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Biochemical perspectives on paralysis and other forms of toxicoses caused by ticks

Published online by Cambridge University Press:  19 April 2005

B. J. MANS
Affiliation:
Department of Biochemistry, University of Pretoria, Pretoria, 0002 South Africa
R. GOTHE
Affiliation:
Department of Biochemistry, University of Pretoria, Pretoria, 0002 South Africa
A. W. H. NEITZ
Affiliation:
Department of Biochemistry, University of Pretoria, Pretoria, 0002 South Africa

Abstract

Tick toxicoses, of which paralysis is the most widespread and dominant form, are important elements of pathogenesis induced by ticks. Tick paralysis is the most widespread and dominant form of tick toxicoses. Non-paralytic forms of tick toxicoses do occur and evidence suggests that these forms of toxicoses are not evolutionary related. While functional significance has been suggested for tick toxins, the advantages for tick survival in general are not clear. This review considers the molecular nature of tick toxins, the possibility that tick toxins have originated more than once independently and whether these toxins could have unrecognized benign functions.

Type
Research Article
Copyright
© 2004 Cambridge University Press

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