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Global epidemiology and molecular biology of Taenia multiceps: a comparative meta-analysis and in silico analysis study

Published online by Cambridge University Press:  12 August 2022

Ibrahim Abbas Open the ORCID record for Ibrahim Abbas [Opens in a new window] ,
El-Sayed El-Alfy ,
Somaya Saleh ,
Claudia Tamponi  and
Antonio Varcasia Open the ORCID record for Antonio Varcasia [Opens in a new window]
Ibrahim Abbas*
Affiliation:
Parasitology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
El-Sayed El-Alfy
Affiliation:
Parasitology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
Somaya Saleh
Affiliation:
Parasitology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt
Claudia Tamponi
Affiliation:
Department of Veterinary Medicine, University of Sassari, Sassari, Italy
Antonio Varcasia
Affiliation:
Department of Veterinary Medicine, University of Sassari, Sassari, Italy
*
Author for correspondence: Ibrahim Abbas, E-mail: ielsayed@mans.edu.eg
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Abstract

In the present study, all published data on the epidemiology and molecular characters of Taenia multiceps were systematically collected from relevant databases (e.g. PubMed, Scopus, National Center for Biotechnology Information), and combined in various statistical and genetic analyses as a contribution to a better understanding of the epidemiology of this ubiquitous taeniid worldwide. While 5.8% of the key hosts (dogs) from various countries had T. multiceps, grey wolves displayed the highest prevalence (21.6%) among the definitive hosts. Small ruminants are the main intermediate hosts and carry the coenuri in various locations, but most commonly in the central nervous system (CNS). Cerebral coenuri were confirmed in 53% of sheep exhibiting neurological symptoms, and infected animals often had only a single coenurus in the brain. Sheep had a higher prevalence (8.8%) of CNS coenuri than goats (5.8%); however, extra-CNS coenuri were detected more frequently in goats than in sheep. In either case, the difference between sheep and goats was statistically insignificant. Analysis of 233 partial cytochrome oxidase subunit I nucleotide sections for T. multiceps revealed high haplotype and low nucleotide diversities. Fifty-one haplotypes were detected circulating in 6 geographic populations. China, Iran and Turkey had 2 major haplotypes, whereas Italy and Egypt shared 3. Haplotypes from Greece circulate worldwide, and displayed similar gene flow values when compared with the other populations. There were no distinct patterns for haplotype distribution in relation to the infected hosts or coenuri locations. The existence of genetic variants in T. multiceps was highlighted, but needs further studies.

Keywords

Coenurus cerebralisepidemiologygenetic structuremeta-analysisTaenia multiceps
Type
Research Article
Information
Parasitology , Volume 149 , Issue 12 , October 2022 , pp. 1607 - 1622
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Equal contribution.

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