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Potential role of arteether on N-methyl-D-aspartate (NMDA) receptor expression in experimental cerebral malaria mice and extension of their survival

Published online by Cambridge University Press:  16 July 2019

Sunil Kumar Singh ,
Hemlata Dwivedi ,
Sarika Gunjan ,
Bhavana Singh Chauhan ,
Swaroop Kumar Pandey  and
Renu Tripathi Open the ORCID record for Renu Tripathi [Opens in a new window]
Sunil Kumar Singh
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
Hemlata Dwivedi
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
Sarika Gunjan
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
Bhavana Singh Chauhan
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
Swaroop Kumar Pandey
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
Renu Tripathi*
Affiliation:
Division of Parasitology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India
*
Author for correspondence: Renu Tripathi, E-mail: renu1113@rediffmail.com
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Abstract

Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries. The mechanisms underlying the fatal cerebral complications are still not fully understood. Glutamate, a major excitatory neurotransmitter in the central nervous system of the mammalian brain, plays a key role in the development of neuronal cells, motor function, synaptic plasticity, learning and memory processes under normal physiological conditions. The subtypes of ionotropic glutamate receptor are N-methyl-D-aspartate receptors (NMDARs) which are involved in cellular mechanisms of learning and memory, synaptic plasticity and also mediate excitotoxic neuronal injury. In the present study, we found that glutamate level in synaptosomes, as well as expression of NMDAR, was elevated during the extreme condition of CM in C57BL6 mice. Arteether at 50 mg kg−1 × 1, 25 mg kg−1 × 2, days decreased the NMDAR expression and increased the overall survival of the experimental CM mice.

Keywords

Arteethercerebral malariaglutamateNMDA receptorPlasmodium berghei ANKA
Type
Research Article
Information
Parasitology , Volume 146 , Issue 12 , October 2019 , pp. 1571 - 1577
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Copyright
Copyright © Cambridge University Press 2019 

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