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The potential of vervet monkeys (Cercopithecus aethiops) and baboons (Papio anubis) as models for the study of the immunology of Echinococcus granulosus infections

Published online by Cambridge University Press:  06 April 2009

M. T. Rogan ,
I. Marshall ,
G. D. F. Reid ,
C. N. L. Macpherson  and
P. S. Craig
M. T. Rogan
Affiliation:
Department of Biological Sciences, University of Salford, Salford M5 4WT, UK
I. Marshall
Affiliation:
Division of Biomedical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
G. D. F. Reid
Affiliation:
Institute of Primate Research, Nairobi, Kenya
C. N. L. Macpherson
Affiliation:
Department of Veterinary Parasitology, University of the West Indies, Trinidad
P. S. Craig
Affiliation:
Department of Biological Sciences, University of Salford, Salford M5 4WT, UK
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Summary

Nine vervet monkeys and nine baboons were infected with eggs of Echinococcus granulosus per as. Six of the vervets and one of the baboons possessed hydatid cysts at autopsy, 15–28 months post-infection. The sequential IgG response to hydatid fluid and protoscolex antigens showed considerable inter-animal variation. Infected vervets and baboons became seropositive after an average of 8 months post-infection. Considerable fluctuation in the IgG response was observed, particularly to the hydatid fluid antigen which, in humans, may contribute to the existence of a significant proportion of seronegative individuals. Vervets, in particular, may be useful to study immunological events associated with exposure, development and resolution of hydatid disease in outbred human populations.

Keywords

vervet monkeybaboonEchinococcus granulosusprotoscolex antigenhydatid fluid antigen
Type
Research Article
Information
Parasitology , Volume 106 , Issue 5 , June 1993 , pp. 511 - 517
Copyright
Copyright © Cambridge University Press 1993

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