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Pinning down the role of common luminal intestinal parasitic protists in human health and disease – status and challenges

Published online by Cambridge University Press:  08 February 2019

Christen Rune Stensvold Open the ORCID record for Christen Rune Stensvold [Opens in a new window]
Christen Rune Stensvold*
Affiliation:
Laboratory of Parasitology, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Artillerivej 5, DK–2300 Copenhagen S, Denmark
*
Author for correspondence: Christen Rune Stensvold, E-mail: run@ssi.dk
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Abstract

While some single-celled intestinal parasites are direct causes of diarrhoea and other types of intestinal pathology, the impact of other gut micro-eukaryotes on human health remains elusive. The fact that some common luminal intestinal parasitic protists (CLIPPs) have lately been found more often in healthy than in diseased individuals has fuelled the hypothesis that some parasites might in fact be protective against disease. To this end, the use of new DNA technologies has helped us investigate trans-kingdom relationships in the gut. However, research into these relationships is currently hampered by the limited data available on the genetic diversity within the CLIPPs genera, which results in limited efficacy of publicly available DNA sequence databases for taxonomic annotation of sequences belonging to the eukaryotic component of the gut microbiota. In this paper, I give a brief overview of the status on CLIPPs in human health and disease and challenges related to the mapping of intestinal eukaryotic diversity of the human gut.

Keywords

Intestinal parasitespublic healthdiagnosisDNANGStaxonomyeukaryomemicrobiomemicrobiota
Type
Review Article
Information
Parasitology , Volume 146 , Issue 6 , May 2019 , pp. 695 - 701
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Copyright
Copyright © Cambridge University Press 2019 

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