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How anthelmintics help us to understand helminths

Published online by Cambridge University Press:  06 April 2009

H. Vanden Bossche
Laboratory of Comparative Biochemistry, Research Laboratories, Janssen Pharmaceutica, B-2340 Beerse, Belgium


Study of the mode of action of the anti-parasitic ‘hydrogenophore’, closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. This uncoupling of mitochondria might be induced by a product(s) excreted by the liver fluke. The lipid extractable product(s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. A second unexpected finding indicates that closantel affects the motility of Schistosoma mansoni in vitro by interferin with mitochondrial ATP synthesis. The results obtained are suggestive of a role for aerobic metabolism in the generation of energy required for motility.

Research Article
Copyright © Cambridge University Press 1985

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