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Effect of essential oils on Leishmania amazonensis: a systematic review

Published online by Cambridge University Press:  03 August 2020

Célia Eliane de Lara da Silva ,
Jully Oyama ,
Fabiana Borges Padilha Ferreira Open the ORCID record for Fabiana Borges Padilha Ferreira [Opens in a new window] ,
Marielle Priscila de Paula Lalucci-Silva ,
Tarcísio Vitor Augusto Lordani Open the ORCID record for Tarcísio Vitor Augusto Lordani [Opens in a new window] ,
Rogério Cesar de Lara da Silva Open the ORCID record for Rogério Cesar de Lara da Silva [Opens in a new window] ,
Mariana de Souza Terron Monich ,
Jorge Juarez Vieira Teixeira Open the ORCID record for Jorge Juarez Vieira Teixeira [Opens in a new window]  and
Maria Valdrinez Campana Lonardoni Open the ORCID record for Maria Valdrinez Campana Lonardoni [Opens in a new window]
Célia Eliane de Lara da Silva
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Jully Oyama
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Fabiana Borges Padilha Ferreira
Affiliation:
Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
Marielle Priscila de Paula Lalucci-Silva
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Tarcísio Vitor Augusto Lordani
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Rogério Cesar de Lara da Silva
Affiliation:
Chemical Technology Development Center – CDTEQ, State University of Mato Grosso do Sul, Naviraí, Mato Grosso do Sul, Brazil
Mariana de Souza Terron Monich
Affiliation:
Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
Jorge Juarez Vieira Teixeira
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil
Maria Valdrinez Campana Lonardoni*
Affiliation:
Graduate Program in Bioscience and Physiopathology, Department of Clinical Analysis and Biomedicine, State University of Maringa, Maringá, Paraná, Brazil Graduate Program in Health Sciences, Center of Health Sciences, State University of Maringa, Maringá, Paraná, Brazil
*
Author for correspondence: Maria Valdrinez Campana Lonardoni, E-mail: mvclonardoni@gmail.com
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Abstract

This systematic review investigated the evidence for the therapeutic potential of essential oils (EOs) against Leishmania amazonensis. We searched available scientific publications from 2005 to 2019 in the PubMed and Web of Science electronic databases, according to PRISMA statement. The search strategy utilized descriptors and free terms. The EOs effect of 35 species of plants identified in this systematic review study, 45.7% had half of the maximal inhibitory concentration (IC50) 10 < IC50 ⩽ 50 μg mL−1 and 14.3% had a 10 < IC50μg mL−1 for promastigote forms of L. amazonensis. EOs from Cymbopogon citratus species had the lowest IC50 (1.7 μg mL−1). Among the plant species analyzed for activity against intracellular amastigote forms of L. amazonensis, 39.4% had an IC50 10 < IC50 ⩽ 50 μg mL−1, and 33.3% had an IC50 10 < IC50μg mL−1. Aloysia gratissima EO showed the lowest IC50 (0.16 μg mL−1) for intracellular amastigotes. EOs of Chenopodium ambrosioides, Copaifera martii and Carapa guianensis, administered by the oral route, were effective in reducing parasitic load and lesion volume in L. amazonensis-infected BALB/c mice. EOs of Bixa orellana and C. ambrosioides were effective when administered intraperitoneally. Most of the studies analyzed in vitro and in vivo for the risk of bias showed moderate methodological quality. These results indicate a stimulus for the development of new phytotherapy drugs for leishmaniasis treatment.

Keywords

Essential oilsLeishmania amazonensisphytotherapyplant oils
Type
Review Article
Information
Parasitology , Volume 147 , Issue 13 , November 2020 , pp. 1392 - 1407
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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