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Seco-limonoid derived from Raputia heptaphylla promotes the control of cutaneous leishmaniasis in hamsters (Mesocricetus auratus)

Published online by Cambridge University Press:  23 December 2015

DIANA GRANADOS-FALLA ,
ANGELA GOMEZ-GALINDO ,
ALEJANDRO DAZA ,
SARA ROBLEDO ,
CARLOS COY-BARRERA ,
LUIS CUCA  and
GABRIELA DELGADO
DIANA GRANADOS-FALLA
Affiliation:
Research Group in Immunotoxicology, Faculty of Sciences, Universidad Nacional de Colombia, Bogota 11001, Colombia
ANGELA GOMEZ-GALINDO
Affiliation:
Research Group in Immunotoxicology, Faculty of Sciences, Universidad Nacional de Colombia, Bogota 11001, Colombia
ALEJANDRO DAZA
Affiliation:
PECET – Medical Research Institute, School of Medicine, Universidad de Antioquia, Medellin 50010, Colombia
SARA ROBLEDO
Affiliation:
PECET – Medical Research Institute, School of Medicine, Universidad de Antioquia, Medellin 50010, Colombia
CARLOS COY-BARRERA
Affiliation:
Research Laboratory of Natural Plant Products, Faculty of Sciences, Universidad Nacional de Colombia, Bogota 11001, Colombia
LUIS CUCA
Affiliation:
Research Laboratory of Natural Plant Products, Faculty of Sciences, Universidad Nacional de Colombia, Bogota 11001, Colombia
GABRIELA DELGADO*
Affiliation:
Research Group in Immunotoxicology, Faculty of Sciences, Universidad Nacional de Colombia, Bogota 11001, Colombia
*
*Corresponding author: Pharmacy Department, Faculty of Sciences, Universidad Nacional de Colombia, Kr 45 # 26–85, Bogota, Colombia. E-mail: lgdelgadom@unal.edu.co.
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Summary

The rational search of novel bioactive molecules against pathogens with immunomodulatory activity is presently one of the most significant approaches to discover and design new therapeutic agents for effective control of infectious diseases, such as the infection caused by Leishmania parasites. In the present study, we evaluated the therapeutic efficacy of the recently characterized immunomodulatory compound 11α,19β-dihydroxy-7-acetoxy-7-deoxoichangin, a seco-limonoid derived from the bark of Raputia heptaphylla (Pittier) using: (1) peritoneal macrophages and (2) Mesocricetus auratus hamsters infected with Leishmania (V.) panamensis and Leishmania (L.) amazonensis. We observed the ability of this seco-limonoid to induce the effective control of the parasite either in vitro [determining an effective concentration 50 (EC50) of 59 µm at the infection model] and in vivo (inducing clinical improvement or even cure in infected animals treated compared with the groups of animals treated with vehicle solution or meglumine antimoniate).

Keywords

Leishmaniatreatmentnatural productsseco-limonoidhamsters
Type
Research Article
Information
Parasitology , Volume 143 , Issue 3 , March 2016 , pp. 289 - 299
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Copyright
Copyright © Cambridge University Press 2015 

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