell
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
S.A. Connor
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
M.A. Kerr
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
C.H. Knight
Affiliation:
Hannah Research Institute, Ayr KA6 5HL
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Extract

The rate of milk secretion is controlled acutely by the frequency and completeness of milk removal from the mammary gland. Numerous experiments in dairy animals have shown that this acute control is exerted locally within each gland, rather than by circulating galactopoietic hormones (Wilde & Peaker, 1990). Local regulation of milk secretion by milk removal is not related to physical distension of the gland by accumulated milk (Henderson & Peaker, 1984), but is instead the result of changes in the degree of chemical feedback inhibition exerted by a secreted milk constituent.

Proteins that may act as feedback inhibitors of lactation (FIL) have been isolated from goat's milk (Addey et al, 1991a), cow's milk (Addey et al, 1991b) and human milk (Wilde, unpublished work) on the basis of their ability to inhibit synthesis of milk constituents in a rabbit tissue explant bioassay (Wilde et al, 1987a).

Type
The Application of Molecular Biology to Animal Science
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1993: Winter meeting , March 1993 , pp. 159
Copyright
Copyright © The British Society of Animal Production 1993

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References

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