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Schistosoma mansoni miracidia: revisiting motility and survival parameters for improved computational modelling

Published online by Cambridge University Press:  16 May 2022

Renata Perotto de Souza*
Affiliation:
Laboratório de Biologia Parasitária, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Vanessa Fey Pascoal
Affiliation:
Laboratório de Biologia Parasitária, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Thomas Nogueira Vilches
Affiliation:
Agent-Based Modelling Laboratory, York University, Toronto, ON, Canada
Hélio Radke Bittencourt
Affiliation:
Escola Politécnica, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Laura Roberta Pinto Utz
Affiliation:
Laboratório de Ecologia Aquática, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
Carlos Graeff-Teixeira
Affiliation:
Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, ES, Brazil
*
Author for correspondence: Renata Perotto de Souza, E-mail: renata.perotto@acad.pucrs.br

Abstract

Schistosoma mansoni is the main causative agent of intestinal schistosomiasis which affects millions of people worldwide. At the larval stage, miracidia are released into bodies of water where they utilize their motility to successfully infect their intermediate host, snails. Here, we revisit the motility and survival of S. mansoni miracidia throughout its life span. Briefly, miracidia motility was monitored at 30-min and 60-min intervals under the presence/absence of natural/artificial light. Based on a subjective evaluation of activity, body shape and transparency, 6 categories of miracidia activity were established from its fully active stage to its immobile larva stage. The estimated life span of miracidia was 5.8 and 3.5 h in the experiments with 60-min and 30-min observation intervals, respectively. Death was defined by an absence of cilia and body movement. When mobility was used as a proxy for infectivity, infective miracidia were detected at 2.5 and 4.5 h, respectively. The present miracidia motility and survival re-evaluation supports parameters optimization for computational modelling of schistosomiasis transmission dynamics. Target control interventions, especially at late stages next to transmission interruption, may greatly benefit from improved modelling studies.

Type
Research Article
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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