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Further observations on immunization of sheep against Schistosoma mansoni and S. bovis using irradiation -attenuated schistosomula of homologous and heterologous species

Published online by Cambridge University Press:  06 April 2009

Q. D. Bickle ,
M. G. Taylor ,
E. R. James ,
G. S. Nelson ,
M. F. Hussein ,
B. J. Andrews ,
A. R. Dobinson  and
T. F. de C. Marshall
Q. D. Bickle
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
M. G. Taylor
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
E. R. James
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
G. S. Nelson
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
M. F. Hussein
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
B. J. Andrews
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
A. R. Dobinson
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
T. F. de C. Marshall
Affiliation:
Winches Farm Field Station, London School of Hygiene and Tropical Medicine
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Summary

This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiated schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated S. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection.

Type
Research Article
Information
Parasitology , Volume 78 , Issue 2 , April 1979 , pp. 185 - 193
Copyright
Copyright © Cambridge University Press 1979

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References

REFERENCES

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